NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

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john099
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Re: NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

Unread post by john099 »

Google "DCT for pelvic pain"
Trazohell
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Re: NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

Unread post by Trazohell »

I can confirm, DCT give reliefe but is not a cure, something more complex is fucked up down there. I come more and more to the conclusion it's pudendus nerve damage.
June 2015 - April 2016 Fluoxetine
April 2016 - March 2017 Fluvoxamine
December 2017 9 days Trazodone
After Trazodone PSSD: loss of libido & spontaneous/night/morning erections, prostate/pelvic pain, genital numbness, lower sperm count, Anhedonia
john099
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Re: NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

Unread post by john099 »

I agree Trazohell but i dont think its permanent damage - some do recover fully from PSSD. I think its neuroinflammation being driven by god knows what. Some people get windows and some recover so I dont think its permanent - but if we cant figure it out then i guess it is permanent. Once the Pudential nerve is inflamed it causes pelvic floor dysfunction.
cdraham
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Re: NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

Unread post by cdraham »

john099 wrote: Wed Jul 15, 2020 12:31 pm I agree Trazohell but i dont think its permanent damage - some do recover fully from PSSD. I think its neuroinflammation being driven by god knows what. Some people get windows and some recover so I dont think its permanent - but if we cant figure it out then i guess it is permanent. Once the Pudential nerve is inflamed it causes pelvic floor dysfunction.
I checked my crp level and it was fine. I don't know if it can be neuroinflammation?
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kpavel
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Re: NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

Unread post by kpavel »

I checked pubmed for word 'pudendal' with all ht-receptors. Everything points on articles about voiding control.
https://pubmed.ncbi.nlm.nih.gov/30871873/
https://pubmed.ncbi.nlm.nih.gov/16125683/
https://pubmed.ncbi.nlm.nih.gov/21490366/
Therapeutic new targets for stress urinary incontinence in the central nervous system
https://pubmed.ncbi.nlm.nih.gov/31902839/
Stress urinary incontinence (SUI) is a common and bothersome problem among middle-aged women. However, there are few useful drugs for SUI. Urethral hypermobility and intrinsic sphincter deficiency are two main causes of SUI. Various animal models of SUI, such as vaginal distention, pudendal nerve injury, or ovariectomy, have been developed to study the pathophysiology of SUI. In addition, we have previously reported that cerebral infarction rats also induce SUI. Leak point pressure measurements are the most commonly used methods to evaluate the urethral dysfunction in SUI animal models. Originally, we have developed microtransducer-tipped catheter measurements of urethral activity during sneezing. Previous or our basic research has clarified potential strategies for pharmacotherapy of SUI in the central nervous system. Therapeutic targets include adrenergic and serotonergic (5-HT) receptors in the spinal cord, which stimulate pudendal nerve innervating the external urethral sphincter and/or sympathetic nerve innervating urethral smooth muscle. <b>Activation of α1-adrenoceptors, 5-HT2C, or 5-HT7 receptors enhances the reflex at the spinal cord level whereas pre- or postsynaptic α2-adrenoceptors and/or 5-HT1A receptors inhibit the reflex./<b> We have recently reported that stimulation of the spinal μ-opioid receptors by tramadol also enhances the reflex. Thus, we review the recent advances in basic SUI research and potential targets for pharmacotherapy of SUI in the central nervous system.

