Mianserin

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Whyme11
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Re: Mianserin

Unread post by Whyme11 »

Has anybody pssd get worsen by taking mianserin?
Kinncrimson
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Re: Mianserin

Unread post by Kinncrimson »

Took it for 6 months, no worsening, no improvements
Halan
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Re: Cured by Mianserin 30mg

Unread post by Halan »

Lara J. wrote:Hello!

I am a 27-year-old woman, who was put on Citalopram 4 years ago. I had no benefit of the drug but had almost every possible side effect. However, my doctor insisted on me staying on the drugs and prescribed even more and more. When I talked about quitting (which I often did), she almost yelled at me and told that I am not allowed to quit and also intimidated me about how horrible quitting the drugs is. She said that I shouldn't quit them, no matter what. When I talked about my anhedonia, sexual side effects and being horrible tired (and even about having severe allergic reactions on my face, e.g. urticaria, which I had at last 3 times during the treatment), she just got mad and insisted on me staying on the drugs. I still wonder how I was so stupid and didn't think about myself at the time and did as she said. But, unfortunately, she is my family friend from childhood and maybe that is why I believed her. Also, I think that my general apathy (which was caused by the drugs only) affected me and made me not to think about my own best and made me act against my values (I had always been against all psychiatric drugs).

However. After quitting the drugs, I felt a huge sex drive approximately 1-2 months after quitting. I mean, more than ever. Unfortunately my orgasms were still very premature, though. It took me only a couple of seconds to have them after beginning masturbation. This was very disappointing. But I did not worry about pssd back then.

However, during the following months my sex drive (which had always been huge, even when I had depression) started to go down. Orgasms were still very premature and not so strong as before ssri-medication, and they did not leave me very satisfied. I did not realize it was because of the drugs, however, as I had never heard of pssd. And I did not quite realize that my sex drive was fading all the time.

After 2 years from quitting Citalopram, I finally realized that I had totally lost my sex drive. Before I had attributed it to my difficult life circumstances during those years, but now I realized that it was totally because of pssd. Because it was exactly what it had been from the first day after starting ssri in the first place. All pleasure from sex had gone away, and orgasms were pleasureless and super premature (came only a couple of seconds after beginning masturbation). The orgams were more like reflexes, but had no pleasure in them. On top of that, they felt very weirdly "electric". As I had electricity running in me, but not in a good kind of way. More or less in a sick kind of way. I now attribute that to 5ht-3-receptors which are different from other serotonin receptors and act with electric messaging. These are also the receptors that affect orgasming. So that is why I (and many other people with pssd) can have premature orgasms/ ejaculation even though sexuality is low in general.

During ssri:s, and after quitting them, I had no interest in guys, even though I used to be a person who gets smitten very easily. I still don't realize how I had not realized this back then, but maybe it is because my mood and health were so bad during ssri:s and after. I had to just focus on getting through the day somehow. I had anhedonia and no creativity, and no interest in people, after starting to take ssris and and two years after them. And I had been very creative and very social before (I am an ENFP in Myers Briggs personality chart, if someone has heard of it ;) ).

However, I managed to find a great psychiatrist this spring after realizing I had pssd. He is a professor at one of our most prestigious universities and generally a very nice person, and most importantly, believes in what his clients tell him. So he told me that he has treated 20 clients suffering from pssd during his career (and he lives and practices in a city of 160 000 inhabitants. And he is just ONE psychiatrist. So these cases really do exist, more than many physicians think, and contrary to what pharma industries are willing to admit!!).

But. What I wanted to tell you all here in this forum is this: he said that many of his clients have been cured, and as far as he knew, most of them who are cured are cured 100 %. He said he has prescribed two types of treatments. They are:
- mianserin (varying doses)
- fluoxetine - and then tapering down veeeery slowly, more slowly than physicians usually say - super slowly, and under careful surveillance

Okay. So when I heard of this, I got scared of the fluoxetine option. Even though he said it is his first recommendation. I, however, was too scared of going on ssri:s again. So I wanted to try mianserin. But the idea in the fluoxetine treatment (he told this) is that fluoxetine has a much longer half life than the other ssri:s. And he said that one possible cause for pssd is that some people's physiology needs a much slower and much more gradual tapering of the drugs - fluoxetine is the only drug of ssri:s that allows this, and even with it, he says that people suffering of pssd would have needed a much slower tapering down. He says that this is the way that the genes in the neurons get used to the new situation. Tapering of other ssri:s and, in general, not slow enough tapering is violent to the neurons (they do not know what they are supposed to do anymore).

I, however, tried mianserin. I have experienced healing in some aspects. I started to have sexual dreams at times and "windows" where I would feel sexual desire. Orgasms with pleasure came back and, I think, numbness largely went away. I still don't feel spontaneous desire very much, I mean, if I don't have anything that arouses it (contrary to before when I could suddenly get huge desire, say, in the middle of a school or working day). One of the things that still remain unresolved is that I have premature orgasms. It takes wayyyy too little time to achieve on orgasm. And, because of that, the desire and enjoyment can't grow very big before, because they just don't have the time to build up. Now my biggest wishes are:
- to get that spontaneous desire back
- to get an arousal that builds up and doesn't go away too quickly because of premature arousal & orgasms

