R3m3dy info and potentially relevant data
Posted: Thu Nov 15, 2018 8:24 pm
This is the info I need:
1- What is your gender? Male
2- Why did you take antidepressants in the first place? and for how long were you on them? which med? See below
3- How was your sexual and emotional function before antidepressant intake? Excellent
4- What are your symptoms exactly and when did they start? sexual dyfunction alone, or cognitive/emotional/hedonistic as well? which symptom is bothering you the most? See below for explanation of cognitive symptoms. Most of it is pre-pssd but I believe I got some from PSSD as well. Cognitive symptoms are terrible but nothing is worse than the sexual side of PSSD.
5- What meds/suppplements have you tried so far? See below + bethenechol (*may* have slightly helped urination) + PDE5 inhibitors (generally work, require a high dose), psilocybin, every supplement you can imagine under the sun. Only thing I recall having a real effect can be found below.
6- Do you have access to meds without prescription (buy online), or would strictly require a prescription for meds to try? Can buy meds online
7- Can you tolerate galicky foods? what about proteins? I have not noticed distinct signs of intolerance from either
8- Have you done any blood testing? what were the results? At the beginning of my PSSD 8-10 years ago, hormones were through the floor with high prolactin, but improved over time to healthy levels with highish testosterone. Only complaint in recent years is SHBG levels have come back near top of the reference range. With recent intervention they have dropped a little bit. I am planning on taking boron to see if I can bring it down more. Happy to send over all recent blood test results if you wish
Hi everyone. I was a member of the old forum but haven't posted much on this one. I am a 29 year old male living in the United States. When I was 15 I began experiencing severe cognitive impairments (brain fog, short term memory problems, anxiety, difficulty socializing). I went to multiple doctors and specialists pursuing an answer.
At 17 I was told that I had "depression" so I took their word for it and began seeing a psychiatrist and prescribed Sertraline. Google yielded stories of miraculous recovery with these drugs. I told the psychiatrist that it wasn't helping, so every visit he increased my dose (I think I got up to 80mg). Nothing improved, so I was switched to Fluoxetine because according to him it was more "energizing". Again, he continued to increase the dose despite never seeing any benefits. I think I got up to 40mg. Somewhere in there, I developed PSSD. Towards the end I was also put on Adderall XR for "ADHD".
I realized what was happening to me but by then it was too late. I quit (from either 20mg or 10mg fluoxetine, about 2 years into being medicated) and things never normalized. It has been about 10 years now since I've been off all medication. Pretty crazy thinking about it.
I figured out that the cognitive issues that I was told were "depression" were from infrequent cannabis consumption. It flipped something in my brain and I have never been the same since. I do not smoke now and haven't touched it in 7+ years. I came to learn that the same thing happened to a family member. I am convinced there is a genetic component and now know other people who have experienced the same thing. I have had those issues for 12+ years now. Cannabis can be devastating to the developing brain.
Recently a study came out demonstrating a link between these symptoms and modulation of the GABAa receptors https://www.nature.com/articles/s41598-017-11645-8 I know there is some speculation about GABAa in regards to PSSD. If there is a link between the two, I wonder if I made myself more vulnerable to developing PSSD.
Typical PSSD Symptoms are:
-ED
-PE
-No libido
-etc etc.
Cognitive symptoms are (unsure at this point how much of each can be attributed to my initial issue vs PSSD):
-Severe brain fog
-Poor concentration
-Awful short term memory
-Social Cognitive deficits
I have used almost every supplement imaginable. The only thing that I noticed any real effect from was supplementing N-Methyl-D-Aspartic Acid (not normal DAA) after first loading for 2 weeks with high dose Piracetam. (Piracetam has been shown to increase NMDA receptor density). One time after the first dose of N-Methyl-D-Aspartic Acid (dosed at bed time) I experienced two nocturnal emissions in one night. This was a side effect I experienced with some regularity throughout the times I have used N-Methyl-D-Aspartic Acid (used over the course of a couple months on several occasions). N-Methyl-D-Aspartic Acid has an effect on pregnenolone and progesterone levels which are hormones of interest in some theories of PSSD.
