An Excellent Explaination of How SSRI's Inhibit Sert

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Tree
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Re: An Excellent Explaination of How SSRI's Inhibit Sert

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The up-regulation of miR-16 and the down-regulation of pre/pri–miR-16 triggered by fluoxetine in raphe were both eliminated by either Wnt3a, LiCl, or SB-216763

https://www.science.org/doi/10.1126/science.1193692
Tree
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Re: An Excellent Explaination of How SSRI's Inhibit Sert

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"Fluoxetine suppressed a LiCl-induced increase of total β-catenin and a LiCl-induced decrease of phosphorylated β-catenin in a dose-dependent manner"

"fluoxetine enhanced binding of β-catenin with Axin1, which is a scaffold protein forming the degradation complex for β-catenin."

https://www.ncbi.nlm.nih.gov/pmc/articl ... ondrocytes.
Tree
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Re: An Excellent Explaination of How SSRI's Inhibit Sert

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"Individuals receiving citalopram only showed an increase in the expression of mir-16 while administration of sertraline led to a significant increase in the expression of mir-16 and a decrease in mir-124 and mir-132 (P<0.05)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311976/
Tree
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Re: An Excellent Explaination of How SSRI's Inhibit Sert

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desoxo-narchinol A extracted from Nardostachys jatamansi DC upregulates sert and reverses the sert inhibition of SSRIs.

"Among which, kanshone C of aristolane-type sesquiterpenoid inhibited SERT most strongly, while desoxo-nachinol A of nardosinane-type sesquiterpenoid instead enhanced SERT potently".

https://www.nature.com/articles/s41598-017-15483-6

"Antagonistic results showed that chlorogenic acid and desoxo-narchinol A reversed inhibition effect of fluoxetine on SERT"

https://www.researchgate.net/publicatio ... tamansi_DC
mhugh
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Re: An Excellent Explaination of How SSRI's Inhibit Sert

Unread post by mhugh »

How can we aquire Desoxo-narchinol A and what would be the optimal dosage to restore SERT function ?
Tree
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Re: An Excellent Explaination of How SSRI's Inhibit Sert

Unread post by Tree »

mhugh wrote: Mon Mar 25, 2024 5:45 pm How can we aquire Desoxo-narchinol A and what would be the optimal dosage to restore SERT function ?
I don't have access to the full study. Maybe someone on this forum can access the full study for us.
Titeuf
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Re: An Excellent Explaination of How SSRI's Inhibit Sert

Unread post by Titeuf »

Tree wrote: Wed Apr 10, 2024 4:07 am
mhugh wrote: Mon Mar 25, 2024 5:45 pm How can we aquire Desoxo-narchinol A and what would be the optimal dosage to restore SERT function ?
I don't have access to the full study. Maybe someone on this forum can access the full study for us.
https://www.sciencedirect.com/science/a ... via%3Dihub

I think that’s what you’re looking for, right?

There are capsules, I don't know if they are as effective.

Is the effect permanent or do you have to continually take the molecule?
Titeuf
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Re: An Excellent Explaination of How SSRI's Inhibit Sert

Unread post by Titeuf »

Tree wrote: Wed Apr 10, 2024 4:07 am
mhugh wrote: Mon Mar 25, 2024 5:45 pm How can we aquire Desoxo-narchinol A and what would be the optimal dosage to restore SERT function ?
I don't have access to the full study. Maybe someone on this forum can access the full study for us.
https://www.wikiphyto.org/wiki/Nard_de_l'Himalaya
Tree
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Re: An Excellent Explaination of How SSRI's Inhibit Sert

Unread post by Tree »

Titeuf wrote: Wed Apr 10, 2024 3:05 pm
Tree wrote: Wed Apr 10, 2024 4:07 am
mhugh wrote: Mon Mar 25, 2024 5:45 pm How can we aquire Desoxo-narchinol A and what would be the optimal dosage to restore SERT function ?
I don't have access to the full study. Maybe someone on this forum can access the full study for us.
https://www.sciencedirect.com/science/a ... via%3Dihub

I think that’s what you’re looking for, right?

There are capsules, I don't know if they are as effective.

Is the effect permanent or do you have to continually take the molecule?
I'm not sure about the details like dosage or it's efficacy. All I know is I've never found a compound studied shown to reverse sert inhibition of an ssri before. I've researched pssd for years too. I'd be willing to try but it seems you can only buy it from research labs unfortunately.
mhugh
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Re: An Excellent Explaination of How SSRI's Inhibit Sert

Unread post by mhugh »

Thanks I will to see in the study.

I think this is the key honestly I wish I could get some.

I think the effects are permanent in the sense that they upregulate the downregulated SERT in the raphe nuclei. SO theoretically you can take a round of it and upregulates your SERT and keep it upregulated as long as you don't mess them up again with SSRI.

There is no other substance that we know of that up regulates them in the Raphe. Some of the theories I've read on here speculate due to the downregulation there excess serotonin is there and has downstream effects the acts as a high serotonin feedback loop.

Cyproheptadine works to lower serotonin and upregulate 5 ht1 a receptor but it is a futile exercise without proper functioning SERT unless you take it continually which for many of us is undesirable. You can upregulate with cyproheptdatine but I think as long as your SERT in the raphe is downregulated your brain will downregulate the receptor again because of the excess.

By all means I don't think it effects everything as a cure all. I think gut microbiome and neurosteroids, epigentic expression play a role too and perhaps the treatment will have to be multi facetted to fix everything but I think if we tried this we would see improvements. I think the Sert levels in the raphe may upregulate naturally as the brain try's to achieve homeostasis but I think this push might be needed from a substance to really get to pre ssri levels.

Anyways hopefully can try this.
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