Here’s a 2019 review from University of Southern California that summarizes all of the studies into antidepressants and male fertility. The evidence does show that reduce fertility.anacleta wrote: ↑Mon Aug 29, 2022 10:17 amBrain food wrote: ↑Sat Aug 27, 2022 4:37 pm So I have done some more research and have further refined my theory. I think that it's likely that if Kisspeptin causes PSSD, it does so by causing damage to the testicles (in men at least, in women it would be another part of the body). This study from Imperial College London shows that Kisspeptin at high doses causes testicular degeneration in rats. It showed that the rats treated with Kisspeptin experienced damage to their seminiferous tubules. There are several studies in rats that show that SSRIs and Finasteride damage the seminiferous tubules. In review that I mentioned above, the study #92 shows that escitalopram greatly increases kisspeptin levels in certain areas of the brain in rats. This could be causing damage to their testicles and might be the biological mechanism behind PSSD and PFS.
Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697701/
https://bpspubs.onlinelibrary.wiley.com ... 08.00061.x
thanks for the research. i haven't read in detail (i don't have the head to do that right now) but i read about possible "testicular degeneration" so i wonder if it results in reduced male fertility, if so would it be interesting to do a semen analysis? maybe a study comparing sperm quality between men with pssd and without pssd (I think it would also be pretty easy and cheap!)
Effect of antidepressant medications on semen parameters and male fertility
https://onlinelibrary.wiley.com/doi/ful ... /iju.14111
Here’s a 2016 study from Denmark. They also found that SSRIs reduce fertility.
Use of selective serotonin reuptake inhibitors reduces fertility in men
https://onlinelibrary.wiley.com/doi/ful ... #d26151074