PSSD Forum

hs1312 wrote:your SHBG also seems low. Mine was also low like yours. I am not sure if SHBG can play a role in this PSSD?

I doubt it. PSSD occurs at SNC level, so what we see in blood its just a little hint.

Some new literature that people may like:

http://www.kidney-international.org/art ... 5027-8/pdf

And then a little bit of what I wrote about it elsewhere on the internet:
(BTW this is in response to a topic talking about potassium. It can be found in full here: https://www.hackstasis.com/viewtopic.ph ... 5377#p5377)
...


I'm getting more and more interested in the K+ theory because it appears to be tied to Progesterone. Modulating Progesterone has been a long-term goal of mine becuase I think that it's sufficient to cause the downstream SERT density decreases and 5-HT1A autoreceptor desenitization that I still beleive causes a lot of our PSSD symptoms. Note also that Serotonin can do a lot in and out of the brain, and that this could be doing things too. Once you show that something can increase Prog, I can tie it to each and every PSSD (and basically PFS honestly) symptom.


I searched and searched for something that would control Prog, because I think that might be the next layer of the preverbal "onion" in the PSSD puzzle.

Special note here to the studies below that I highlighted, but I will include a few extra just to back up the claims that it all seems to be part of a bigger cascade, which is outlined at: https://pssdlab.wordpress.com/neurohormone-theory/

This is why Estrogen and Testosterone can reverse PSSD in rats. When people on the PSSD forum tried Estrogen, some had total symptom reversal. The problem is the cost, the danger, the hassle, and it doesn't seem to last. This means dig a step deeper. If Estrogen is protecting SERT in the POA, then find out what could mess with that. As expected, Prog can. So if we can tie that a step further backwards into K+ levels, then f*** me we're golden.



Effects of progesterone on the sexual behavior of castrated, testosterone-treated male cynomolgus monkeys (Macaca fascicularis).
https://www.ncbi.nlm.nih.gov/pubmed/9226343

Progesterone decreases mating and estradiol uptake in preoptic areas of male monkeys.
https://www.ncbi.nlm.nih.gov/pubmed/11790421

Enhanced Sexual Behaviors and Androgen Receptor Immunoreactivity in the Male Progesterone Receptor Knockout Mouse
https://academic.oup.com/endo/article-l ... .2005-0490




Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain.
https://www.ncbi.nlm.nih.gov/pubmed/9105666

SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake.
https://www.ncbi.nlm.nih.gov/pubmed/19157982

Serotonin Clearance In Vivo Is Altered to a Greater Extent by Antidepressant-Induced Downregulation of the Serotonin Transporter than by Acute Blockade of this Transporter
http://www.jneurosci.org/content/22/15/6766.full

Evaluation of Endocrine Profile and Hypothalamic-Pituitary-Testis Axis in Selective Serotonin Reuptake Inhibitor-Induced Male Sexual Dysfunction.
http://journals.lww.com/psychopharmacol ... and.9.aspx

Antidepressant-induced internalization of the serotonin transporter in serotonergic neurons
http://www.fasebj.org/content/22/6/1702.full

5-HT1A Receptor Function in Major Depressive Disorder
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736801/

Effects of Chronic Antidepressant Treatments on Serotonin Transporter Function, Density, and mRNA Level
http://www.jneurosci.org/content/19/23/10494.full.pdf

High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People.
http://www.ncbi.nlm.nih.gov/pubmed/25497691

Serotonin transporter SERT mRNA and binding site densities in male rat brain affected by sex steroids. http://www.sciencedirect.com/science/ar ... 8X98002812

...

A question that I do have.

Chicken or the egg? High Prog or Low K+?

Which comes first, and I honestly don't know enough of this literature to say yet... Does K+ decrease Prog receptors? I thought I had read that here? The study above seems to paint a different picture: that lowered K+ increases Prog levels. It doesn't seem to me that decreasing Prog would lower receptor levels, but again maybe I'm missing something and I admittedly have only looked at a handful of papers in this field.

Some new literature that people may like:

http://www.kidney-international.org/art ... 5027-8/pdf

And then a little bit of what I wrote about it elsewhere on the internet:
(BTW this is in response to a topic talking about potassium. It can be found in full here: https://www.hackstasis.com/viewtopic.ph ... 5377#p5377)
...