Also, I think that before I enjoyed sex more, but that is largely because desire & arousal had more time to build up and grow very big before resolving. I am not super sure if all of the numbness has gone away but much of it is. I am still going to use Mianserin and maybe increase the dose. Now I have been taking it 3 months, of which only 1 month with 30 mg. Before that I had a lower dose, because my psychiatrist wanted it to be that way as I had been so sensitive to the side effects of drugs before. Now I have taken only 20 mg for the past 1,5 weeks, which was my own decision, because of the hunger and tiredness (the only side effects of Mianserin) grew so big, and I also think that my pssd didn't improve going from 20 mg to 30 mg. However, when I visit my doctor I am going to ask if I still could increase the dose (I mean, to 50 mg or so - the biggest one is allowed to prescribe in my country is 90 mg). I was just so tired and hungry (to the point that I almost felt like fainting most of the time) that I decided to make it 20 mg instead of 30 mg. I had some very important exams in Uni (am doing a second degree now) so I couldn't be hungry and tired to the point of fainting.

To cut the long story short: I just wanted to give faith to you guys by telling what my psychiatrist said about possible treatments and cures and, by telling what I myself have experienced with Mianserin. Please don't get mad at me because of me presenting the fluoxetine treatment option - I know that most visitors on these pages curse ssri:s to hell (as I do as well) but this is just what my psychiatrist tells me. And he says that most of his successes with pssd have come with the fluoxetine treatment and then tapering down slowly.

I am going to continue with Mianserin and then, if that doesn't help, try the fluoxetine treatment.

Also, about Mianserin (if some of you are curious):
- my emotions, positivity, emotional balance and creativity have improved with it a lot - at some point I even thought that I can't even be anhedonic or worried when on these drugs
- my sleep is more refreshing and, especially in the beginning of the treatment, I had very vivid and positive, somehow emotionally "healing" dreams

And about the side effects of Mianserin: tiredness during the day is linked with hunger - I am quite hungry when on Mianserin, and when I am, I feel very tired if I don't get food but the tiredness improves when the hunger goes away - so these are not very bad side effects, unless you have some important work / exams to do - so don't be worried about them if you want to try Mianserin :)
Lara, thank you for this report. If possible, keep us updated.
I'd like to know how is the fluoxetine protocol of this psychiatrist. What dose is recommended to start? What's the peak dose and how many months stay on it? How slow he weans off? Probably this varies a little from patient to patient

For months I'm thinking about going back to a SSRI, I just don't know which one would be the best. I'm thinking about Zoloft or Prozac. Unfortunately, the half-life of sertraline is 23h, so maybe taking it 2 times in the day is the best way.
Numby
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Re: Mianserin

Unread post by Numby »

@Halan
I just read that you are interested in fluoxetine. Although your post is from August 7, I would like to say something about fluoxetine. I can absolutely NOT recommend anybody try fluoxetine (except maybe for lowdosing). Fluoxetine gave me very severe PSSD although I tapered off VERY (not to say extremely) slowly. Please do not try fluoxetine. It can cause severe pssd, no matter how slowly you taper off!
iii1i1i1
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Unread post by iii1i1i1 »

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Last edited by iii1i1i1 on Sun Jul 22, 2018 8:51 pm, edited 2 times in total.
iii1i1i1
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Unread post by iii1i1i1 »

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Last edited by iii1i1i1 on Sun Jul 22, 2018 8:50 pm, edited 2 times in total.
sylv
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Re: Mianserin

Unread post by sylv »

From what I have tested ( I suffer from SSRI induced high level emotional blunting + mild SexD ) I found mirtazapine and mianserin deleterious if taken chronically.
The more I took it the more I got blunted. Probably because the constant 5-ht2a blockade is not beneficial to us ( it lowers the activity in prefrontal cortex )

However I've also found that taking 1 dose per week did the trick and i felt better. The anesthesia lowered the day after while blunting got better after the second day. The improvements were small but cumulative. After taking mirtazapine / mianserin I have also made sports, and a lot of emotional rehabilitation along with piracetam and stimulants, mainly amphetamine. I think some overcompensation caused by an acute 5-ht2a blockade is responsible for an improvement in blunting,
Trazohell
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Re: Mianserin

Unread post by Trazohell »

When I read this, I'm seriously considering returning to Fluoxetine.
It cured my mental genital numbness at that time (I had numbness, dissociative disorder in several parts of the body).
But now it's PSSD numbness from Trazodone. Scrotum completely deaf, penis a little less bad but far away from normal. And no libido, with mental numbness my libido was still very high.
So we know that a depression can cause numbness too, so our brains are just disturbed, not destroyed.
What do you think, try to value or too risky?
June 2015 - April 2016 Fluoxetine
April 2016 - March 2017 Fluvoxamine
December 2017 9 days Trazodone
After Trazodone PSSD: loss of libido & spontaneous/night/morning erections, prostate/pelvic pain, genital numbness, lower sperm count, Anhedonia
iii1i1i1
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Unread post by iii1i1i1 »

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Last edited by iii1i1i1 on Sun Jul 22, 2018 8:50 pm, edited 2 times in total.
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JayR
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Re: Mianserin

Unread post by JayR »

iii1i1i1 wrote:I am accelerating the increase of doses after consulting a doctor.
I feel more comfortable about the side effects of mianserin than before when I took it.

today - 20 mg
tomorrow - 30 mg
the day after tomorrow - 40 mg
23.03 - 50 mg
25.03 - 60 mg
27.03 - 70 mg
29.03 - 80 mg
31.03 - 90 mg
Keep us updated bro!
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