I respond to PDE5 inhibitors (thank god), but require a high dose.
1- What is your gender? Male
2- Why did you take antidepressants in the first place? and for how long were you on them? which med? See below
3- How was your sexual and emotional function before antidepressant intake? Excellent
4- What are your symptoms exactly and when did they start? sexual dyfunction alone, or cognitive/emotional/hedonistic as well? which symptom is bothering you the most? See below for explanation of cognitive symptoms. Most of it is pre-pssd but I believe I got some from PSSD as well. Cognitive symptoms are terrible but nothing is worse than the sexual side of PSSD.
5- What meds/suppplements have you tried so far? See below + bethenechol (*may* have slightly helped urination) + PDE5 inhibitors (generally work, require a high dose), psilocybin, every supplement you can imagine under the sun. Only thing I recall having a real effect can be found below.
6- Do you have access to meds without prescription (buy online), or would strictly require a prescription for meds to try? Can buy meds online
7- Can you tolerate galicky foods? what about proteins? I have not noticed distinct signs of intolerance from either
8- Have you done any blood testing? what were the results? At the beginning of my PSSD 8-10 years ago, hormones were through the floor with high prolactin, but improved over time to healthy levels with highish testosterone. Only complaint in recent years is SHBG levels have come back near top of the reference range. With recent intervention they have dropped a little bit. I am planning on taking boron to see if I can bring it down more. Happy to send over all recent blood test results if you wish
Hi everyone. I was a member of the old forum but haven't posted much on this one. I am a 29 year old male living in the United States. When I was 15 I began experiencing severe cognitive impairments (brain fog, short term memory problems, anxiety, difficulty socializing). I went to multiple doctors and specialists pursuing an answer.
At 17 I was told that I had "depression" so I took their word for it and began seeing a psychiatrist and prescribed Sertraline. Google yielded stories of miraculous recovery with these drugs. I told the psychiatrist that it wasn't helping, so every visit he increased my dose (I think I got up to 80mg). Nothing improved, so I was switched to Fluoxetine because according to him it was more "energizing". Again, he continued to increase the dose despite never seeing any benefits. I think I got up to 40mg. Somewhere in there, I developed PSSD. Towards the end I was also put on Adderall XR for "ADHD".
I realized what was happening to me but by then it was too late. I quit (from either 20mg or 10mg fluoxetine, about 2 years into being medicated) and things never normalized. It has been about 10 years now since I've been off all medication. Pretty crazy thinking about it.
I figured out that the cognitive issues that I was told were "depression" were from infrequent cannabis consumption. It flipped something in my brain and I have never been the same since. I do not smoke now and haven't touched it in 7+ years. I came to learn that the same thing happened to a family member. I am convinced there is a genetic component and now know other people who have experienced the same thing. I have had those issues for 12+ years now. Cannabis can be devastating to the developing brain.
Recently a study came out demonstrating a link between these symptoms and modulation of the GABAa receptors https://www.nature.com/articles/s41598-017-11645-8 I know there is some speculation about GABAa in regards to PSSD. If there is a link between the two, I wonder if I made myself more vulnerable to developing PSSD.
Typical PSSD Symptoms are:
-ED
-PE
-No libido
-etc etc.
Cognitive symptoms are (unsure at this point how much of each can be attributed to my initial issue vs PSSD):
-Severe brain fog
-Poor concentration
-Awful short term memory
-Social Cognitive deficits
I have used almost every supplement imaginable. The only thing that I noticed any real effect from was supplementing N-Methyl-D-Aspartic Acid (not normal DAA) after first loading for 2 weeks with high dose Piracetam. (Piracetam has been shown to increase NMDA receptor density). One time after the first dose of N-Methyl-D-Aspartic Acid (dosed at bed time) I experienced two nocturnal emissions in one night. This was a side effect I experienced with some regularity throughout the times I have used N-Methyl-D-Aspartic Acid (used over the course of a couple months on several occasions). N-Methyl-D-Aspartic Acid has an effect on pregnenolone and progesterone levels which are hormones of interest in some theories of PSSD.
I respond to PDE5 inhibitors (thank god), but require a high dose.