I'm getting more and more interested in the K+ theory because it appears to be tied to Progesterone. Modulating Progesterone has been a long-term goal of mine becuase I think that it's sufficient to cause the downstream SERT density decreases and 5-HT1A autoreceptor desenitization that I still beleive causes a lot of our PSSD symptoms. Note also that Serotonin can do a lot in and out of the brain, and that this could be doing things too. Once you show that something can increase Prog, I can tie it to each and every PSSD (and basically PFS honestly) symptom.


I searched and searched for something that would control Prog, because I think that might be the next layer of the preverbal "onion" in the PSSD puzzle.

Special note here to the studies below that I highlighted, but I will include a few extra just to back up the claims that it all seems to be part of a bigger cascade, which is outlined at: https://pssdlab.wordpress.com/neurohormone-theory/

This is why Estrogen and Testosterone can reverse PSSD in rats. When people on the PSSD forum tried Estrogen, some had total symptom reversal. The problem is the cost, the danger, the hassle, and it doesn't seem to last. This means dig a step deeper. If Estrogen is protecting SERT in the POA, then find out what could mess with that. As expected, Prog can. So if we can tie that a step further backwards into K+ levels, then f*** me we're golden.



Effects of progesterone on the sexual behavior of castrated, testosterone-treated male cynomolgus monkeys (Macaca fascicularis).
https://www.ncbi.nlm.nih.gov/pubmed/9226343

Progesterone decreases mating and estradiol uptake in preoptic areas of male monkeys.
https://www.ncbi.nlm.nih.gov/pubmed/11790421

Enhanced Sexual Behaviors and Androgen Receptor Immunoreactivity in the Male Progesterone Receptor Knockout Mouse
https://academic.oup.com/endo/article-l ... .2005-0490




Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain.
https://www.ncbi.nlm.nih.gov/pubmed/9105666

SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake.
https://www.ncbi.nlm.nih.gov/pubmed/19157982

Serotonin Clearance In Vivo Is Altered to a Greater Extent by Antidepressant-Induced Downregulation of the Serotonin Transporter than by Acute Blockade of this Transporter
http://www.jneurosci.org/content/22/15/6766.full

Evaluation of Endocrine Profile and Hypothalamic-Pituitary-Testis Axis in Selective Serotonin Reuptake Inhibitor-Induced Male Sexual Dysfunction.
http://journals.lww.com/psychopharmacol ... and.9.aspx

Antidepressant-induced internalization of the serotonin transporter in serotonergic neurons
http://www.fasebj.org/content/22/6/1702.full

5-HT1A Receptor Function in Major Depressive Disorder
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736801/

Effects of Chronic Antidepressant Treatments on Serotonin Transporter Function, Density, and mRNA Level
http://www.jneurosci.org/content/19/23/10494.full.pdf

High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People.
http://www.ncbi.nlm.nih.gov/pubmed/25497691

Serotonin transporter SERT mRNA and binding site densities in male rat brain affected by sex steroids. http://www.sciencedirect.com/science/ar ... 8X98002812

...

A question that I do have.

Chicken or the egg? High Prog or Low K+?

Which comes first, and I honestly don't know enough of this literature to say yet... Does K+ decrease Prog receptors? I thought I had read that here? The study above seems to paint a different picture: that lowered K+ increases Prog levels. It doesn't seem to me that decreasing Prog would lower receptor levels, but again maybe I'm missing something and I admittedly have only looked at a handful of papers in this field.

Oh and this might help that make more sense:

Chronic potassium depletion increases adrenal progesterone production that is necessary for efficient renal retention of potassium
http://www.sciencedirect.com/science/ar ... 0382#f0020

So taking 17-b Estriadol comes with a small cancer risk right? But for people like me who have low Progesterone as well as low Estriadol might a combination estrogen-progesterone preparation be a viable treatment option? A combination treatment doesn't come with the same cancer risk

Ghost wrote:Oh and this might help that make more sense:

Chronic potassium depletion increases adrenal progesterone production that is necessary for efficient renal retention of potassium
http://www.sciencedirect.com/science/ar ... 0382#f0020

This is interesting, I have high DHEA, Aldosterone(both adrenals) and my potassium is in the lower range.

I have low potassium and high progesterone, should I therefore take potassium supplements for PSSD?

Eating a lot of bananas should raise potassium levels.

