Knifli intro

[Knifli]

Hi, Yeah i was always very nauseous on the ssri, and still am a lot of the time. I lost a lot of weight because of it too. My my bowel movements are almost back to normal right now, but i had diarrhea the whole time on ssri and some months after. I still experience some stomach and bowel complaints.

[raven100]

Hi, Yeah i was always very nauseous on the ssri, and still am a lot of the time. I lost a lot of weight because of it too. My my bowel movements are almost back to normal right now, but i had diarrhea the whole time on ssri and some months after. I still experience some stomach and bowel complaints.

Check out my post here: http://www.pssdforum.com/viewtopic.php? ... etaine+hcl especially the second link, would be interesting to see if you have the same positive effects I did. I've also found HIIT in the form of sprints and cold showers beneficial.

[Knifli]

Hi, Yeah i was always very nauseous on the ssri, and still am a lot of the time. I lost a lot of weight because of it too. My my bowel movements are almost back to normal right now, but i had diarrhea the whole time on ssri and some months after. I still experience some stomach and bowel complaints.

Check out my post here: http://www.pssdforum.com/viewtopic.php? ... etaine+hcl especially the second link, would be interesting to see if you have the same positive effects I did. I've also found HIIT in the form of sprints and cold showers beneficial.

Thanks, i'm going to look into it.

[Knifli]

1- What is your gender?

Female

2- Why did you take antidepressants in the first place? and for how long were you on them? which med?

5 months, sertraline, depression

3- How was your sexual and emotional function before antidepressant intake?

Never had sexual problems, had some emotional problems, felt melancholic very often and was stressed out, but still could feel positive emotions.

4- What are your symptoms exactly and when did they start? sexual dyfunction alone, or cognitive/emotional/hedonistic as well? which symptom is bothering you the most?

After 1 day i got genital numbness and skinnumbness. But i could still orgasm and be aroused in the first month... although i also had a delayed orgasm once. After a month i lost all my emotions and got in a weird dp/dr state, i didn't care about anything. Also my ability to get aroused went away. My cognition got worse and worse on the drug to a point where i couldn't even read. I also lost the need so socialize with people and my empathy. I also had diarrhea on the drug and was(still am) nauseous a lot. Decreased appitite

My most annoying symptom is my cognition problems (can't think anymore, problems with reading and barely can learn new things) and dp/dr + less emotions.

5- What meds/suppplements have you tried so far?

Sjw : regained some emotions because of it (also libido), but also gave me horrible pelvic floor pain and tailbone pain, decreased genital numbness a tiny bit.

Bethanechol : decreased genital numbness, got me aroused.

Muira puama : made me more empathic, increased skin/genital sensetivity.

6- Do you have access to meds without prescription (buy online), or would strictly require a prescription for meds to try?

My gp is willing to prescripe me some 'safer' meds, if he's not willing to, i can try to get it on the internet.

7- Can you tolerate galicky foods? what about proteins?

Yes

8- Have you done any blood testing? what were the results?

Yes, all hormones in are in range

21/01/2019 (19yo female at this time)
(All ovulatory)
TSH : 2,69 (range 0,51-4,30)
FSH : 12,5 (range : 4,7-21,5)
LH : 34,6 (range : 14,0-95,6)
Oestradiol : 89 (range 48-314)
Progesteron : 1,5 (range 0,1-12,0)
Prolactine : 16,4 (range 4,8-23,3)
Testosteron : 1,85
Testost.bind.globuline : 75,5
Free test : 0,019
DHEA sulfaat : 346,8 (range 65,1-368,0)

[Meso]

OK, it seems that you are suffering mainly from a presynaptic 5HT1A receptor over-expression even before SSRI intake, and after SSRI your postsynaptic 5HT1A became desensitized. This presynaptic 5HT1A over-activation would cause glutamate dysregulation of the pyramidal neurons (cortical, hippocampal, and amygdalar).

After PSSD, you ended up with a sensitive presynaptic autoreceptor and a hyposensitive postsynaptic heteroreceptor. There's also a very significant cholinergic dysfunction.

I would, therefore, recommend this regimen:
- Rivastigmine: 1.5 mg t.i.d. or the patch.
- Baclofen: 25 mg b.i.d.
- Memantine: Start on 5 mg, then titrate up to 10 mg after 2 weeks.
- Flibanserin: 100 mg.

[Knifli]

Thanks a lot for this Meso!

I can't get my hands on Flibanserin, since it's not legal in my country and the customs are pretty strict for orders outside of the EU. Any other suggestions?

Has the presynaptic 5HT1A receptor over-expression before ssri intake anything to do with having pssd symptoms after one pill?

Thanks

(+I've added my bloodwork)

[Meso]

Thanks a lot for this Meso!

I can't get my hands on Flibanserin, since it's not legal in my country and the customs are pretty strict for orders outside of the EU. Any other suggestions?

Has the presynaptic 5HT1A receptor over-expression before ssri intake anything to do with having pssd symptoms after one pill?

Thanks

(+I've added my bloodwork)

Baclofen should be enough if you can get it. Flibanserin would give it a stronger kick, but it's not necessary as Baclofen already inhibits presynaptic 5HT1A indirectly and causes postsyanptic 5HT1A activation.

To make it easier on yourself, try to Baclofen first on its own without Memantine because Memantine could be difficult to get prescribed. It's there for the tolerance, but you can take 2 days off Baclofen each week to prevent tolerance.

[Snake]

Thanks a lot for this Meso!

I can't get my hands on Flibanserin, since it's not legal in my country and the customs are pretty strict for orders outside of the EU. Any other suggestions?

Has the presynaptic 5HT1A receptor over-expression before ssri intake anything to do with having pssd symptoms after one pill?

Thanks

(+I've added my bloodwork)

Baclofen should be enough if you can get it. Flibanserin would give it a stronger kick, but it's not necessary as Baclofen already inhibits presynaptic 5HT1A indirectly and causes postsyanptic 5HT1A activation.

To make it easier on yourself, try to Baclofen first on its own without Memantine because Memantine could be difficult to get prescribed. It's there for the tolerance, but you can take 2 days off Baclofen each week to prevent tolerance.

you mean 7 days on baclofen and then 2 off or 5 days on and 2 off?

[Meso]

you mean 7 days on baclofen and then 2 off or 5 days on and 2 off?

5 days on and 2 days off. 5 days relief per week.

[Knifli]

@Meso I forgot to mention that alcohol hangovers are a lot worse since i have PSSD. During my shroom trip i also got a hangover feeling, and didn't had an emotional trip, only visual. It was really strange. (I took shrooms twice pre-SSRI and both were very emotional trips).