PSSD: Clinical Experience with a Multimodal Approach (Y. Reisman, T.B. Jannini, E.A. Jannini, 2022)

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anacleta
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PSSD: Clinical Experience with a Multimodal Approach (Y. Reisman, T.B. Jannini, E.A. Jannini, 2022)

Unread post by anacleta »

Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions (PSSD): Clinical Experience with a Multimodal Approach

Yacov Reisman1,*, Tommaso B. Jannini2, Emmanuele A. Jannini3

J. Mens. Health 2022 , 18(8), 165; https://doi.org/10.31083/j.jomh1808165

Submitted: 28 December 2021 | Revised: 24 February 2022 | Accepted: 18 March 2022 | Published: 1 August 2022

Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Abstract

Background: Post-SSRI sexual dysfunction (PSSD) is a set of heterogeneous sexual disorders, that may arise during the administration of antidepressant Selective Serotonin Reuptake Inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitor (SNRIs) and may persist after their discontinuation. PSSD is commonly associated with sexual problems with marked distress and poor quality of life. To date, however, no effective treatment is available. The study describes the clinical experience with a newly introduced systems sexology approach involving bio-psycho-social interventions. Methods: In this study we retrospectively analyzed (from July 2019 to July 2020) twelve PSSD male patients (mean age 31.3 ±± 6.21 years old) treated according to a recently introduced approach involving system sexology and bio-psycho-social interventions. The protocol was based on a combination of lifestyle changes, nutritional supplementation, pharmacological and behavioral interventions. Results: 12 patients with high probability of PSSD were selected. Patients reported a significant improvement in all International Index of Erectile Function-15 (IIEF) domains and Orgasmometer scores from the baseline at 6 months of follow-up. Conclusions: This study described for the first time a feasible and handy treatment procedure for PSSD, framework to improve patients complains, sexual function and satisfaction, and quality of life. Future randomized, placebo-controlled clinical studies with bigger cohorts will be needed in order to better assess this efficacy and confirm our results.



FULL TEXT https://www.imrpress.com/journal/JOMH/1 ... 808165/htm
DeepRacer
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Re: PSSD: Clinical Experience with a Multimodal Approach (Y. Reisman, T.B. Jannini, E.A. Jannini, 2022)

Unread post by DeepRacer »

Nothing but a big cope These researchers and doctors literally have zero creativity and push the same useless health markers and medications with little to no results.
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Re: PSSD: Clinical Experience with a Multimodal Approach (Y. Reisman, T.B. Jannini, E.A. Jannini, 2022)

Unread post by DeepRacer »

Seriously what is the point of testing the same markers over and over where basically all patients have middle of the road levels and treating them with PDE5 inhibitors and serotonin antagonists or dopamine agonists that produce minimal improvement. Anyone who’s been on PSSD/PFS forums for more than five minutes can tell you this is useless. They need to start doing actual deep research into androgen receptors, etc.
arahant
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Re: PSSD: Clinical Experience with a Multimodal Approach (Y. Reisman, T.B. Jannini, E.A. Jannini, 2022)

Unread post by arahant »

Interesting study, down to earth, not getting lost in fancy theories, betting on things that already seem to help. But there's something really impressive:
those participants were able to hold a plethora of interventions, medications, sensate focus training, etc, for fucking 6 months, that's a consistency that I doubt those who claim "tried everything and nothing helped" have ever achieved.
Unfortunately, it is easy to get lost in "root cause" theories instead of doing the protocol proposed by the study.
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
Ritalin + Buspirone (Nov 2019 - today)
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anacleta
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Re: PSSD: Clinical Experience with a Multimodal Approach (Y. Reisman, T.B. Jannini, E.A. Jannini, 2022)

Unread post by anacleta »

Our multimodal treatment, based on life style interventions, L-carnitine/L-arginine integrators, PDE5i and buspirone administration, and behavioral psychotherapies significantly improved every IIEF domain as well as Orgasmometer scores in a cohort of 12 PSSD patients.
Brain food
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Re: PSSD: Clinical Experience with a Multimodal Approach (Y. Reisman, T.B. Jannini, E.A. Jannini, 2022)

Unread post by Brain food »

What are L-carnitine/L-arginine integrators? Has anyone from this forum tried these?
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