Post surgery opiods - frustrated as hell

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Gonzo
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Joined: Sun Jan 25, 2015 2:44 pm
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Post surgery opiods - frustrated as hell

Unread post by Gonzo »

I'll be having a couple of surgeries soon and I'm basically worried about the post surgery opioids (and abour the antimietic drugs post general anesthesia as I have bad reaction to general anesthesia)
I've just read that most opioids acts by inhibiting serotonin reuptake.
What should I do? Should I tell doctors about pssd so they can understand which drugs should be avoided? Or are they going to think I'm crazy?
I feel I'm lost, Im so frustrated.
Am I doomed to have another crash?
Gonzo
Posts: 70
Joined: Sun Jan 25, 2015 2:44 pm
Contact:

Re: Post surgery opiods - frustrated as hell

Unread post by Gonzo »

"In vitro studies have investigated the potential mechanisms by which some opioids directly or indirectly increase serotonin levels.6 Dextromethorphan, methadone, pethidine and tramadol inhibit SERT in vitro.7 Fentanyl does not inhibit SERT in vitro but, unlike other opioids, shows affinity for both the 5-HT1A and 5-HT2A receptors.7 As cases of serotonin syndrome have been reported with fentanyl, there may be some SERT-independent effects on the 5-HT system in vivo.7 Codeine, morphine, buprenorphine, oxycodone and dihydrocodeine do not inhibit SERT and do not have affinity for 5-HT receptors.7"

So should I tell them to stick with morphine?
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