Clomipramine and delayed ejaculation: neurophysiological tests
Posted: Mon May 30, 2022 10:46 pm
I found this old article on the mechanism by which clomipramine delays ejaculation:
Effectiveness mechanism of chlomipramine by neurophysiological tests in subjects with true premature ejaculation
https://pubmed.ncbi.nlm.nih.gov/1897755/
Summary. “The effectiveness mechanism of the chlomipramine treatment was evaluated by sacral evoked response (SER) and dorsal nerve somatosensory cortical evoked potential (DN-SEP) testings in 15 patients with true premature ejaculation (TPE). We couldn't demonstrate any significant difference between the values of either latency times or amplitudes of the evoked responses determined just before and at the end of the treatment with chlomipramine in these patients. However, the sensory thresholds were 24.4 ± 4.3 V in the pretreatment term and 30.2 ± 7.3 V at the end of the treatment. This difference is statistically significant (P = 0.0031). Our results suggest that chlomipramine increases the sensory threshold for the stimuli in the genital area.”
Has anyone ever did these kinds of examinations?
Effectiveness mechanism of chlomipramine by neurophysiological tests in subjects with true premature ejaculation
https://pubmed.ncbi.nlm.nih.gov/1897755/
Summary. “The effectiveness mechanism of the chlomipramine treatment was evaluated by sacral evoked response (SER) and dorsal nerve somatosensory cortical evoked potential (DN-SEP) testings in 15 patients with true premature ejaculation (TPE). We couldn't demonstrate any significant difference between the values of either latency times or amplitudes of the evoked responses determined just before and at the end of the treatment with chlomipramine in these patients. However, the sensory thresholds were 24.4 ± 4.3 V in the pretreatment term and 30.2 ± 7.3 V at the end of the treatment. This difference is statistically significant (P = 0.0031). Our results suggest that chlomipramine increases the sensory threshold for the stimuli in the genital area.”
Has anyone ever did these kinds of examinations?
- Sacral evoked response
- Dorsal nerve somatosensory cortical evoked potential