True theory of PSSD
Posted: Sun Aug 14, 2022 10:57 am
This information will work for severe form PSSD with anhedonia and emotional blunting but perhaps it can be helpful for mild PSSD with sexual symptoms only.
I already posted it on reddit with some mistakes.
To my opinion, mechanism causing PSSD is fluid accumulation at the extracellular space. SSRI through some mechanism (gut microbiome change is involved too) long-termly alters ability of the body to remove excess fluid from the extracellular space. Free fluid starts to accumulate in extracellular space and Ion concentrations between two fluids starts to correct through the osmosis mechanism and fluid accumulation is happening inside of the nervous (not only) cell. Ions leave the cells. Cell replenish loses from serum electrolytes but overtime serum quantity can reduce too and cells cannot do it so efficiently so cells ions starts to drop too. That is moment when symptoms get worse. Everyone face it after some time. You can find and check your serum potassium blood test 2 years ago and today. And don’t mistake serum and intracellular electrolytes please.
SSRI is already known to induce SIADH inducing removing sodium from blood
There are 3 primary intracellular ions that get tested. Magnesium, potassium, phosphate and protein. They were found elevated in urine in different people with PSSD and propecia forum. It means cells flushes them out constantly. These diseases are very similar. Some ions dominate outside some inside. You can check here.
https://ibb.co/nCv83sC
https://forum.propeciahelp.com/t/full-h ... off/2075/6
https://ibb.co/XYW6j9m
https://forum.propeciahelp.com/t/any-ad ... st/4248/33 - magnesium elevated in urine
https://ibb.co/rG8Xr1d
Erythrocytes ions borderline low. Intracellular ions precisely. Calcium is fine. There are all different people with same pattern. Precisely intracellular electrolytes get excreted or low.
Technically these are different diseases from different drugs but symptoms are very similar.
Unfortunately, people do not share lab tests with me and I do not have laboratory and resources to provide more. However, pattern is too decent to be ignored because at least 4 people shared it.
As you know, cells require ions to function and there are different ions outside and inside of the cell as well as ion gates.
What happens if there is too much fluid in the cell? Resting potential is changed, it’s more difficult to depolarize it, cell can stop working. You cannot cry, laugh, feel. It explains any symptom of severe PSSD.
Some people try random drugs but drug molecule use ions to get inside of the cell when fluid overload exists already. Cell spend ions and cannot replenish at the same capacity because serum concentration can be reduced already because of constant replenishing. And your symptoms get worse. Some people use solutes (inositol) that messes up with particles concentrations what can lead to worsening.
What is partly to blame? Unfortunately, there is too much propaganda about drinking 2-3 liters water daily. It is not necessary and unnatural. It is hypotonic and flushes out electrolytes. Before PSSD body could handle it but after it cannot as mechanism of removing excess is broken and too much fluid gets inside of the cell. When you treat PSSD you should rely only on thirst feeling. It is mechanism of evolution and worked for million years.
There is useless food. For example, wheat only takes something and do not give anything back as well as a sugar. Caffeine. Milk because of calcium. Potatoes are bad too.
Firstly, I recommend dense vegan food. Not too watery. It moves through GI tract very fast and absorbs a lot of fluid and many minerals.
You add electrolytes. Potassium, magnesium, white fish high in protein and phosphate. Not mega doses.
You add diuretic to remove fluid excess. I used acetazolamide.
If you just lay at the bad this may not work. Cells may not absorb anything. You need to do something physical. My experience. You can start with walking
For example you ate, something right took sups and go for a walk or more serious exercise.
You do not drink 3 liters every day. Your body tells you not to. Drink when your body tells you to do so. Some may have psychogenic polydipsia also.
It may be not so simple to do if you are alone. But at least you have some knowledge and hope.
Why cells start lose cells? It needs further investigating. I think it is result of microbiome PH or gas concentration changes.
When fluid concentration outside of cell will drop, the body starts to absorb electrolytes and you will feel better immediately. We keep 120 gram of potassium inside of the cells.
