useful for PE

[Kael]

FOUND ON REDDIT ABOUT PE

https://www.reddit.com/r/MaleDefinitiveGuide/


FOR BUILDING STRONGER ERECTIONS AND VASCULAR RESPONSE
These target nitric oxide, endothelial function, and sustained tumescence even under motion.

L-Citrulline

Acutely increases Nitric Oxide (NO). Works synergistically with Pycnogenol.

Dose: 6g - 9g

Taken: In the morning OR 1 hour prior to your training session with food or a beverage.

Pycnogenol

Boosts NO availability. Use with L-Citrulline to replicate clinical ED trial combo.

Dose: 100mg - 150mg

Taken: In the morning with food

Horse Chestnut (Aescin at least 20%)

Improves venous return, which helps reduce erection collapse during and post-training session. Also assists in helping position-dependent erectile dysfunction.

Dose: 400mg - 600mg

Taken: In the morning with food

***Icariin (Epimedium Extract. AKA "Horny Goat Weed")

Icariin is the active flavonoid in Epimedium that mimics the effects of PDE5 inhibitors (like Viagra), though weaker. To get a meaningful PDE5 inhibition effect—strong enough to boost erection hardness, you need at least 80mg-100mg of icariin per dose, ideally once daily on training days. This translates to:

Dose:

250mg of a 40% standardized extract

500mg of a 20% extract

1,000mg of a 10% extract

Most OTC Horny Goat Weed products range between 10% - 20%, which means you'd need 500mg-1,000mg minimum to reach useful icariin levels. (Though there are some out there that reach 40%.)

Taken: In the morning with food or taken 1 hour prior to your training session (while potent, use extra caution taking on an empty stomach, as intestinal upset may occur for some men).

Ubiquinol (Active CoQ10)

Mitochondrial fuel for endothelial health. Supports erection duration, especially during extended sessions.

Dose: 100mg - 200mg

Taken: In the morning with food

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FOR FASTER NEUROPLASTICITY AND NERVOUS SYSTEM ADAPTATION
These expedite long-term skill encoding, pleasure tolerance, and sexual control re-rewiring.

***7,8 DHF (7,8 - Dihydroxyflavone)

Mimics BDNF (brain-derived neurotrophic factor), which is the brain’s primary molecule for strengthening synaptic connections and forming new circuits. That means: your nervous system adapts faster to arousal control, you build new pleasure tolerance patterns more efficiently. and you can override old orgasm reflexes and replace them with edging behaviors more quickly. In short, you progress significantly faster. This is the most potent and powerful non-prescription neuroplastic supplement out there.

However, this supplement is very risky -- it is HIGH RISK, HIGH REWARD. BDNF doesn't discriminate, so if you:

Orgasm during training

Panic, feel frustration, or associate fear with edging

Lose control and emotionally spiral after a session

Then 7,8 DHF can hardwire that negative experience into you just as efficiently as a positive one. (There is a reason I didn't use this supplement myself and didn't include it in the original guide).

Dose: 25mg

Taken: On an empty stomach 1 hour before your session. Must be cycled -- no more than 5 days of consecutive usage without at least 2 days break.

Uridine Monophosphate

Encourages new synapse formation quicker, dopamine receptor sensitivity, and phospholipid turnover.

Dose: Start off at 50mg, no more than 100mg (especially if you are also taking CDP Choline). Yes the dose is very small, it is that potent. You will most likely need a special scale if you want to take this supplement (they are cheap online).

Taken: In the morning with food or beverage. Must be cycled -- no more than 5 days of consecutive usage without at least 2 days break.

CDP Choline (Citicoline)

Supports acetylcholine + dopamine synergy. Enhances focus and sexual memory trace reinforcement.

Dose: 250mg

Taken: In the morning with food. Must be cycled -- no more than 5 days of consecutive usage without at least 2 days break.

ALCAR (Acetyl-L-Carnitine)

Boosts mitochondrial energy and neurorepair. Also improves penile nerve conductivity.

