Felt absolutely nothing from Amphetamine

[ihatelexapro444]

I took my very first try of amphetamine or speed in 2019 and it was one of the best feelings i've ever felt in my entire life. Fast forward to 2021, in janurary, I was prescribed Lexapro for GAD, and quitted in March, then just today, I was on my second try of amphetamine, and it felt like nothing, a powerful drug like that and literally felt equivalent to caffeine, meth = caffeine, that is just insane. If I had to put a percentage, it seems like the effect of it was reduced by 80% compared to the first try, and it's all thanks to lexapro, even after stopping already. PSSD, anhedonia, it's permanent I feel like, 7 months quit and no improvements.

This SSRI drug, serotonin selective, somehow messed up the dopamine system, no feelings of pleasure, no emotions, nothing.

[GIXXER]

Maybe the quality of meth you did wasn't that good.

[Imsostupid]

7months is short. You should wait 2-3 years .
Taking hard drugs probably worsens recovery

[ihatelexapro444]

Maybe the quality of meth you did wasn't that good.

it's vyvanse, made from doctors and pharma, not street drugs. It's the same exact one I took in 2019.

[ihatelexapro444]

7months is short. You should wait 2-3 years .
Taking hard drugs probably worsens recovery

7 months is short? And doctors told me it should leave no lasting side effects and should be symptom free after quitting about a few weeks where they are out of system already lol.

[Area1255_2021]

7months is short. You should wait 2-3 years .
Taking hard drugs probably worsens recovery

7 months is short? And doctors told me it should leave no lasting side effects and should be symptom free after quitting about a few weeks where they are out of system already lol.

Yeah SSRI's do that. They downregulate the effects of Dopamine[/url] through multiple pathways [1] [2] [3]. I didn't notice anything from Amphetamine/Adderall POST-SSRI until I took Remeron with it.
Dev Neurobiol
. 2007 Jan;67(1):10-22. doi: 10.1002/dneu.20306.
Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors
J Parga 1, J Rodriguez-Pallares, A Muñoz, M J Guerra, J L Labandeira-Garcia
Affiliations expand
PMID: 17443768 DOI: 10.1002/dneu.20306
Abstract
Inductive signals mediating the differentiation of neural precursors into serotonergic (5-HT) or dopaminergic neurons have not been clarified. We have recently shown that in cell aggregates obtained from rat mesencephalic precursors, reduction of serotonin levels induces a marked increase in generation of dopaminergic neurons. In the present study we treated rat neurospheres with antagonists of the main subtypes of 5-HT receptors, 5-HT transport inhibitors, or 5-HT receptor agonists, and studied the effects on generation of dopaminergic neurons. Cultures treated with Methiothepin (5-HT(1,2,5,6,7) receptor antagonist), the 5-HT(4) receptor antagonist GR113808;67:00-.or the 5-HT(7) receptor antagonist SB 269970 showed a significant increase in generation of dopaminergic cells. Treatment with the 5-HT(1B/1D) antagonist GR 127935, the 5-HT(2) antagonist Ritanserin, the 5-HT transporter inhibitor Fluoxetine, the dopamine and norepinephrine transport inhibitor GBR 12935, or with both inhibitors together, or 5-HT(4) or 5-HT(7) receptor agonists induced significant decreases in generation of dopaminergic cells. Cultures treated with WAY100635 (5-HT(1A) receptor antagonist), the 5-HT(3) receptor antagonist Ondasetron, or the 5-HT(6) receptor antagonist SB 258585 did not show any significant changes. Therefore, 5-HT(4) and 5-HT(7) receptors are involved in the observed serotonin-induced decrease in generation of dopaminergic neurons from proliferating neurospheres of mesencephalic precursors. 5-HT(4) and 5-HT(7) receptors were found in astrocytes and serotonergic cells using double immunolabeling and laser confocal microscopy, and the glial receptors appeared to play a major role.

[Tree]

Your serotonin receptors became extremely desensitized from ssri. It's a common symptom of pssd to not be able to get high anymore from drugs.

[cdraham]

Your serotonin receptors became extremely desensitized from ssri. It's a common symptom of pssd to not be able to get high anymore from drugs.

Its nothing to do with serotonin receptors. Pfs /pas people don't react to drugs anymore too

[ErgogenicHealth]

7months is short. You should wait 2-3 years .
Taking hard drugs probably worsens recovery

7 months is short? And doctors told me it should leave no lasting side effects and should be symptom free after quitting about a few weeks where they are out of system already lol.