Effects of duloxetine and WAY100635 on pudendal inhibition of bladder overactivity in cats
https://pubmed.ncbi.nlm.nih.gov/24667547/
This study was aimed at determining the effect of duloxetine (a serotonin-norepinephrine reuptake inhibitor) on pudendal inhibition of bladder overactivity. Cystometrograms were performed on 15 cats under α-chloralose anesthesia by infusing saline and then 0.25% acetic acid (AA) to induce bladder overactivity. To inhibit bladder overactivity, pudendal nerve stimulation (PNS) at 5 Hz was applied to the right pudendal nerve at two and four times the threshold (T) intensity for inducing anal twitch. Duloxetine (0.03-3 mg/kg) was administered intravenously to determine the effect on PNS inhibition. AA irritation significantly (P < 0.01) reduced bladder capacity to 27.9 ± 4.6% of saline control capacity. PNS alone at both 2T and 4T significantly (P < 0.01) inhibited bladder overactivity and increased bladder capacity to 83.6 ± 7.6% and 87.5 ± 7.7% of saline control, respectively. <b>Duloxetine at low doses (0.03-0.3 mg/kg) caused a significant reduction in PNS inhibition without changing bladder capacity. However, at high doses (1-3 mg/kg) duloxetine significantly increased bladder capacity but still failed to enhance PNS inhibition. WAY100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridyl)cyclohexanecarboxamide; a 5-HT1A receptor antagonist, 0.5-1 mg/kg i.v.) reversed the suppressive effect of duloxetine on PNS inhibition and significantly (P < 0.05) increased the inhibitory effect of duloxetine on bladder overactivity but did not enhance the effect of PNS.</b>These results indicate that activation of 5-HT1A autoreceptors on the serotonergic neurons in the raphe nucleus may suppress duloxetine and PNS inhibition, suggesting that the coadministration of a 5-HT1A antagonist drug might be useful in enhancing the efficacy of duloxetine alone and/or the additive effect of PNS-duloxetine combination for the treatment of overactive bladder symptoms.

https://pubmed.ncbi.nlm.nih.gov/22192599/
https://pubmed.ncbi.nlm.nih.gov/23825079/
So it looks like 5ht1a and 5ht2c receptors have opposite functionality in control of urination, ejaculation and sleep? And could it be that low dose ssri activate ht1a?

Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord.
Lilly Research Laboratories, A division of Eli Lilly and Co., Indianapolis, IN 46285
https://www.ncbi.nlm.nih.gov/pubmed/8350989
Autoradiographic techniques revealed that 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites are differentially distributed in the spinal cords of adult male rats. In the dorsal horn, 5-hydroxytryptamine1A sites were dense in all laminae; 5-hydroxytryptamine1B sites were more dense in laminae I, III and IV than in lamina II; while 5-hydroxytryptamine1C/2 sites were very sparse. The dorsal commissure gray matter also exhibited very dense 5-hydroxytryptamine1A and 5-hydroxytryptamine1B binding. In the intermediate and central gray matter, all three sites were moderately dense at autonomic levels, with exceptionally dense1C/2 binding restricted to the intermediolateral nucleus at rostral thoracic levels. In the ventral horn, 5-hydroxytryptamine1A and 5-hydroxytryptamine1B sites were very sparse (except for very dense 5-hydroxytryptamine1A sites located in the dorsolateral nucleus of the pudendal nerve), while 5-hydroxytryptamine1C/2 sites were relatively dense in motor nuclei. Surprisingly, 5-hydroxytryptamine1B sites were moderately dense in the dorsal column corticospinal tract. These studies will provide an anatomical perspective for interpretation of the complex role of 5-hydroxytryptamine in regulating spinal cord function.
JP1985
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Re: NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

Unread post by JP1985 »

