PSSD risk proportional to potency of SERT inhibition

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prop
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PSSD risk proportional to potency of SERT inhibition

Unread post by prop »

Someone on Reddit crunched some numbers to show (if I'm reading this correctly) PSSD is caused by SERT inhibition and not interactions with unintended binding-targets.

https://www.reddit.com/r/PSSD/comments/ ... isk_rates/
Archive of PSSD recovery stories: https://pssd.netlify.app/
DeepRacer
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Re: PSSD risk proportional to potency of SERT inhibition

Unread post by DeepRacer »

Makes sense I suppose. It must be some downstream effects from inhibiting SERT that is causing this condition similar to how finasteride inhibits 5ar and this inhibition is causes the downstream upregulating androgenic/neurosteroidal effects that create pfs. I wonder though if what’s happening in pfs is what’s happening with pssd.
prop
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Joined: Wed Mar 16, 2022 8:22 pm
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Re: PSSD risk proportional to potency of SERT inhibition

Unread post by prop »

"Relative" PSSD risks, from the link:
20% Zoloft
19% Paxil
17% Celexa
22% Lexapro

11% Prozac
Also from the link:
I think the calculated risk for Prozac is smaller than expected because of selection bias. It was the first SSRI to be approved in the USA.
If true, this indicates that the true cause of PSSD does in fact lie in the serotonin reuptake inhibition, and does NOT have anything to do with liver enzyme inhibition, or secondary, unintended binding targets, or anything more complicated than "serotonin reuptake inhibition causes PSSD".
Archive of PSSD recovery stories: https://pssd.netlify.app/
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