sigma receptors

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pii
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sigma receptors

Unread post by pii »

https://raypeatforum.com/community/thre ... ssd.41938/
https://prnt.sc/1ol92kz

https://aspie1983.wordpress.com/
"Inflammatory cytokines upregulate 5-HT2C receptors and the SERT, and sigma-1 agonists block the effects cytokines have on serotonin reuptake and 5-HT2C receptor sensitivity."
pii
Posts: 129
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Re: sigma receptors

Unread post by pii »

Somone read
cdraham
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Re: sigma receptors

Unread post by cdraham »

"sigma is very overlooked in pssd
fluoxetine and other SBSSs can directly alter serotonergic systems through Sigma receptors
Sigma-1 controls SERT and 5HT2C
Yet nobody mentions this receptor
this is unbelievable
Neurosteroids and Progesterone bind to sigma
All PSSD patients have high Progesterone"
Tree
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Re: sigma receptors

Unread post by Tree »

cdraham wrote: Mon Aug 16, 2021 2:18 pm "sigma is very overlooked in pssd
fluoxetine and other SBSSs can directly alter serotonergic systems through Sigma receptors
Sigma-1 controls SERT and 5HT2C
Yet nobody mentions this receptor
this is unbelievable
Neurosteroids and Progesterone bind to sigma
All PSSD patients have high Progesterone"
Not all have high progesterone my levels are low but my pssd is terrible. I'm thinking sigma agonism might provide symptom relief by upregulating sert. I'll be trialing dhea for sigma 1 agonism.
Impermanence
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Re: sigma receptors

Unread post by Impermanence »

But how to explain PSSD during treatment with Sertraline, Fluvoxamine wich are sigma agonist...?
But this may explain why reinstatement could help o cure some people...
I remembered people with donepezil (sigma agonist ad well) with little benefits...
CN9
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Re: sigma receptors

Unread post by CN9 »

Impermanence wrote: Mon Sep 26, 2022 11:43 am But how to explain PSSD during treatment with Sertraline, Fluvoxamine wich are sigma agonist...?
But this may explain why reinstatement could help o cure some people...
I remembered people with donepezil (sigma agonist ad well) with little benefits...
Sertraline is an antagonist acc. to https://en.m.wikipedia.org/wiki/Sertraline

"Sertraline also shows relatively high activity as an inhibitor of the dopamine transporter (DAT)[108][118][119] and antagonist of the sigma σ1 receptor (but not the σ2 receptor).[114][115][120]"

Fluvoxamine would be a potent sigma 1 agonist.

and than there is also sigma 2...
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