Connection to lucid dreaming and PRL-8-53

[DrugsAreBad]

It seems fairly common that people stop dreaming. I searched for chemicals that might promote REM sleep and lucid dreaming and found PRL-8-53. The wiki for this chemical mentions it reverses some effects of Reserpine (which has major sexual side effects). Looks like an interesting connection worth exploring. It looks like a fairly safe chemical as far as I can tell.

If you do try it, please post both weather it worked OR didn't work, as well as dosage and how long you took it.

[nasibi]

Just take Valproate. Steven couldn't dream at all since he got PSSD from Trazodone. Valproate made him dream on the very first or second night.

[been_too_long]

lamotrigine returned my ability to sleep after years without. Some issues with the dreaming but they did return.

[DrugsAreBad]

Speculation about the mechanism of action for PRL-8-53. Looks like it could be relevant. Could also be wrong.

PRL reverses the effects of reserpine, a drug that irreversibly blocks the vesicular monoamine transporter (VMAT). VMAT transports free intracellular monoamine neurotransmitters like dopamine and serotonin into vesicles, which hold and eventually release the neurotransmitters into the synapse. Without VMAT, neurotransmitters are left unprotected in the cytosol and are metabolized by MAO (or COMT), never reaching the synapse. It turns out that HDAC inhibitors can downregulate MAO and COMT to a great degree, while upregulating the monoamine transporters, including dopamine’s and serotonin’s, which pull neurotransmitters back into the cytosol from the synapse after they have been fired into the synapse by vesicles. [1]

Trichostatin A (TSA)

TSA dramatically upregulated the expression of DAT and SLC6A4 (45-fold and 15-fold, respectively), while transcript levels of MAO-A and COMT were significantly reduced (by 70% and by more than 90%, respectively). [2]

[1] https://www.reddit.com/r/Nootropics/com ... of_action/

[2] https://link.springer.com/article/10.10 ... 011-0688-4

[nasibi]

@DrugsAreBad

I also advocate Valproate specifically for its HDAC inhibition property.

[DrugsAreBad]

Apparently low libido is a common side effect of Valproate.