PSSD 110% cured (hope it lasts)

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ihatelexapro444
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Re: PSSD 110% cured (hope it lasts)

Unread post by ihatelexapro444 »

What have I done to my brain? It's been 3 days since I last took a dose of cymbalta, and it seems it's still inside my system, pupils still dilated, orgasm still hard to achieve, so hard that I have to flex my muscles to the point of soreness and as though I had an intense workout session, also slight headache, but when it does occur, it's 100%, libido and sensitivity also 100%, maybe more than it should be. Something seems to be blocking the ability to orgasm, it's achievable but extremely difficult. I also have lost anxiety and negative thoughts. This could be bad for me, constantly tugging extremely hard on my genital like this every session... and overflow of neurochemistry, this could lead to an addiction. I have never heard or experienced this before. Anyone got any ideas? Also amphetamine is out of my system already and this session's intensity was just the same as what I wrote above, nearly identical, so I think amphetamine might not be a factor here. Also it went numb for several hours after my first session, and a few hours later it's back to the same intensity, this is extremely strange.

I think the medical term for this is anorgasmia. It says cease of medication that caused this will resolve, I ceased it for about 2-3 days now, and 99% of cymbalta should be out of the system by now, is something causing it to linger longer inside my body?
https://www.verywellhealth.com/anorgasm ... ns-2328525
Integra
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Re: PSSD 110% cured (hope it lasts)

Unread post by Integra »

Don't know why u took Cymbalta. Duloxetine one of the worst ad with pssd. I got many different symptoms from it. Anorgasmia don't pass away in your case
Psychological-Safe15
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Re: PSSD 110% cured (hope it lasts)

Unread post by Psychological-Safe15 »

It changes neurotransmitte, by desensitizing receptor or chemical messenger associated with it or slows down or increases the metabolism of its protein or kill the neuron. So if it is out of system it doesn't matter.

By 2-3 days it doesn't mean it should be out. Its metabolites should be out as well not from blood only from blood plasma as well.
lukejimmy
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Re: PSSD 110% cured (hope it lasts)

Unread post by lukejimmy »

DeepRacer wrote: Sat Jan 15, 2022 4:08 pm
The only way I’ve read of increasing SERT density is by increasing testosterone levels and maintaining them at high levels and having healthy estrogen levels protects from degeneration of SERT. This has been shown I believe by looking at brain scans of people transitioning to different genders and seeing a before and after from hormone replacement ie a female transitioning to a male had higher SERT density after taking testosterone. Getting older also degrades SERT levels I know.
[/quote]

I should add, I remember a bunch of posts on reddit complaining about transitioning with HRT decreasing their orgasm intensity ( seems prominent for MtF) and i'm reading of one FtM claiming " orgasms are much stronger and feel more "complete" on testosterone" in response to one of these MtF posts
Now I don't know if the intensity would recover after discontinuing hormones which wouldn't make it as similar as PSSD/PFS, but it's the only instance I remember coming across that isn't confined to our Post xyz conditions... where orgasm intensity is absent
lukejimmy
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Re: PSSD 110% cured (hope it lasts)

Unread post by lukejimmy »

Integra wrote: Sat Jan 15, 2022 3:08 pm What's the next, pssd 120% cured or 150%?😂
I think he means even more intense then pre-SSRI. I experienced the same over-improvement during a brief reinstatement a couple years ago along with the Anorgasmia (difficulty reaching).
Characteristic of 'Post-Acute Withdrawal Syndrome' right?
ihatelexapro444 wrote: Sun Jan 16, 2022 12:13 am orgasm still hard to achieve, so hard that I have to flex my muscles to the point of soreness and as though I had an intense workout session
Your muscles feel relaxed right? After reinstating? I've read Benzo and Phenibut users complaining about similar. Assuming it would be explained by SSRI's potently increasing of neurosteroids like Allopregnanolone
ihatelexapro444 wrote: Sun Jan 16, 2022 12:13 am It says cease of medication that caused this will resolve, I ceased it for about 2-3 days now, and 99% of cymbalta should be out of the system by now, is something causing it to linger longer inside my body?
https://www.verywellhealth.com/anorgasm ... ns-2328525
Funny you say that's my personal theory of PSSD and has been since the beginning, can't find one person who has even a similar theory despite being so simple and obvious? besides cali_man and brman who almost saw the connection with CYP2D6 https://www.youtube.com/watch?v=WsXxvyfz9ko
lukejimmy
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Re: PSSD 110% cured (hope it lasts)

Unread post by lukejimmy »

Integra wrote: Sun Jan 16, 2022 4:54 am Don't know why u took Cymbalta. Duloxetine one of the worst ad with pssd. I got many different symptoms from it. Anorgasmia don't pass away in your case
If he's cured (hope your are OP) I think he'll be ok waiting longer to climax lol, I know I wouldn't even think about it
Darman
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Re: PSSD 110% cured (hope it lasts)

Unread post by Darman »

ihatelexapro444 wrote: Sat Jan 15, 2022 3:05 pm https://www.reddit.com/r/PSSD/comments/ ... &context=3

Alright, so I don't know if this was some sort of a miracle, but 10 months after my discontinuation of Lexapro, I decided to reinstate 2.5 mg Lexapro for 2-3 days, it made my PSSD worse, so I panicked the next day and took a Cymbalta pill 30mg instead and only once. Several hours later, I felt like something switched in my brain, noradrenaline seems to be increasing, and the penis was gradually getting sensitive, but oddly I could not orgasm (agorgasmia), it was as if I was edging constantly for hours when trying to masturbate, but unable to let it out. Cymbalta is an SNRI, the first time I took Cymbalta in 2019, I also could not orgasm, so I guess this is a normal side effect of Cymbalta for me, I didn't worry about it.

Next day, still unable to orgasm, but libido remained and so did penile sensitivity, I got desperate for an orgasm because of very high sexual urges and edging for hours unable to let it out, I decided to pop a Vyvanse pill hoping it could help release it. Watched a porn vid, and lied in my bed trying to get it to let out for hours, the constant flow of dopamine and noradrenaline from simply touching the penis was insane, its sensitivity seems extremely high at this point, eventually I squeezed every muscle of my body, and psychologically tried to induce a stimuli inside my head to urge an orgasm to come out, imagined myself in the video, or some sick fetish, and holy shit, I felt it erupting, and a bucket of it came out, wetting my entire bed, and the feeling was the best I've ever felt for the entire of my fapping career.

I hope this lasts. I wonder, how do you explain this? This was the first time ever, in those 10 months that I felt an orgasm so powerful, real and legit that it was better than pre-ssri.

*also currently week 4 on wellbutrin, had it along reinstatement.

No supplement used, except for fish oil at random times.

TLDR; Cymbalta(SNRI) + Wellbutrin (NDRI) + Vyvanse (Dextroamphetamine)
Hi. Are you still better? I was thinking of trying to reinstate lexapro myself and read your post. I have some some cymbalta too but really don't want to make things worse, and have never taken it before...
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