Felt absolutely nothing from Amphetamine
-
- Posts: 103
- Joined: Tue Jun 22, 2021 8:48 am
- Contact:
Felt absolutely nothing from Amphetamine
I took my very first try of amphetamine or speed in 2019 and it was one of the best feelings i've ever felt in my entire life. Fast forward to 2021, in janurary, I was prescribed Lexapro for GAD, and quitted in March, then just today, I was on my second try of amphetamine, and it felt like nothing, a powerful drug like that and literally felt equivalent to caffeine, meth = caffeine, that is just insane. If I had to put a percentage, it seems like the effect of it was reduced by 80% compared to the first try, and it's all thanks to lexapro, even after stopping already. PSSD, anhedonia, it's permanent I feel like, 7 months quit and no improvements.
This SSRI drug, serotonin selective, somehow messed up the dopamine system, no feelings of pleasure, no emotions, nothing.
This SSRI drug, serotonin selective, somehow messed up the dopamine system, no feelings of pleasure, no emotions, nothing.
Re: Felt absolutely nothing from Amphetamine
Maybe the quality of meth you did wasn't that good.
-
- Posts: 14
- Joined: Tue Aug 17, 2021 3:59 am
- Contact:
Re: Felt absolutely nothing from Amphetamine
7months is short. You should wait 2-3 years .
Taking hard drugs probably worsens recovery
Taking hard drugs probably worsens recovery
-
- Posts: 103
- Joined: Tue Jun 22, 2021 8:48 am
- Contact:
-
- Posts: 103
- Joined: Tue Jun 22, 2021 8:48 am
- Contact:
Re: Felt absolutely nothing from Amphetamine
7 months is short? And doctors told me it should leave no lasting side effects and should be symptom free after quitting about a few weeks where they are out of system already lol.Imsostupid wrote: ↑Mon Sep 27, 2021 6:51 pm 7months is short. You should wait 2-3 years .
Taking hard drugs probably worsens recovery
-
- Posts: 168
- Joined: Sun Aug 15, 2021 4:45 pm
Re: Felt absolutely nothing from Amphetamine
Yeah SSRI's do that. They downregulate the effects of Dopamine[/url] through multiple pathways [1] [2] [3]. I didn't notice anything from Amphetamine/Adderall POST-SSRI until I took Remeron with it.ihatelexapro444 wrote: ↑Mon Sep 27, 2021 9:17 pm7 months is short? And doctors told me it should leave no lasting side effects and should be symptom free after quitting about a few weeks where they are out of system already lol.Imsostupid wrote: ↑Mon Sep 27, 2021 6:51 pm 7months is short. You should wait 2-3 years .
Taking hard drugs probably worsens recovery
Dev Neurobiol
. 2007 Jan;67(1):10-22. doi: 10.1002/dneu.20306.
Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors
J Parga 1, J Rodriguez-Pallares, A Muñoz, M J Guerra, J L Labandeira-Garcia
Affiliations expand
PMID: 17443768 DOI: 10.1002/dneu.20306
Abstract
Inductive signals mediating the differentiation of neural precursors into serotonergic (5-HT) or dopaminergic neurons have not been clarified. We have recently shown that in cell aggregates obtained from rat mesencephalic precursors, reduction of serotonin levels induces a marked increase in generation of dopaminergic neurons. In the present study we treated rat neurospheres with antagonists of the main subtypes of 5-HT receptors, 5-HT transport inhibitors, or 5-HT receptor agonists, and studied the effects on generation of dopaminergic neurons. Cultures treated with Methiothepin (5-HT(1,2,5,6,7) receptor antagonist), the 5-HT(4) receptor antagonist GR113808;67:00-.or the 5-HT(7) receptor antagonist SB 269970 showed a significant increase in generation of dopaminergic cells. Treatment with the 5-HT(1B/1D) antagonist GR 127935, the 5-HT(2) antagonist Ritanserin, the 5-HT transporter inhibitor Fluoxetine, the dopamine and norepinephrine transport inhibitor GBR 12935, or with both inhibitors together, or 5-HT(4) or 5-HT(7) receptor agonists induced significant decreases in generation of dopaminergic cells. Cultures treated with WAY100635 (5-HT(1A) receptor antagonist), the 5-HT(3) receptor antagonist Ondasetron, or the 5-HT(6) receptor antagonist SB 258585 did not show any significant changes. Therefore, 5-HT(4) and 5-HT(7) receptors are involved in the observed serotonin-induced decrease in generation of dopaminergic neurons from proliferating neurospheres of mesencephalic precursors. 5-HT(4) and 5-HT(7) receptors were found in astrocytes and serotonergic cells using double immunolabeling and laser confocal microscopy, and the glial receptors appeared to play a major role.
Re: Felt absolutely nothing from Amphetamine
Your serotonin receptors became extremely desensitized from ssri. It's a common symptom of pssd to not be able to get high anymore from drugs.
-
- Posts: 150
- Joined: Tue May 07, 2019 8:30 pm
- Contact:
Re: Felt absolutely nothing from Amphetamine
Area1255_2021 wrote: ↑Mon Sep 27, 2021 9:57 pmYeah SSRI's do that. They downregulate the effects of Dopamine[/url] through multiple pathways [1] [2] [3]. I didn't notice anything from Amphetamine/Adderall POST-SSRI until I took Remeron with it.ihatelexapro444 wrote: ↑Mon Sep 27, 2021 9:17 pm7 months is short? And doctors told me it should leave no lasting side effects and should be symptom free after quitting about a few weeks where they are out of system already lol.Imsostupid wrote: ↑Mon Sep 27, 2021 6:51 pm 7months is short. You should wait 2-3 years .