Yeah SSRI's do that. They downregulate the effects of Dopamine[/url] through multiple pathways [1] [2] [3]. I didn't notice anything from Amphetamine/Adderall POST-SSRI until I took Remeron with it.
Dev Neurobiol
. 2007 Jan;67(1):10-22. doi: 10.1002/dneu.20306.
Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors
J Parga 1, J Rodriguez-Pallares, A Muñoz, M J Guerra, J L Labandeira-Garcia
Affiliations expand
PMID: 17443768 DOI: 10.1002/dneu.20306
Abstract
Inductive signals mediating the differentiation of neural precursors into serotonergic (5-HT) or dopaminergic neurons have not been clarified. We have recently shown that in cell aggregates obtained from rat mesencephalic precursors, reduction of serotonin levels induces a marked increase in generation of dopaminergic neurons. In the present study we treated rat neurospheres with antagonists of the main subtypes of 5-HT receptors, 5-HT transport inhibitors, or 5-HT receptor agonists, and studied the effects on generation of dopaminergic neurons. Cultures treated with Methiothepin (5-HT(1,2,5,6,7) receptor antagonist), the 5-HT(4) receptor antagonist GR113808;67:00-.or the 5-HT(7) receptor antagonist SB 269970 showed a significant increase in generation of dopaminergic cells. Treatment with the 5-HT(1B/1D) antagonist GR 127935, the 5-HT(2) antagonist Ritanserin, the 5-HT transporter inhibitor Fluoxetine, the dopamine and norepinephrine transport inhibitor GBR 12935, or with both inhibitors together, or 5-HT(4) or 5-HT(7) receptor agonists induced significant decreases in generation of dopaminergic cells. Cultures treated with WAY100635 (5-HT(1A) receptor antagonist), the 5-HT(3) receptor antagonist Ondasetron, or the 5-HT(6) receptor antagonist SB 258585 did not show any significant changes. Therefore, 5-HT(4) and 5-HT(7) receptors are involved in the observed serotonin-induced decrease in generation of dopaminergic neurons from proliferating neurospheres of mesencephalic precursors. 5-HT(4) and 5-HT(7) receptors were found in astrocytes and serotonergic cells using double immunolabeling and laser confocal microscopy, and the glial receptors appeared to play a major role.

On a different note, do you know where to source Metergoline?

[Area1255_2021]

7 months is short? And doctors told me it should leave no lasting side effects and should be symptom free after quitting about a few weeks where they are out of system already lol.

Yeah SSRI's do that. They downregulate the effects of Dopamine[/url] through multiple pathways [1] [2] [3]. I didn't notice anything from Amphetamine/Adderall POST-SSRI until I took Remeron with it.
Dev Neurobiol
. 2007 Jan;67(1):10-22. doi: 10.1002/dneu.20306.
Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors
J Parga 1, J Rodriguez-Pallares, A Muñoz, M J Guerra, J L Labandeira-Garcia
Affiliations expand
PMID: 17443768 DOI: 10.1002/dneu.20306
Abstract
Inductive signals mediating the differentiation of neural precursors into serotonergic (5-HT) or dopaminergic neurons have not been clarified. We have recently shown that in cell aggregates obtained from rat mesencephalic precursors, reduction of serotonin levels induces a marked increase in generation of dopaminergic neurons. In the present study we treated rat neurospheres with antagonists of the main subtypes of 5-HT receptors, 5-HT transport inhibitors, or 5-HT receptor agonists, and studied the effects on generation of dopaminergic neurons. Cultures treated with Methiothepin (5-HT(1,2,5,6,7) receptor antagonist), the 5-HT(4) receptor antagonist GR113808;67:00-.or the 5-HT(7) receptor antagonist SB 269970 showed a significant increase in generation of dopaminergic cells. Treatment with the 5-HT(1B/1D) antagonist GR 127935, the 5-HT(2) antagonist Ritanserin, the 5-HT transporter inhibitor Fluoxetine, the dopamine and norepinephrine transport inhibitor GBR 12935, or with both inhibitors together, or 5-HT(4) or 5-HT(7) receptor agonists induced significant decreases in generation of dopaminergic cells. Cultures treated with WAY100635 (5-HT(1A) receptor antagonist), the 5-HT(3) receptor antagonist Ondasetron, or the 5-HT(6) receptor antagonist SB 258585 did not show any significant changes. Therefore, 5-HT(4) and 5-HT(7) receptors are involved in the observed serotonin-induced decrease in generation of dopaminergic neurons from proliferating neurospheres of mesencephalic precursors. 5-HT(4) and 5-HT(7) receptors were found in astrocytes and serotonergic cells using double immunolabeling and laser confocal microscopy, and the glial receptors appeared to play a major role.

On a different note, do you know where to source Metergoline?

IdeaLabs sells it...I've taken it before, but I can't remember for the Life of Me how many drops I took: https://idealabs.ecwid.com/Metergoline-p72862318