Has anyone taken Cariprazine? It is mainly used as a partial agonist of D3 and D2 receptors

Post any data on Treatments and experimentation.
lolicon16888
Posts: 10
Joined: Sun Dec 11, 2022 12:44 am
Contact:

Has anyone taken Cariprazine? It is mainly used as a partial agonist of D3 and D2 receptors

Unread post by lolicon16888 »

This is the information I found on Wikipedia
https://en.wikipedia.org/wiki/Cariprazine

Cariprazine inhibits overstimulated dopamine receptors (as antagonists) and stimulates the same receptors when endogenous dopamine levels are low.

Cariprazine[27][14][28]
Site Ki -----(nM)------ IA (%)---- Action
5-HT1A ----- 2.6 ------~??% ------Partial agonist
5-HT2A -----18.8------------------ Antagonist
5-HT2B ----- 0.58------------------ Antagonist
5-HT2C -----134------ ------------Inverse agonist
5-HT7 ------- 111------ ------------Antagonist
α1A ---------155------ ------------Antagonist
D2L ---------0.49------- ~40%------ Partial agonist
D2S --------- 0.69------ ~40%------ Partial agonist
D3 ---------0.085------ ~ 60% ------Partial agonist
H1 ----------23.2--------------------- Antagonist
mACh ----- >1,000 -------------------Antagonist
The smaller the Ki value, the more strongly the drug binds to the site. IA=intrinsic activity.
2020 Sertraline 3day ---frigidity, lack of pleasure, memory loss and severe genital numbness
2020-2022 dried ginseng ,Trazodone---- Sexual apathy recovers 70%, lack of pleasure recovers 30%, memory loss recovers 20%, genital numbness recovers - 0%
cdraham
Posts: 448
Joined: Thu Jul 04, 2019 10:39 am
Contact:

Re: Has anyone taken Cariprazine? It is mainly used as a partial agonist of D3 and D2 receptors

Unread post by cdraham »

may be worth trying for neg schizo symptoms
Post Reply

Who is online

Users browsing this forum: No registered users and 7 guests