Ghost wrote:Some new literature that people may like:

http://www.kidney-international.org/art ... 5027-8/pdf

And then a little bit of what I wrote about it elsewhere on the internet:
(BTW this is in response to a topic talking about potassium. It can be found in full here: https://www.hackstasis.com/viewtopic.ph ... 5377#p5377)
...


I'm getting more and more interested in the K+ theory because it appears to be tied to Progesterone. Modulating Progesterone has been a long-term goal of mine becuase I think that it's sufficient to cause the downstream SERT density decreases and 5-HT1A autoreceptor desenitization that I still beleive causes a lot of our PSSD symptoms. Note also that Serotonin can do a lot in and out of the brain, and that this could be doing things too. Once you show that something can increase Prog, I can tie it to each and every PSSD (and basically PFS honestly) symptom.


I searched and searched for something that would control Prog, because I think that might be the next layer of the preverbal "onion" in the PSSD puzzle.

Special note here to the studies below that I highlighted, but I will include a few extra just to back up the claims that it all seems to be part of a bigger cascade, which is outlined at: https://pssdlab.wordpress.com/neurohormone-theory/

This is why Estrogen and Testosterone can reverse PSSD in rats. When people on the PSSD forum tried Estrogen, some had total symptom reversal. The problem is the cost, the danger, the hassle, and it doesn't seem to last. This means dig a step deeper. If Estrogen is protecting SERT in the POA, then find out what could mess with that. As expected, Prog can. So if we can tie that a step further backwards into K+ levels, then f*** me we're golden.



Effects of progesterone on the sexual behavior of castrated, testosterone-treated male cynomolgus monkeys (Macaca fascicularis).
https://www.ncbi.nlm.nih.gov/pubmed/9226343

Progesterone decreases mating and estradiol uptake in preoptic areas of male monkeys.
https://www.ncbi.nlm.nih.gov/pubmed/11790421

Enhanced Sexual Behaviors and Androgen Receptor Immunoreactivity in the Male Progesterone Receptor Knockout Mouse
https://academic.oup.com/endo/article-l ... .2005-0490




Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain.
https://www.ncbi.nlm.nih.gov/pubmed/9105666

SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake.
https://www.ncbi.nlm.nih.gov/pubmed/19157982

Serotonin Clearance In Vivo Is Altered to a Greater Extent by Antidepressant-Induced Downregulation of the Serotonin Transporter than by Acute Blockade of this Transporter
http://www.jneurosci.org/content/22/15/6766.full

Evaluation of Endocrine Profile and Hypothalamic-Pituitary-Testis Axis in Selective Serotonin Reuptake Inhibitor-Induced Male Sexual Dysfunction.
http://journals.lww.com/psychopharmacol ... and.9.aspx

Antidepressant-induced internalization of the serotonin transporter in serotonergic neurons
http://www.fasebj.org/content/22/6/1702.full

5-HT1A Receptor Function in Major Depressive Disorder
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736801/

Effects of Chronic Antidepressant Treatments on Serotonin Transporter Function, Density, and mRNA Level
http://www.jneurosci.org/content/19/23/10494.full.pdf

High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People.
http://www.ncbi.nlm.nih.gov/pubmed/25497691

Serotonin transporter SERT mRNA and binding site densities in male rat brain affected by sex steroids. http://www.sciencedirect.com/science/ar ... 8X98002812

...

A question that I do have.

Chicken or the egg? High Prog or Low K+?

Which comes first, and I honestly don't know enough of this literature to say yet... Does K+ decrease Prog receptors? I thought I had read that here? The study above seems to paint a different picture: that lowered K+ increases Prog levels. It doesn't seem to me that decreasing Prog would lower receptor levels, but again maybe I'm missing something and I admittedly have only looked at a handful of papers in this field.

I'm sure progesterone is altered in pssd
I tried low ssri dose last month, and it made my balls numb, like when I used to smoke weed. 1 month passed, and it's not numb anymore, but my libido is lower than before this low ssri trial.
When I used to smoke weed, I remember I used to feel a similar numbness. Weed increases progesterone by A LOT.
I don't visit this forum regularly. Do you guys found something important about prog?

btw, modafinil is the only drug that made me feel hornier. It increases cAMP in some areas of the brain
but moda causes depression on me

I'll try forskolin soon