Quetiapine and Premature Ejaculation

[SeroquelTroubles]

I noticed a major issue arising with premature ejaculation since I was started on quetiapine XR (Seroquel) mono therapy 300mg/day 5 years ago for bipolar disorder. My psychiatrist added 100mg sertraline, which definitely helped the PE, but caused minor ED. I was switched to escitalopram 20mg in 2020, but since January 2021, I tapered off the escitalopram. I noticed definite improvement in ED, but worse PE again. I am now medication free after tapering the quetiapine XR and some improvement in PE. Has anyone else experienced issues with PE while on Seroquel? Could this be due to an increase in prolactin even though the medication is supposed to be PRL-sparing? I feel much better off the medication and am glad I stopped. I am considering using 100mg 5-HTP for both mood and residual PE. I think the Seroquel was a major cause of my PE. Any thoughts? For PE I am using topical lidocaine these days instead of any pharmacological treatments.

[OCDemon]

Rexulti, an atypical antipsychotic, caused PE for me, as well as a host of other issues (soft glans during erection, unsatisfying orgasm, and going flaccid immediately upon beginning ejaculation, to the point of finishing ejaculation while flaccid).

Rexulti is different from Seroquel but I have no doubt these meds can cause crazy issues with sexual function. It's not as well known as with SSRI's but people like you and me are clear examples that they can be just as destructive.

Looking on Wiki, Seroquel shares the same property as Rexulti, in agonizing 5-HT1A and antagonizing 5-HT2C. The PE issues I got from Rexulti were extremely obvious, very markedly different from anything I had experienced before, and have continued to last two years after discontinuing it. My guess is the 5-HT1A agonism is the biggest culprit but the 5-HT2C antagonism could be another. Lots of mechanisms of action here but it has primary effects on serotonin receptors known to have a critical function in ejaculation latency.

[Chetg31]

It seems like Seroquel (quetiapine) could indeed be a contributing factor to your premature ejaculation (PE), as antipsychotics are known to affect sexual function due to their impact on neurotransmitters and hormone levels, including prolactin. The improvement you noticed after stopping the medication supports this. For your PE, using topical lidocaine may be helpful in managing it, but it's also worth considering other non-pharmacological approaches, like behavioral techniques.

As for me, I also deal with PE and use Priligy (Dapoxetine) to manage it. Priligy works by increasing serotonin levels in the brain, which helps delay ejaculation. I take it approximately 1 to 3 hours before sexual activity, usually with a glass of water. It has been very effective in improving my control and reducing the anxiety related to PE. I order it from a trusted pharmacy, health-delivery24.com/?product=priligy, where I always get the best prices and high-quality medication. If PE continues to be a major issue for you, consulting a specialist for targeted treatment might be beneficial.