I really sorry what happend meso, i hope you reach homeostasis again in the next weeks or month and reach relief in anhedonia again :c i hope you dont left us.
Mesolimbo wrote:
Sumatriptan (5HT1B/1D full agonist) gave me one of the first "windows" with amelioration of many of the symptoms, but the effect was short-lived as rapid tolerance set in. This shouldn't happen with a partial agonist.
WAY-100135, a research compound, is a 5HT1B/1D partial agonist and 5HT1A antagonist. It looks very interesting, at least on paper.
Given that SERT is downregulated semi-permanently, a partial agonist of 5HT1 receptor (all subtypes) with moderate to high intrinsic activity would be beneficial, I reckon, for limiting serotonin transmission somewhat and offering some symptomatic relief without causing tolerance.
What kinds of relief we can expect whit a 5ht1b/1D agonist?
Mesolimbo wrote:
There's something I've been concerned about. I feel like SJW is upregulating 5HT2A receptors too much, as I'm feeling more anhedonic by the day. I've asked Snake if he does feel the same way and currently waiting for a reply.
This is consistency whit other users had reported on SJW, first, a window, and then, an increase in anhedonia. Sounds logical the theory of 5ht2 upregulatuion and dopamine blunting release.
If 5ht2 blunts dopamine release, that doesnt make it the most stupid receptor in the human brain?
Mesolimbo wrote:
If SJW does so, then I have no choice but to quit it and take Memantine instead for upregulation of 5HT1A and D2-family receptors, as I don't want to take a 5HT2 antagonist to avoid taking too many drugs simultaneously.
Flibanserin downregulated 5ht2 and activates 5ht1a?
Thats doesnt create a perfect synergic whit SJW?
Also, im worried about a possible flibanserin whitdrawal and side effects. Is a new drug. Practically every drug has somekind of tolerance whit time. We know baclofen has it.
Mesolimbo wrote:barbaar wrote:
Hypothetically speaking, what other things would be needed to benefit from LTP? I can't imagine just doing psychedelics by themselves would be enough. I did shrooms a few years ago with no lasting effects, positive or negative.
Restore HPA axis reactivity. Cortisol -> glutamate release -> LTP.
This is why I take Baclofen + Memantine, to downregulate GR (restoring HPA reactivity) and glutamate release (NMDA antagonism mediated).
Meaby you need more glutamate/shrooms in your regimen to make LTP to happend?
Im sorry if this statement sounds like pseudo-cience
----
Also, do flibanserin share a similar mechanism of action of SSRIs?