Agomelatine as a potential treatment for post SSRI anhedonia

[pat-ml]

The user /u/ThatDamnVikingGirl claims to have successfully treated her antidepressant-induced anhedonia using agomelatine (Valdoxan).

I have exactly the same problem, following antidepressants. I had : anhedonia (totale anhedonia), lost my inner voice, tremors, cardiovascular problems, and totale insomnia. I took psy drugs for a very short period of time.

My symptoms never improved with time, but I found another drug myself who helped me with anhedonia (Valdoxan), I recovered something like 80% of my emotions, so the situation is not totally desperate.

https://www.reddit.com/r/neuro/comments ... &context=3

[Sb919]

Not the first time I've heard of this. I wonder if anyone else has given it a try.

This report claims something similar. Sadly it is not approved in the US.
https://onlinelibrary.wiley.com/doi/ful ... /pcn.12032

[ErgogenicHealth]

I am very tempted to trial this compound soon.

[bockemossen]

I really liked Agomelatine. It consistently gave me a warm and pleasant feeling every night I took it. For several years. I only took it 5 days a week, maybe that stopped tolerance. Definitely helped with anhedonia but not emotional numbness I think. This was just acute effects after taking the pill. But I think it helped with depression/anhedonia in the daytime as well. Made me groggy in the morning though.

[Thomas]

What about taking melatonin, then?
Some people (including me) feel better with melatonin.

[bockemossen]

It's the 5ht2c antagonism that relieves anhedonia. Not the melatonin receptor agonism. But if it's correcting bad sleep/circadian rhythm maybe that has an effect.

[Thomas]

It's the 5ht2c antagonism that relieves anhedonia.

Ok, but Agomelatine is quite weak as 5HT2C antagonist. Mirtazapine and mianserin are way stronger if this is what you are looking for.

[bockemossen]

It's the 5ht2c antagonism that relieves anhedonia.

Ok, but Agomelatine is quite weak as 5HT2C antagonist. Mirtazapine and mianserin are way stronger if this is what you are looking for.

Yes it is. Still, I felt almost recreational effects from it acutely. I haven't felt anything like that with melatonin. Mirtazapine and mianserin seems risky though. And a lot more dirty.

[Breathdeep]

Anyone else have any feedback on agomelatine?