The 40k € goal was reached for the University of Milano-Italy Research study. What comes next? Has anyone spoke to the organizer Francisco Mazzi in years? Does anyone have faith that something will come out of this research?
https://www.gofundme.com/f/27l8qmes5c
University of Milano-Italy Research. Open discussion
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University of Milano-Italy Research. Open discussion
75mg Clomipramine. june-july 2018
(Anxiety/Ocd)
Current symtoms I'm experiencing.
Emotional numbness, Pleasurless activities, Complete sexual system shutdown.
(Anxiety/Ocd)
Current symtoms I'm experiencing.
Emotional numbness, Pleasurless activities, Complete sexual system shutdown.
Re: University of Milano-Italy Research. Open discussion
just posted:
In order to provide an update to the PSSD patients, we wish to recapitulate what we have recently published and what we are exploring.
Our previous observations (Giatti S. et al., J.Med.Chem. 2021), obtained in a post-finasteride experimental model, demonstrated that finasteride is able to interact with off-target proteins (i.e., proteins other than its natural target). In particular, this drug is able to block the limiting enzyme in the formation of the stress hormone epinephrine (i.e., phenylethanolamine N-methyltransferase, PNMT). On this basis, we have explored whether paroxetine was also able to interact with off-target proteins. Data obtained demonstrated that also paroxetine is able to interact with PNMT (Giatti S. et al., J. Mol. Structure, 2022). This finding further confirms our hypothesis (Giatti S. et al., Endocrine, 2018) that PFS and PSSD may share common pathways. We believe that this is extremely important because it can mean that research in PFS may be useful for PSSD and vice versa.
In this line of thinking, we have now explored whether paroxetine treatment, like finasteride (Diviccaro S. et al., Psychoneuroendocrinology 2019) may affect the gut microbiota. As recently demonstrated (Diviccaro S. et al., Psychoneuroendocrinology 2022), also paroxetine is able to alter gut microbiota as well as the steroidogenesis in the colon. As we proposed, these alterations may be related to some of the symptoms observed in PSSD (e.g., sexual dysfunction and mood disorder).
We are continuing to study PSSD in our experimental model, exploring the effect of paroxetine treatment and its withdrawal in the following aspects:
1) Identification of possible genes altered in the hypothalamus (i.e., the brain region more important for neuroendocrine control). To do that we are using RNA sequencing analysis (i.e., an innovative analysis that uses next-generation sequences to reveal the presence and quantity of RNA in a biological sample).
2) Parameters relevant for fertility, such as oxidative stress, inflammation, spermatogenesis processes, the acrosome reaction, viability, and mobility of spermatozoa.
3) Morphology of peripheral nerves, myelination process and intraepidermal nerve fiber density. Indeed, PSSD patients report genital numbness or paresthesia, suggesting peripheral neuropathy. In this context, it is important to highlight that we have demonstrated that PFS patients show peripheral neuropathy (Melcangi R.C. et al., J Steroid Biom Mol Biol 2017).
4) Pathological mechanisms involved in persistent sexual dysfunction.
In order to provide an update to the PSSD patients, we wish to recapitulate what we have recently published and what we are exploring.
Our previous observations (Giatti S. et al., J.Med.Chem. 2021), obtained in a post-finasteride experimental model, demonstrated that finasteride is able to interact with off-target proteins (i.e., proteins other than its natural target). In particular, this drug is able to block the limiting enzyme in the formation of the stress hormone epinephrine (i.e., phenylethanolamine N-methyltransferase, PNMT). On this basis, we have explored whether paroxetine was also able to interact with off-target proteins. Data obtained demonstrated that also paroxetine is able to interact with PNMT (Giatti S. et al., J. Mol. Structure, 2022). This finding further confirms our hypothesis (Giatti S. et al., Endocrine, 2018) that PFS and PSSD may share common pathways. We believe that this is extremely important because it can mean that research in PFS may be useful for PSSD and vice versa.
In this line of thinking, we have now explored whether paroxetine treatment, like finasteride (Diviccaro S. et al., Psychoneuroendocrinology 2019) may affect the gut microbiota. As recently demonstrated (Diviccaro S. et al., Psychoneuroendocrinology 2022), also paroxetine is able to alter gut microbiota as well as the steroidogenesis in the colon. As we proposed, these alterations may be related to some of the symptoms observed in PSSD (e.g., sexual dysfunction and mood disorder).
We are continuing to study PSSD in our experimental model, exploring the effect of paroxetine treatment and its withdrawal in the following aspects:
1) Identification of possible genes altered in the hypothalamus (i.e., the brain region more important for neuroendocrine control). To do that we are using RNA sequencing analysis (i.e., an innovative analysis that uses next-generation sequences to reveal the presence and quantity of RNA in a biological sample).
2) Parameters relevant for fertility, such as oxidative stress, inflammation, spermatogenesis processes, the acrosome reaction, viability, and mobility of spermatozoa.
3) Morphology of peripheral nerves, myelination process and intraepidermal nerve fiber density. Indeed, PSSD patients report genital numbness or paresthesia, suggesting peripheral neuropathy. In this context, it is important to highlight that we have demonstrated that PFS patients show peripheral neuropathy (Melcangi R.C. et al., J Steroid Biom Mol Biol 2017).
4) Pathological mechanisms involved in persistent sexual dysfunction.
Re: University of Milano-Italy Research. Open discussion
A live video on YouTube of the research would be actually good because i don't trust them.
Re: University of Milano-Italy Research. Open discussion
Here is Melcangi talking about PFS research (subtitles enabled)
https://www.facebook.com/AVFassociazion ... qwZ7MhXGHl
This video shows Melcangi and some of the guys from the research team in 2015 struggling with PFS (minute 1:12)
https://fb.watch/f-NJSuoAbh/
https://www.facebook.com/AVFassociazion ... qwZ7MhXGHl
This video shows Melcangi and some of the guys from the research team in 2015 struggling with PFS (minute 1:12)
https://fb.watch/f-NJSuoAbh/
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