I didn’t mention all things. I will add later.
I already posted it on reddit with some mistakes.
To my opinion, mechanism causing PSSD is fluid accumulation at the extracellular space. SSRI through some mechanism (gut microbiome change is involved too) long-termly alters ability of the body to remove excess fluid from the extracellular space. Free fluid starts to accumulate in extracellular space and Ion concentrations between two fluids starts to correct through the osmosis mechanism and fluid accumulation is happening inside of the nervous (not only) cell. Ions leave the cells. Cell replenish loses from serum electrolytes but overtime serum quantity can reduce too and cells cannot do it so efficiently so cells ions starts to drop too. That is moment when symptoms get worse. Everyone face it after some time. You can find and check your serum potassium blood test 2 years ago and today. And don’t mistake serum and intracellular electrolytes please.
SSRI is already known to induce SIADH inducing removing sodium from blood
There are 3 primary intracellular ions that get tested. Magnesium, potassium, phosphate and protein. They were found elevated in urine in different people with PSSD and propecia forum. It means cells flushes them out constantly. These diseases are very similar. Some ions dominate outside some inside. You can check here.
https://ibb.co/nCv83sC
https://forum.propeciahelp.com/t/full-h ... off/2075/6
https://ibb.co/XYW6j9m
https://forum.propeciahelp.com/t/any-ad ... st/4248/33 - magnesium elevated in urine
https://ibb.co/rG8Xr1d
Erythrocytes ions borderline low. Intracellular ions precisely. Calcium is fine. There are all different people with same pattern. Precisely intracellular electrolytes get excreted or low.
Technically these are different diseases from different drugs but symptoms are very similar.
Unfortunately, people do not share lab tests with me and I do not have laboratory and resources to provide more. However, pattern is too decent to be ignored because at least 4 people shared it.
As you know, cells require ions to function and there are different ions outside and inside of the cell as well as ion gates.
What happens if there is too much fluid in the cell? Resting potential is changed, it’s more difficult to depolarize it, cell can stop working. You cannot cry, laugh, feel. It explains any symptom of severe PSSD.
Some people try random drugs but drug molecule use ions to get inside of the cell when fluid overload exists already. Cell spend ions and cannot replenish at the same capacity because serum concentration can be reduced already because of constant replenishing. And your symptoms get worse. Some people use solutes (inositol) that messes up with particles concentrations what can lead to worsening.
What is partly to blame? Unfortunately, there is too much propaganda about drinking 2-3 liters water daily. It is not necessary and unnatural. It is hypotonic and flushes out electrolytes. Before PSSD body could handle it but after it cannot as mechanism of removing excess is broken and too much fluid gets inside of the cell. When you treat PSSD you should rely only on thirst feeling. It is mechanism of evolution and worked for million years.
There is useless food. For example, wheat only takes something and do not give anything back as well as a sugar. Caffeine. Milk because of calcium. Potatoes are bad too.
Firstly, I recommend dense vegan food. Not too watery. It moves through GI tract very fast and absorbs a lot of fluid and many minerals.
You add electrolytes. Potassium, magnesium, white fish high in protein and phosphate. Not mega doses.
You add diuretic to remove fluid excess. I used acetazolamide.
If you just lay at the bad this may not work. Cells may not absorb anything. You need to do something physical. My experience. You can start with walking
For example you ate, something right took sups and go for a walk or more serious exercise.
You do not drink 3 liters every day. Your body tells you not to. Drink when your body tells you to do so. Some may have psychogenic polydipsia also.
It may be not so simple to do if you are alone. But at least you have some knowledge and hope.
Why cells start lose cells? It needs further investigating. I think it is result of microbiome PH or gas concentration changes.
When fluid concentration outside of cell will drop, the body starts to absorb electrolytes and you will feel better immediately. We keep 120 gram of potassium inside of the cells.
I didn’t mention all things. I will add later.