Dose: 1,000mg - 1,500mg

Taken: In the morning with food or beverage. Must be cycled — no more than 5 days of consecutive usage without at least 2 days break.

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FOR AROUSAL BOOSTING/CONTROL
This group enhances pleasure modulation, libido recovery post-orgasm (if any), and prevents overstimulation or burnout.

(Note: I am aware of supplements that boost serotonin. However, between SSRI's and supplements like L-Tryptophan, Rhodiola Rosea, 5-HTP, SAMe, etc. I've elected to not list them as too much serotonin can flatten libido, weaken erections, and blunt-dopamine-based arousal. We don't want anything blunting dopamine, we want dopamine to be high BUT ALSO efficient. We don't want to be numbed to it. Yes, there is such a thing as dopamine that is too high; your training is designed to modulate it).

***Dopa Mucuna (L-Dopa)

Exogenous form of dopamine. You take it, you get dopamine immediately. Restores dopamine after failures, post-orgasm, or if motivation just feels flat. Taking this too much will lead to dopamine desensitization and dysregulation.

Dose: 100mg - 200mg L-Dopa

Taken: Very rarely and as a last resort. Do not take after every failed session/orgasm. Do not take more than 2x a week.

L-Tyrosine

Precursor to dopamine (NOT an exogenous form of dopamine). Helps sustain drive during long edging sessions without crashing. Makes dopamine usage more efficient.

Dose: 1,000mg - 2,000mg

Taken: 1 hour prior to your training session (taken on an empty stomach helps and is mostly well-tolerated with no side effects). Must be cycled -- no more than 5 days of consecutive usage without at least 2 days break.

Damiana Leaf Extract (tincture)

Mild GABAergic and libido enhancing. Helps with relaxed arousal and emotional intimacy focus. In other words, helps you "get horny" if you don't feel aroused - very fast onset.

Dose: 2ml sublingually

Taken: 1 hour prior to your training session as needed. No need for cycling but do not overly rely on it every day.

Agmatine Sulfate

NMDA modulator. Assists in dampening overstimulation and involuntary orgasm reflex thresholds. Use with caution—can flatten arousal if overdosed.

Dose: 500mg

Taken: In the morning with food or at night with food.

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FOR SLEEP OPTIMIZATION AND RECOVERY
These support parasympathetic nervous system dominance, deep sleep, and CNS repair post-training. As I said in the Definitive Guide, if you are not sleeping efficiently, your progress will be stalled/delayed. Sleep (especially REM) is where the magic happens.

Glycine

Improves sleep latency and quality via NMDA modulation. May also subtly boost GH release.

Dose: 3,000mg up to 6,000mg

Taken: At night

Magnesium L-Threonate (Magtein)

Supports synaptic density and sleep quality; the only form of Mg that crosses the blood-brain barrier.

Dose: 2,000mg (144mg of elemental Mg)

Taken: At night

P-5-P

Cofactor for serotonin, dopamine, and GABA synthesis (NOT a serotonin booster). Helps with dream vividness and REM.

Dose: 20mg - 50 mg

Taken: At night

PEA (Palmitoylethanolamide)

Reduces neuroinflammation, promotes restful sleep, improves nerve recovery. (BONUS: Expedites recovery from THC/cannabis use and alleviates T-Break symptoms faster).

Dose: 300mg - 600mg

Taken: In the morning or evening with food, preferably a meal with healthy fats (peanut butter, olive oil, etc.) as it is fat soluble.

BCP (Beta-Caryophyllene)

CB2 agonist (not psychoactive) and anti-inflammatory, promotes calmness and sleep recovery, especially after heavy stimulation.

Dose: 100mg - 300mg

Taken: At night

L-Theanine

Promotes relaxed alertness by increasing alpha brain waves and calming glutamate overactivity, which helps you stay emotionally stable and focused during training without triggering anxiety, premature spikes, or post-session mental crashes.

Dose: 100mg - 800mg

Taken: At night for higher than 200mg doses to help with sleep OR 1 hour before training for 100mg - 200mg doses if you are prone to anxiety, overstimulation or racing thoughts during high arousal spikes.