kpavel wrote: Wed Jul 15, 2020 3:33 pm I checked pubmed for word 'pudendal' with all ht-receptors. Everything points on articles about voiding control.
https://pubmed.ncbi.nlm.nih.gov/30871873/
https://pubmed.ncbi.nlm.nih.gov/16125683/
https://pubmed.ncbi.nlm.nih.gov/21490366/
Therapeutic new targets for stress urinary incontinence in the central nervous system
https://pubmed.ncbi.nlm.nih.gov/31902839/
Stress urinary incontinence (SUI) is a common and bothersome problem among middle-aged women. However, there are few useful drugs for SUI. Urethral hypermobility and intrinsic sphincter deficiency are two main causes of SUI. Various animal models of SUI, such as vaginal distention, pudendal nerve injury, or ovariectomy, have been developed to study the pathophysiology of SUI. In addition, we have previously reported that cerebral infarction rats also induce SUI. Leak point pressure measurements are the most commonly used methods to evaluate the urethral dysfunction in SUI animal models. Originally, we have developed microtransducer-tipped catheter measurements of urethral activity during sneezing. Previous or our basic research has clarified potential strategies for pharmacotherapy of SUI in the central nervous system. Therapeutic targets include adrenergic and serotonergic (5-HT) receptors in the spinal cord, which stimulate pudendal nerve innervating the external urethral sphincter and/or sympathetic nerve innervating urethral smooth muscle. <b>Activation of α1-adrenoceptors, 5-HT2C, or 5-HT7 receptors enhances the reflex at the spinal cord level whereas pre- or postsynaptic α2-adrenoceptors and/or 5-HT1A receptors inhibit the reflex./<b> We have recently reported that stimulation of the spinal μ-opioid receptors by tramadol also enhances the reflex. Thus, we review the recent advances in basic SUI research and potential targets for pharmacotherapy of SUI in the central nervous system.

Effects of duloxetine and WAY100635 on pudendal inhibition of bladder overactivity in cats
https://pubmed.ncbi.nlm.nih.gov/24667547/
This study was aimed at determining the effect of duloxetine (a serotonin-norepinephrine reuptake inhibitor) on pudendal inhibition of bladder overactivity. Cystometrograms were performed on 15 cats under α-chloralose anesthesia by infusing saline and then 0.25% acetic acid (AA) to induce bladder overactivity. To inhibit bladder overactivity, pudendal nerve stimulation (PNS) at 5 Hz was applied to the right pudendal nerve at two and four times the threshold (T) intensity for inducing anal twitch. Duloxetine (0.03-3 mg/kg) was administered intravenously to determine the effect on PNS inhibition. AA irritation significantly (P < 0.01) reduced bladder capacity to 27.9 ± 4.6% of saline control capacity. PNS alone at both 2T and 4T significantly (P < 0.01) inhibited bladder overactivity and increased bladder capacity to 83.6 ± 7.6% and 87.5 ± 7.7% of saline control, respectively. <b>Duloxetine at low doses (0.03-0.3 mg/kg) caused a significant reduction in PNS inhibition without changing bladder capacity. However, at high doses (1-3 mg/kg) duloxetine significantly increased bladder capacity but still failed to enhance PNS inhibition. WAY100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridyl)cyclohexanecarboxamide; a 5-HT1A receptor antagonist, 0.5-1 mg/kg i.v.) reversed the suppressive effect of duloxetine on PNS inhibition and significantly (P < 0.05) increased the inhibitory effect of duloxetine on bladder overactivity but did not enhance the effect of PNS.</b>These results indicate that activation of 5-HT1A autoreceptors on the serotonergic neurons in the raphe nucleus may suppress duloxetine and PNS inhibition, suggesting that the coadministration of a 5-HT1A antagonist drug might be useful in enhancing the efficacy of duloxetine alone and/or the additive effect of PNS-duloxetine combination for the treatment of overactive bladder symptoms.

https://pubmed.ncbi.nlm.nih.gov/22192599/
https://pubmed.ncbi.nlm.nih.gov/23825079/
So it looks like 5ht1a and 5ht2c receptors have opposite functionality in control of urination, ejaculation and sleep? And could it be that low dose ssri activate ht1a?

Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord.
Lilly Research Laboratories, A division of Eli Lilly and Co., Indianapolis, IN 46285
https://www.ncbi.nlm.nih.gov/pubmed/8350989
Autoradiographic techniques revealed that 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites are differentially distributed in the spinal cords of adult male rats. In the dorsal horn, 5-hydroxytryptamine1A sites were dense in all laminae; 5-hydroxytryptamine1B sites were more dense in laminae I, III and IV than in lamina II; while 5-hydroxytryptamine1C/2 sites were very sparse. The dorsal commissure gray matter also exhibited very dense 5-hydroxytryptamine1A and 5-hydroxytryptamine1B binding. In the intermediate and central gray matter, all three sites were moderately dense at autonomic levels, with exceptionally dense1C/2 binding restricted to the intermediolateral nucleus at rostral thoracic levels. In the ventral horn, 5-hydroxytryptamine1A and 5-hydroxytryptamine1B sites were very sparse (except for very dense 5-hydroxytryptamine1A sites located in the dorsolateral nucleus of the pudendal nerve), while 5-hydroxytryptamine1C/2 sites were relatively dense in motor nuclei. Surprisingly, 5-hydroxytryptamine1B sites were moderately dense in the dorsal column corticospinal tract. These studies will provide an anatomical perspective for interpretation of the complex role of 5-hydroxytryptamine in regulating spinal cord function.
No idea what this means 😩 If someone could explain that would be great. Does it give us any clues what our problem could be and what to do?
Last pill March 2019 - Citalopram for 7 years
Numbed penis and weak orgasm
Fatigue
Slightly blunted
Dizziness (this has improved a lot in the last 6 months)
JP1985
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Re: NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

Unread post by JP1985 »

john099 wrote: Tue Jul 14, 2020 1:06 pm Many have noticed improvement through relaxing their pelvic floor or doing PT. It may not resolve issues 100% but could help provide some relief until we have a better knowledge of how to improve PSSD. But the problem is the solution for 1 may be different to someone else due to everyone having different genes etc. That is why this is such a hard thing to figure out. At least pelvic floor therapy wont make you worse like some supplements.
I wonder if Botox injections would help? As they relax muscle...
Last pill March 2019 - Citalopram for 7 years
Numbed penis and weak orgasm
Fatigue
Slightly blunted
Dizziness (this has improved a lot in the last 6 months)
JP1985
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Re: NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

Unread post by JP1985 »

I wonder if Botox injections would help? As they relax muscle...


Probably a silly suggestion, just I read that some people use botox who get pelvic floor pain
Last pill March 2019 - Citalopram for 7 years
Numbed penis and weak orgasm
Fatigue
Slightly blunted
Dizziness (this has improved a lot in the last 6 months)
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kpavel
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Re: NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

Unread post by kpavel »

JP1985 wrote: Wed Jul 15, 2020 6:45 pm No idea what this means 😩 If someone could explain that would be great. Does it give us any clues what our problem could be and what to do?
It is research connecting pudendal nerve and serotonin receptors along the pathway to brain, showing specifically how serotonin can cause problems with urinary bladder (mentioned in your starting post).
JP1985
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Re: NUMBNESS - Pudendal EMG nerve conduction test. PLEASE READ

Unread post by JP1985 »

kpavel wrote: Thu Jul 16, 2020 4:05 am
JP1985 wrote: Wed Jul 15, 2020 6:45 pm No idea what this means 😩 If someone could explain that would be great. Does it give us any clues what our problem could be and what to do?
It is research connecting pudendal nerve and serotonin receptors along the pathway to brain, showing specifically how serotonin can cause problems with urinary bladder (mentioned in your starting post).
Yeah I just don’t understand the big words, although it looks like it could be really useful information to some people so thanks for taking the time to put it all together. I wasn’t sure if there was something in there that would give information to what I could do to fix myself and others with the same problem.

I suppose I’m just hoping someone’s going to come up with some magic answer as to what I should do when it’s just not that simple. Ah well, I’ll keep looking for a solution. I’ll go see a pelvic floor specialist and keep people posted on here how everything goes as if I find something that helps it might help the ones with similar symptoms to me!
Last pill March 2019 - Citalopram for 7 years
Numbed penis and weak orgasm
Fatigue
Slightly blunted
Dizziness (this has improved a lot in the last 6 months)
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