R3m3dy info and potentially relevant data

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R3m3dy
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R3m3dy info and potentially relevant data

Unread post by R3m3dy »

This is the info I need:
1- What is your gender? Male
2- Why did you take antidepressants in the first place? and for how long were you on them? which med? See below
3- How was your sexual and emotional function before antidepressant intake? Excellent
4- What are your symptoms exactly and when did they start? sexual dyfunction alone, or cognitive/emotional/hedonistic as well? which symptom is bothering you the most? See below for explanation of cognitive symptoms. Most of it is pre-pssd but I believe I got some from PSSD as well. Cognitive symptoms are terrible but nothing is worse than the sexual side of PSSD.
5- What meds/suppplements have you tried so far? See below + bethenechol (*may* have slightly helped urination) + PDE5 inhibitors (generally work, require a high dose), psilocybin, every supplement you can imagine under the sun. Only thing I recall having a real effect can be found below.
6- Do you have access to meds without prescription (buy online), or would strictly require a prescription for meds to try? Can buy meds online
7- Can you tolerate galicky foods? what about proteins? I have not noticed distinct signs of intolerance from either
8- Have you done any blood testing? what were the results? At the beginning of my PSSD 8-10 years ago, hormones were through the floor with high prolactin, but improved over time to healthy levels with highish testosterone. Only complaint in recent years is SHBG levels have come back near top of the reference range. With recent intervention they have dropped a little bit. I am planning on taking boron to see if I can bring it down more. Happy to send over all recent blood test results if you wish




Hi everyone. I was a member of the old forum but haven't posted much on this one. I am a 29 year old male living in the United States. When I was 15 I began experiencing severe cognitive impairments (brain fog, short term memory problems, anxiety, difficulty socializing). I went to multiple doctors and specialists pursuing an answer.

At 17 I was told that I had "depression" so I took their word for it and began seeing a psychiatrist and prescribed Sertraline. Google yielded stories of miraculous recovery with these drugs. I told the psychiatrist that it wasn't helping, so every visit he increased my dose (I think I got up to 80mg). Nothing improved, so I was switched to Fluoxetine because according to him it was more "energizing". Again, he continued to increase the dose despite never seeing any benefits. I think I got up to 40mg. Somewhere in there, I developed PSSD. Towards the end I was also put on Adderall XR for "ADHD".

I realized what was happening to me but by then it was too late. I quit (from either 20mg or 10mg fluoxetine, about 2 years into being medicated) and things never normalized. It has been about 10 years now since I've been off all medication. Pretty crazy thinking about it.

I figured out that the cognitive issues that I was told were "depression" were from infrequent cannabis consumption. It flipped something in my brain and I have never been the same since. I do not smoke now and haven't touched it in 7+ years. I came to learn that the same thing happened to a family member. I am convinced there is a genetic component and now know other people who have experienced the same thing. I have had those issues for 12+ years now. Cannabis can be devastating to the developing brain.

Recently a study came out demonstrating a link between these symptoms and modulation of the GABAa receptors https://www.nature.com/articles/s41598-017-11645-8 I know there is some speculation about GABAa in regards to PSSD. If there is a link between the two, I wonder if I made myself more vulnerable to developing PSSD.

Typical PSSD Symptoms are:

-ED
-PE
-No libido
-etc etc.

Cognitive symptoms are (unsure at this point how much of each can be attributed to my initial issue vs PSSD):

-Severe brain fog
-Poor concentration
-Awful short term memory
-Social Cognitive deficits



I have used almost every supplement imaginable. The only thing that I noticed any real effect from was supplementing N-Methyl-D-Aspartic Acid (not normal DAA) after first loading for 2 weeks with high dose Piracetam. (Piracetam has been shown to increase NMDA receptor density). One time after the first dose of N-Methyl-D-Aspartic Acid (dosed at bed time) I experienced two nocturnal emissions in one night. This was a side effect I experienced with some regularity throughout the times I have used N-Methyl-D-Aspartic Acid (used over the course of a couple months on several occasions). N-Methyl-D-Aspartic Acid has an effect on pregnenolone and progesterone levels which are hormones of interest in some theories of PSSD.


