Serotonin
Serotonin
So the idea is to increase serotonin in somewhat safe and controlled manner probably with Rhodiola Rosea (safest), 5-HTP, moclobemide, another maoi, etc. Non-chemical way is cardio. Increased level of serotonin will upregulate SERT via downregulated PKC. 5-HT itself increases SERT. Upregulated SERT will resensitize 5-HT1A. You'll know you're doing it right when those little electric shocks, or brain zaps appear. Brain zaps mean recovery. I'd like to pete (low dose ssri) to chime in.
If I were you I'd load Rhodiola to the point of anxiety and hold it for 3 months at least. Then slowly taper. Slowly and safely.
Personally took LSD, was dying from anxiety for two weeks with dead dick. Mianserin helped greatly because of 2A/2C antagonism (relieve anxiety). After two weeks was kind of obsessive hypersexual. Erection strenght improved.
Foolishly (or not) took one pill of Clomid, which is MAOI most likely, that was two months ago. It was a hell with anxiety, semiautism and depression. Still very little libido, but have best erections from very long time. Brain zaps are quite intense, so I believe 5-HT1A are recovering. Don't recommend it but have very interesting observations.
If I were you I'd load Rhodiola to the point of anxiety and hold it for 3 months at least. Then slowly taper. Slowly and safely.
Personally took LSD, was dying from anxiety for two weeks with dead dick. Mianserin helped greatly because of 2A/2C antagonism (relieve anxiety). After two weeks was kind of obsessive hypersexual. Erection strenght improved.
Foolishly (or not) took one pill of Clomid, which is MAOI most likely, that was two months ago. It was a hell with anxiety, semiautism and depression. Still very little libido, but have best erections from very long time. Brain zaps are quite intense, so I believe 5-HT1A are recovering. Don't recommend it but have very interesting observations.
Last edited by Foxx on Mon Dec 05, 2016 4:56 pm, edited 4 times in total.
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Re: Serotonin - the cure
Is it not premature to be saying it is the cure right now? keep us updated 

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Re: Serotonin
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Last edited by sadKeanu on Wed Aug 22, 2018 11:45 pm, edited 1 time in total.
PSSD Lexapro 2016-Present
Re: Serotonin
Foxx, did you have anxiety, depression, autism-like symptoms as part of your PSSD? Any other serotonin related stuff like dilated pupils?
Re: Serotonin
Original title was: serotonin - the cure.
Definitely premature. But I enjoy that thought very much.
And you know I'm right. This is risky and takes time if you feel you're not ready don't do that. Lowering serotonin when pssded is wrong. Sonny f.ex didn't recover because of abusing Buspar.
Yeah, I am updating. Today had best wood in years.
Definitely premature. But I enjoy that thought very much.
And you know I'm right. This is risky and takes time if you feel you're not ready don't do that. Lowering serotonin when pssded is wrong. Sonny f.ex didn't recover because of abusing Buspar.
Yeah, I am updating. Today had best wood in years.
Re: Serotonin
Hi Foxx,
does it also help with genital numbness?
Thanks,
Recovery
does it also help with genital numbness?
Thanks,
Recovery
Re: Serotonin
Depression: yes
Anxiety: no
Autism: somewhat?
Depersonalization; yes
Cognitive impairment: yes
Pupils: uneven
Premature ejaculation: yes
Delayed ejaculation: no
Anaesthetized penis: not really
Erectile dysfunction: yes
Arousal disorder: yes
Dead libido: yes
Anhedonia: yes
Boosting serotonin WILL screw you dose dependentely for sure. I guess lower the dose longer (and safer) recovery. One drawback is increased 5-HT2A/2C transmission, that means less steroids and hypogonadism caused by serotonin, also decreased appetite and anxiety. So in theory best way would be increase serotonin and antagonize 2A/2C with Mianserin/Mirtazapine. Small dose is needed I guess 5-10mg of Mianserin, or even less, don't have experience with Mirtazapine. Microdosing LSD could be interesting also. Overall quite dangerous, several times I thought I spoiled my brain ultimately, don't mentioning huge load of stress.
Writing about myself though, everyone is different, so take it with a grain of salt.
Although pattern is here. There is no success story (or partial recovery) without serotonin. Also I don't like serotonin phobia here.
Anxiety: no
Autism: somewhat?
Depersonalization; yes
Cognitive impairment: yes
Pupils: uneven
Premature ejaculation: yes
Delayed ejaculation: no
Anaesthetized penis: not really
Erectile dysfunction: yes
Arousal disorder: yes
Dead libido: yes
Anhedonia: yes
Boosting serotonin WILL screw you dose dependentely for sure. I guess lower the dose longer (and safer) recovery. One drawback is increased 5-HT2A/2C transmission, that means less steroids and hypogonadism caused by serotonin, also decreased appetite and anxiety. So in theory best way would be increase serotonin and antagonize 2A/2C with Mianserin/Mirtazapine. Small dose is needed I guess 5-10mg of Mianserin, or even less, don't have experience with Mirtazapine. Microdosing LSD could be interesting also. Overall quite dangerous, several times I thought I spoiled my brain ultimately, don't mentioning huge load of stress.
