Estradiol-17B

Post any data on Treatments and experimentation.
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lost_soul
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Estradiol-17B

Unread post by lost_soul »

Started off on 26th April with way too high a dose and also using DHT, after reading the study (https://www.researchgate.net/publicatio ... omipramine) I decided to stop using DHT and lower the estrogen dose.

I took inconsistent dosages for a while and to be honest I have not been doing this the right way, even so I have noticed big improvements in libido, sensitivity/sensation, flaccid hang and erectile function (but nowhere near a complete reversal of PSSD).

Current dose is 2mg oral estradiol hemihydrate once per day.

One issue that has not been improved by estradiol is my inability to get any kind of erection while sitting or standing up. This was not an issue for me prior to PSSD. If anyone has information about that, please PM me.
Last edited by lost_soul on Mon May 15, 2017 5:27 pm, edited 7 times in total.
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
Bigmum
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Re: Estradiol and DHT

Unread post by Bigmum »

Don' t worry when you get water retention and start smell like woman you will forget about pssd for a while... Today I had gut like elephant;)
Sorry for my bad (terrible) English.
Juvo
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Re: Estradiol and DHT

Unread post by Juvo »

Hoping for the best
forexworld12
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Re: Estradiol and DHT

Unread post by forexworld12 »

lost_soul wrote:Might as well make a thread. Dosages and so on are experimental.

Day 1: 4mg estrofem at night, no changes
Day 2: 6mg estrofem at morning, felt emotional and had stomach butterflies all day, probably placebo. Maybe 5 grams andractim in the afternoon, flaccid hang is a bit better than usual, probably placebo.

I'll try and update every day
lot soul you could update every 5 days. that would be way better and please don't complain until and unless you have trialed it for 3 weeks minimum. I would do anything just to feel emotions and remove the apathy
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lost_soul
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Re: Estradiol and DHT

Unread post by lost_soul »

forexworld12 wrote:
lost_soul wrote:Might as well make a thread. Dosages and so on are experimental.

Day 1: 4mg estrofem at night, no changes
Day 2: 6mg estrofem at morning, felt emotional and had stomach butterflies all day, probably placebo. Maybe 5 grams andractim in the afternoon, flaccid hang is a bit better than usual, probably placebo.

I'll try and update every day
lot soul you could update every 5 days. that would be way better and please don't complain until and unless you have trialed it for 3 weeks minimum. I would do anything just to feel emotions and remove the apathy
OK.

Does no one have any advise for dosing? I find it weird that there's 50+ posts extensively discussing the science of this in the rat study, yet no one seems to have looked into how much a human should take.
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
Kk88
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Re: Estradiol and DHT

Unread post by Kk88 »

Not sure on dosing and I imagine people are reluctant to make recommendations as this is a new experiment

What are the recommended doses for the individual products, for their usual use? Perhaps start with those and then you can look at building up
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Ghost
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Re: Estradiol and DHT

Unread post by Ghost »

I hesitate on advising dosing because I don't feel comfortable giving advise that in theory should be from a doctor. I would note the dose that I might take, but again, I don't know enough about this field yet.

It's also different for the route of administration, and possibly the brand of the drug. All of these factors are very important.

Whatever packaging came with the medication should be able to give much better advice than me or anyone on the forum.

The rats were injected directly into the bloodstream, and I'm assuming that your medication is oral. That makes the conversation between the two impossible without an afternoon of research into the conversation rate between the different types of administration, which is a research field in and of itself.

So I think the best thing to look at is the packaging, and if that tells you nothing. Google doses for different treatments in humans. Also, the pill will likely be in a size that starts fairly small. So taking 1 or .5 of one might be a good start, and then working up to the dose you needed.
- Medical Student & Friendly poltergeist - Lexapro Sept '14. [Hx] [PSSD Lab] [r/PSSD] [Treatment Plan] - Add "Ghost" in replies so I see it :)
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lost_soul
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Re: Estradiol and DHT

Unread post by lost_soul »

Quick update: my estrogen/dht use has made things worse, I think I was taking way, way too much. I will wait a bit and hopefully things will return to baseline, then I will try with far smaller doses.

Ghost, any ideas you have about dosing I would want to know. You're not acting in a professional capacity, you aren't liable for what I do. It would be interesting to know the doses that you would take from a theoretical standpoint.
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
Kk88
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Re: Estradiol and DHT

Unread post by Kk88 »

Worth noting that I felt SJW made me worse for the first couple of days. I suppose like anything (even ssris) you might feel bad for a few days as your body gets used to things. Certainly if we find a solution for this I'd imagine it to make us feel bad to start with, after all we're trying to make the same quote significant changes to our bodies as ssri did, in reverse.


But there's no harm in starting small and building up so yes would suggest you cut down for now and then build gradually
Bigmum
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Re: Estradiol and DHT

Unread post by Bigmum »

IF you start get water retention start heavy exercises... When i got my gut like baloon after estradiol i d made 3km sprint up Hill on my bicycle it helped but few days later the same....
Sorry for my bad (terrible) English.
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