Taking hard drugs probably worsens recovery
Dev Neurobiol
. 2007 Jan;67(1):10-22. doi: 10.1002/dneu.20306.
Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors
J Parga 1, J Rodriguez-Pallares, A Muñoz, M J Guerra, J L Labandeira-Garcia
Affiliations expand
PMID: 17443768 DOI: 10.1002/dneu.20306
Abstract
Inductive signals mediating the differentiation of neural precursors into serotonergic (5-HT) or dopaminergic neurons have not been clarified. We have recently shown that in cell aggregates obtained from rat mesencephalic precursors, reduction of serotonin levels induces a marked increase in generation of dopaminergic neurons. In the present study we treated rat neurospheres with antagonists of the main subtypes of 5-HT receptors, 5-HT transport inhibitors, or 5-HT receptor agonists, and studied the effects on generation of dopaminergic neurons. Cultures treated with Methiothepin (5-HT(1,2,5,6,7) receptor antagonist), the 5-HT(4) receptor antagonist GR113808;67:00-.or the 5-HT(7) receptor antagonist SB 269970 showed a significant increase in generation of dopaminergic cells. Treatment with the 5-HT(1B/1D) antagonist GR 127935, the 5-HT(2) antagonist Ritanserin, the 5-HT transporter inhibitor Fluoxetine, the dopamine and norepinephrine transport inhibitor GBR 12935, or with both inhibitors together, or 5-HT(4) or 5-HT(7) receptor agonists induced significant decreases in generation of dopaminergic cells. Cultures treated with WAY100635 (5-HT(1A) receptor antagonist), the 5-HT(3) receptor antagonist Ondasetron, or the 5-HT(6) receptor antagonist SB 258585 did not show any significant changes. Therefore, 5-HT(4) and 5-HT(7) receptors are involved in the observed serotonin-induced decrease in generation of dopaminergic neurons from proliferating neurospheres of mesencephalic precursors. 5-HT(4) and 5-HT(7) receptors were found in astrocytes and serotonergic cells using double immunolabeling and laser confocal microscopy, and the glial receptors appeared to play a major role.
On a different note, do you know where to source Metergoline?
My Biohacking YouTube Channel: https://www.youtube.com/c/boostyourbiology/
My Instagram: https://www.instagram.com/ergogenic_health/
My Instagram: https://www.instagram.com/ergogenic_health/
-
- Posts: 168
- Joined: Sun Aug 15, 2021 4:45 pm
Re: Felt absolutely nothing from Amphetamine
IdeaLabs sells it...I've taken it before, but I can't remember for the Life of Me how many drops I took: https://idealabs.ecwid.com/Metergoline-p72862318ErgogenicHealth wrote: ↑Tue Sep 28, 2021 6:08 amArea1255_2021 wrote: ↑Mon Sep 27, 2021 9:57 pmYeah SSRI's do that. They downregulate the effects of Dopamine[/url] through multiple pathways [1] [2] [3]. I didn't notice anything from Amphetamine/Adderall POST-SSRI until I took Remeron with it.ihatelexapro444 wrote: ↑Mon Sep 27, 2021 9:17 pm
7 months is short? And doctors told me it should leave no lasting side effects and should be symptom free after quitting about a few weeks where they are out of system already lol.
Dev Neurobiol
. 2007 Jan;67(1):10-22. doi: 10.1002/dneu.20306.
Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors
J Parga 1, J Rodriguez-Pallares, A Muñoz, M J Guerra, J L Labandeira-Garcia
Affiliations expand
PMID: 17443768 DOI: 10.1002/dneu.20306
Abstract
Inductive signals mediating the differentiation of neural precursors into serotonergic (5-HT) or dopaminergic neurons have not been clarified. We have recently shown that in cell aggregates obtained from rat mesencephalic precursors, reduction of serotonin levels induces a marked increase in generation of dopaminergic neurons. In the present study we treated rat neurospheres with antagonists of the main subtypes of 5-HT receptors, 5-HT transport inhibitors, or 5-HT receptor agonists, and studied the effects on generation of dopaminergic neurons. Cultures treated with Methiothepin (5-HT(1,2,5,6,7) receptor antagonist), the 5-HT(4) receptor antagonist GR113808;67:00-.or the 5-HT(7) receptor antagonist SB 269970 showed a significant increase in generation of dopaminergic cells. Treatment with the 5-HT(1B/1D) antagonist GR 127935, the 5-HT(2) antagonist Ritanserin, the 5-HT transporter inhibitor Fluoxetine, the dopamine and norepinephrine transport inhibitor GBR 12935, or with both inhibitors together, or 5-HT(4) or 5-HT(7) receptor agonists induced significant decreases in generation of dopaminergic cells. Cultures treated with WAY100635 (5-HT(1A) receptor antagonist), the 5-HT(3) receptor antagonist Ondasetron, or the 5-HT(6) receptor antagonist SB 258585 did not show any significant changes. Therefore, 5-HT(4) and 5-HT(7) receptors are involved in the observed serotonin-induced decrease in generation of dopaminergic neurons from proliferating neurospheres of mesencephalic precursors. 5-HT(4) and 5-HT(7) receptors were found in astrocytes and serotonergic cells using double immunolabeling and laser confocal microscopy, and the glial receptors appeared to play a major role.
On a different note, do you know where to source Metergoline?
Who is online
Users browsing this forum: No registered users and 2 guests