I respond to PDE5 inhibitors (thank god), but require a high dose.
Last edited by R3m3dy on Fri Apr 26, 2019 11:24 pm, edited 7 times in total.
Charles10
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Re: R3m3dy info and potentially relevant data

Unread post by Charles10 »

me too, i had been taking and stoping isrs since i was 16, but i got pssd when i was 20 yo, right after i smoke weed first time, i smoked for many months, i think it's the cause too, not only the isrs
my history
http://www.pssdforum.com/viewtopic.php?f=14&t=2408
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brman
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Re: R3m3dy info and potentially relevant data

Unread post by brman »

I begun to smoke weed with 12 yo and I still smoke it. I have 36 yo , and before the the SSRI I used cocaine, alcohol, that I still drink in moderation , but sincerelly the damage was cause because I quit the weed ant took th SSRi.
Weed make the this better, believe me. If you read what I posted you will see that I can can do a lot of sex. I have my protocols end etc... But weed do not make you impontent. SSRI is the cause. And BTW I'm doing good, I do not need nothing to do sex, but I know that soon I will need to my protocol with hydergine, l-citrulline and daily cialis just for a few months for other year of good sex!!! BTW, I smoke a lot of Weed, I drink alcohol, I take benzos, I work a lot and fuck off if you believe that weed is the cause.
Other good point about it, I never had sexual problems before the SSRI even using a lot of cocaine, weed, alcohol and etc...
I had a lot of nice girls and girlfriends and I still have a very good sexual life because I used the mainstrean medicine together with I already knew.
Please, do not believe that weed is the cause. SSRI are the problem.

Everybody knows that SSRI are the epigenetic problem.
R3m3dy
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Re: R3m3dy info and potentially relevant data

Unread post by R3m3dy »

Charles10 wrote:me too, i had been taking and stoping isrs since i was 16, but i got pssd when i was 20 yo, right after i smoke weed first time, i smoked for many months, i think it's the cause too, not only the isrs
Interesting. It's really difficult to say what effect it had, if any. Maybe they are linked, maybe I am just the most unlucky person in the world to experience two completely separate rare side effects. I just figured it was worth mentioning taking a look at because if there is a link perhaps it would be helpful in finding a solution.
brman wrote:I begun to smoke weed with 12 yo and I still smoke it. I have 36 yo , and before the the SSRI I used cocaine, alcohol, that I still drink in moderation , but sincerelly the damage was cause because I quit the weed ant took th SSRi.
Weed make the this better, believe me. If you read what I posted you will see that I can can do a lot of sex. I have my protocols end etc... But weed do not make you impontent. SSRI is the cause. And BTW I'm doing good, I do not need nothing to do sex, but I know that soon I will need to my protocol with hydergine, l-citrulline and daily cialis just for a few months for other year of good sex!!! BTW, I smoke a lot of Weed, I drink alcohol, I take benzos, I work a lot and fuck off if you believe that weed is the cause.
Other good point about it, I never had sexual problems before the SSRI even using a lot of cocaine, weed, alcohol and etc...
I had a lot of nice girls and girlfriends and I still have a very good sexual life because I used the mainstrean medicine together with I already knew.
Please, do not believe that weed is the cause. SSRI are the problem.

Everybody knows that SSRI are the epigenetic problem.
You sound like a typical weed zealot that is totally incapable of objective thought. Your opinion is irrelevant and you clearly did not read what I said. Honestly, despite the handful of good people here, people like you are one of the reasons I have never been active here.

I smoked Cananbis and it affected my cognition. It did not give me sexual side effects. However:

Cannabis has a proven effect on GABAa receptors in adolescent brains which leads to cognitive problems. This is a fact.

Some theories regarding PSSD speculate that GABAa has some sort of role in PSSD.