Writing about myself though, everyone is different, so take it with a grain of salt.
Although pattern is here. There is no success story (or partial recovery) without serotonin. Also I don't like serotonin phobia here.
Re: Serotonin
Thanks for your reply,
treating physical numbness seems to be the hardest part of the cure.
treating physical numbness seems to be the hardest part of the cure.
Re: Serotonin
Science:
http://www.pssdforum.com/viewtopic.php?f=10&t=694
Effects of Chronic Antidepressant Treatments on Serotonin Transporter Function, Density, and mRNA Level
http://www.jneurosci.org/content/19/23/10494.full.pdf
http://www.avensonline.org/fulltextarti ... -0003.html
http://www.pssdforum.com/viewtopic.php?f=10&t=694
Effects of Chronic Antidepressant Treatments on Serotonin Transporter Function, Density, and mRNA Level
http://www.jneurosci.org/content/19/23/10494.full.pdf
MDMA regulates serotonin transporter function via a Protein kinase C dependent mechanismThe mechanism by which SSRIs such as paroxetine and sertraline downregulate the SERT is not currently known. Long-term SSRI administration could induce regulation at the posttranslational level. Using heterologous expression systems, Qian et al. (1997) have shown that stimulation of protein kinase C (PKC) causes internalization of cell-surface SERT protein. SERT phosphorylation via PKC stimulation was shown to occur in tandem with a reduction in 5-HT uptake capacity (Ramamoorthy et al., 1998). Interestingly 5-HT itself reduced the PKC-mediated phosphorylation and internalization of the SERT and SSRIs blocked the effect of 5-HT (Ramamoorthy and Blakely, 1999). Thus, 5-HT may have a direct effect on the SERT to maintain or even increase its density at the plasma membrane and SSRIs could shift the cellular distribution of the SERT. It is not presently known what other kinases can downregulate the SERT by its phosphorylation. It is of interest, though, that the activity of Ca 21/calmodulindependent kinase type II in the hippocampus of rats is increased by chronic administration of SSRIs (Popoli et al., 1995). There is at least one interesting potential clinical implication of these data. There seems to be some proportion of depressed patients who respond beneficially to SSRI treatment but in whom the benefit wanes over time (Byrne and Rothschild, 1998). One wonders if this may be attributable to a drug-induced loss of the SERT, such that the initial cellular target responsible for the beneficial effect of SSRIs is markedly diminished. This phenomenon has not been well-studied with controlled trials (Byrne and Rothschild, 1998). Somewhat more extensively studied, but again not with controlled trials, has been subsequent response of SSRInonresponders (Thase and Rush, 1997; Thase et al., 1997). It does appear that either raising the dose of the SSRI or switching to a different SSRI is successful, in perhaps 40–70% of the patients. Although quite speculative, perhaps SSRI-induced loss of the SERT provides part of the explanation of why some patients do not respond to such strategies.
http://www.avensonline.org/fulltextarti ... -0003.html
Serotonin (5-HT) is a neurotransmitter with an integral role in regulating mood and dysregulation of this system is implicated in disorders such as depression and withdrawal from drugs of abuse. 3,4- methylenedioxymethamphetamine (MDMA) or ‘Ecstasy’ is a commonly abused drug which primarily targets the serotonin transporter (SERT) and competes with serotonin (5-HT) for uptake into the pre-synaptic neuron. By understanding how MDMA regulates SERT function it may be possible to target this system to prevent or reverse the changes seen with MDMA use. Previous studies have shown that MDMA is able to down-regulate SERT expression from the cell surface to intracellular vesicles, thereby decreasing 5-HT transport. How MDMA targets this regulatory pathway is unclear. Protein Kinase C (PKC) is a well-known regulator of SERT, and activation of PKC causes phosphorylation of SERT, targeting the transporter for internalization. In this study, using rotating disc electrode voltammetry (RDEV) we show that MDMA causes a significant decrease in SERT function in HEK-293 cells transiently expressing EGFP-hSERT. This MDMA-induced down-regulation was not observed when cells were pretreated with PKC inhibitor, Bis I. This data shows that the MDMA-induced downregulation of SERT occurs via PKC dependent signaling pathways.
Re: Serotonin
Isn't this the same or nearly the same that jaiho said helped him -SSRI+TCA with 2A/2C antagonism?Foxx wrote:So in theory best way would be increase serotonin and antagonize 2A/2C with Mianserin/Mirtazapine.
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