This is the information I found on Wikipedia
https://en.wikipedia.org/wiki/Cariprazine
Cariprazine inhibits overstimulated dopamine receptors (as antagonists) and stimulates the same receptors when endogenous dopamine levels are low.
Cariprazine[27][14][28]
Site Ki -----(nM)------ IA (%)---- Action
5-HT1A ----- 2.6 ------~??% ------Partial agonist
5-HT2A -----18.8------------------ Antagonist
5-HT2B ----- 0.58------------------ Antagonist
5-HT2C -----134------ ------------Inverse agonist
5-HT7 ------- 111------ ------------Antagonist
α1A ---------155------ ------------Antagonist
D2L ---------0.49------- ~40%------ Partial agonist
D2S --------- 0.69------ ~40%------ Partial agonist
D3 ---------0.085------ ~ 60% ------Partial agonist
H1 ----------23.2--------------------- Antagonist
mACh ----- >1,000 -------------------Antagonist
The smaller the Ki value, the more strongly the drug binds to the site. IA=intrinsic activity.
Has anyone taken Cariprazine? It is mainly used as a partial agonist of D3 and D2 receptors
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Has anyone taken Cariprazine? It is mainly used as a partial agonist of D3 and D2 receptors
2020 Sertraline 3day ---frigidity, lack of pleasure, memory loss and severe genital numbness
2020-2022 dried ginseng ,Trazodone---- Sexual apathy recovers 70%, lack of pleasure recovers 30%, memory loss recovers 20%, genital numbness recovers - 0%
2020-2022 dried ginseng ,Trazodone---- Sexual apathy recovers 70%, lack of pleasure recovers 30%, memory loss recovers 20%, genital numbness recovers - 0%
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Re: Has anyone taken Cariprazine? It is mainly used as a partial agonist of D3 and D2 receptors
Sounds interesting , will you try it ?
Re: Has anyone taken Cariprazine? It is mainly used as a partial agonist of D3 and D2 receptors
may be worth trying for neg schizo symptoms
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