I was simply putting it out there that the effect that Cannabis had on my GABAa receptors **could** have made them more vulnerable to the effect that SSRIs had on my GABAa receptors further down the line when I took SSRIs. It was only after SSRIs that I suffered sexual side effects.
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Meso
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Re: R3m3dy info and potentially relevant data

Unread post by Meso »

The endocannabinoid system mediates long-term depression (LTD) of neural pathways. This is one of my hypothesis regarding how the initially elevated cortisol could trigger permanent PSSD, and how blunting the HPA axis later on can reduce long-term potentiation (LTP). If you are interested in the science, I have a thread about it.

If my hypothesis is correct, then weed + SSRI would induce a very bad PSSD rapidly. That being said, I think you are suffering mainly from a glutamatergic dysfunction.

How long have you been taking NMDA for? How do you react to psychedelics or alcohol hangover?
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R3m3dy
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Re: R3m3dy info and potentially relevant data

Unread post by R3m3dy »

Mesolimbo wrote:The endocannabinoid system mediates long-term depression (LTD) of neural pathways. This is one of my hypothesis regarding how the initially elevated cortisol could trigger permanent PSSD, and how blunting the HPA axis later on can reduce long-term potentiation (LTP). If you are interested in the science, I have a thread about it.

If my hypothesis is correct, then weed + SSRI would induce a very bad PSSD rapidly. That being said, I think you are suffering mainly from a glutamatergic dysfunction.

How long have you been taking NMDA for? How do you react to psychedelics or alcohol hangover?
Thank you so much for taking a look. I have seen a few of your threads and will revisit that one specifically. Would love to understand the science and whether not there is anything that supports the gut feeling I have about the link between my atypical reaction to cannabis and my PSSD.


I have not taken NMDA for years now. I took it for 1x 6 week cycle and 2 two 8 week cycles. Trying to put a timeline together, but I believe the first time I took it was summer 2011, then the beginning of 2013 (with piracetam), then maybe once more in 2014 (with piracetam). I know that some of my friends also experienced very intense dreams from this substance. We had all ordered and taken it as a supplement for the gym, I just happened to experience the NEs (which seems to be something I am predisposed to) which happened mostly during the second cycle I believe.

I have taken acid once (1 hit, then another hit a couple hours after the first hit) a few years ago and psilocybin twice within a couple of weeks this spring. I handled them fine. I experienced some visual effects from the acid but I don't think I experienced much if any really from the mushrooms (not quite high enough of a dose).

In terms of my hangovers, they're generally not the worst unless I drink an exceptional amount of the wrong alcohol and I don't do anything to mediate it.
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Meso
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Re: R3m3dy info and potentially relevant data

Unread post by Meso »

Your symptoms are suggestive of a glutamatergic dysfunction. Although I wouldn't recommend NMDA intake, as it would downregulate the receptors. Try Sarcosine instead, a partial agonist. If you decide on taking Piracetam, make sure to supplement alpha-lipoic acid to minimize hypothalamic inflammation. I prefer Fasoracetam and Coluracetam as more interesting and potent racetams compared to Piracetam. Fasoracetam upregulates GABA-B receptors, which is good for our condition.

Glutamate/LTP dysfunction is at the root of many types of PSSD. It's hard to reverse, so we can only look into potentiating NMDA signalling and maybe low-dose psychedelics if one is willing to take the risks.
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R3m3dy
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Re: R3m3dy info and potentially relevant data

Unread post by R3m3dy »

Mesolimbo wrote:Your symptoms are suggestive of a glutamatergic dysfunction. Although I wouldn't recommend NMDA intake, as it would downregulate the receptors. Try Sarcosine instead, a partial agonist. If you decide on taking Piracetam, make sure to supplement alpha-lipoic acid to minimize hypothalamic inflammation. I prefer Fasoracetam and Coluracetam as more interesting and potent racetams compared to Piracetam. Fasoracetam upregulates GABA-B receptors, which is good for our condition.

Glutamate/LTP dysfunction is at the root of many types of PSSD. It's hard to reverse, so we can only look into potentiating NMDA signalling and maybe low-dose psychedelics if one is willing to take the risks.
Interesting, I've actually had some interest in experimenting with other racetams, particularly those two. I will give them a shot and see what happens.

Thank you for your input
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