Cyproheptadine Thread

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Terabithia
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Cyproheptadine Thread

Unread post by Terabithia »

I want this thread to be specifically for the 5ht2a antagonist cyproheptadine. If PSSD is linked to chronic serotonin syndrome then this would be the drug to take. It’s an OTC first generation anti histamine.

I’ve been taking it for the past two weeks and have seen a marked improvement. I used to be completely numb but now I have close to full sensation.

What have been your experiences on cyproheptadine? I suggest taking 4mg 3x a day for at least two weeks to gauge a response.
PEUS_DEUS
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Re: Cyproheptadine Thread

Unread post by PEUS_DEUS »

Cypro is brilliant. I take 2 or 4 mg 3 hours before bed for 2-3 days. Sensation comes back almost immediately. Emotional blunting is resolved days after quitting once the rebound kicks in. Emotional blunting is only ever fixed for a couple days but sensation lasts a week or so and seems to set a slightly better baseline.
Kk89
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Re: Cyproheptadine Thread

Unread post by Kk89 »

I tried Cyproheptadine 2 years ago. Long story short, I had a strange experience on it where, completely unstimulated, I had the stomach tensing part of an orgasm, with no physical sensation in my genitals. It was like half of an orgasm - really weird. Full post - viewtopic.php?p=34469&hilit=cyproheptadine#p34469

As an aside, I found the sleep-inducing side effects quite unmanageable. How are you overcoming this?
PEUS_DEUS
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Re: Cyproheptadine Thread

Unread post by PEUS_DEUS »

Kk89 wrote: Mon Sep 19, 2022 11:33 am I tried Cyproheptadine 2 years ago. Long story short, I had a strange experience on it where, completely unstimulated, I had the stomach tensing part of an orgasm, with no physical sensation in my genitals. It was like half of an orgasm - really weird. Full post - viewtopic.php?p=34469&hilit=cyproheptadine#p34469

As an aside, I found the sleep-inducing side effects quite unmanageable. How are you overcoming this?
Not OP. But I only take it at night. Personally I find it works better that way for all symptoms unless my target is libido.
Terabithia
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Re: Cyproheptadine Thread

Unread post by Terabithia »

Kk89 wrote: Mon Sep 19, 2022 11:33 am I tried Cyproheptadine 2 years ago. Long story short, I had a strange experience on it where, completely unstimulated, I had the stomach tensing part of an orgasm, with no physical sensation in my genitals. It was like half of an orgasm - really weird. Full post - viewtopic.php?p=34469&hilit=cyproheptadine#p34469

As an aside, I found the sleep-inducing side effects quite unmanageable. How are you overcoming this?
The drowsiness gets better the longer you take it. I’ve been taking it for two weeks now and only experience a little drowsiness and I’m sure it’ll continue to subside the longer I take it.
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AdvencedResearchPL
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Re: Cyproheptadine Thread

Unread post by AdvencedResearchPL »

i used it for 2 weeks. I stopped, I didn't feel my heartbeat which scared me, I was sleepy for 2 weeks.
rmichaelballow
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Re: Cyproheptadine Thread

Unread post by rmichaelballow »

Cypro does a few things, that tricks people into believing Serotonin is at the root of this condition.

1. It lowers prolactin, which may have a positive effect on dopamine.

2. It fosters the release of LH/FSH, which is ultimately going to = more serum test.

3. It's anti-cholinergic, for a brief period, which may come with a cholinergic rebound, which will help erection quality, sensation, and libido for a bit. Acetylcholine is not the primary offender here, but raising it can certainly induce windows.

It's good to understand what cypro is doing, aside from being a serotonin antagonist, to understand your individual profile, and what will ultimately get you better.
sylv
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Re: Cyproheptadine Thread

Unread post by sylv »

The same rebound effect comes from mirtazapine and mianserin. Probably applies to all 5-HT2a receptor inverse agonists. Given that receptor is constantly active ( even without presence of serotonin) in areas responsible for emotional processing ( ACC and prefrontal Cortex) it transient blockade might create some kind of rebound sensitization of these brain areas. Not necessary receptors numbers, but it might be a downstream signalling or neural networks sensitization which increase activity resulting in increased emotional processing.

As for practical consideration.

- It's better to use first acute ( weekly ) dosing than chronic because harm reduction ( risk of akathisia and crashes ) Not everybody can tolerate chronic 5-ht2a blockade which acts as an antidepressant.

this effect increases emotional procession. Hence should not be done when someone is too stressed, in bad health, bad mood, addicted to porn or substances because he will mostly feel negative emotions. IF depressive emotion is overwhelming it might lead to a crash on it's own.

- effect is best exploited to train your brain ( visualisations, learning ), forced occupational work and others OCD controlling methods like meditation and from r/ocd. Alteratively after adding a stimulant this is ideal to make progress in socialization or to push some goal oriented behaviour ( like defined in r/anhedonia. )
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