Someone on Reddit crunched some numbers to show (if I'm reading this correctly) PSSD is caused by SERT inhibition and not interactions with unintended binding-targets.
https://www.reddit.com/r/PSSD/comments/ ... isk_rates/
PSSD risk proportional to potency of SERT inhibition
PSSD risk proportional to potency of SERT inhibition
Archive of PSSD recovery stories: https://pssd.netlify.app/
Re: PSSD risk proportional to potency of SERT inhibition
Makes sense I suppose. It must be some downstream effects from inhibiting SERT that is causing this condition similar to how finasteride inhibits 5ar and this inhibition is causes the downstream upregulating androgenic/neurosteroidal effects that create pfs. I wonder though if what’s happening in pfs is what’s happening with pssd.
Re: PSSD risk proportional to potency of SERT inhibition
"Relative" PSSD risks, from the link:
Also from the link:20% Zoloft
19% Paxil
17% Celexa
22% Lexapro
11% Prozac
I think the calculated risk for Prozac is smaller than expected because of selection bias. It was the first SSRI to be approved in the USA.
If true, this indicates that the true cause of PSSD does in fact lie in the serotonin reuptake inhibition, and does NOT have anything to do with liver enzyme inhibition, or secondary, unintended binding targets, or anything more complicated than "serotonin reuptake inhibition causes PSSD".
Archive of PSSD recovery stories: https://pssd.netlify.app/
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