Spinal tap and 100% resolution of PSSD

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TalkingAnt
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Re: Spinal tap and 100% resolution of PSSD

Unread post by TalkingAnt »

Yes, one can have a deletion of the CYP2D6 gene, leading to total absence of this enzyme. The linked paper suggests it is 4-6% occurrence in some ethnicities. But it is more common to have a mutation leading to reduced expression or function. And one would have to inherit the gene deletion from both parents to have zero CYP2D6. But even if you had zero CYP2D6, SSRIs can be metabolized by other P450 enzymes (as mentioned in the quote you posted), albeit at a slower rate. There is just no way SSRIs stay in your system long after cessation. It would be trivial to take a patient's blood sample (or spinal fluid) to demonstrate this if it were the case, yet the pharmacodynamics have already been studied in detail.

Lastly, if you're going to accuse me of being a shill for pharmaceutical companies despite the fact I've been a member of this community for nearly a decade and volunteer my time and money to keep this website running, which surely looks bad for SSRI manufacturers, then you are going to have to find another community to chase your irrational theories in.
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FindGoodNickname
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Re: Spinal tap and 100% resolution of PSSD

Unread post by FindGoodNickname »

Wow, even chat.openai agrees with you:

It says:

It is plausible that the spinal tap could have had an effect on the individual's PSSD symptoms. While there is no conclusive evidence linking spinal taps to temporary relief of PSSD symptoms, it is known that spinal taps can remove cerebrospinal fluid, which contains various neurotransmitters, including serotonin. Removing excess serotonin may have led to the temporary resolution of PSSD symptoms, but more research would be needed to confirm this hypothesis.

It also says:
One possible mechanism that could explain the temporary resolution of PSSD symptoms following a spinal tap is related to the activation of the nervous system. The spinal tap procedure can be an invasive and uncomfortable procedure that may activate the sympathetic nervous system, which is responsible for the "fight or flight" response. Activation of the sympathetic nervous system can lead to a release of norepinephrine and other neurotransmitters, which can have various effects on the body, including on sexual function. It's possible that the activation of the nervous system during the spinal tap procedure may have temporarily counteracted the underlying mechanism causing the individual's PSSD symptoms.
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