Modafinil restored cognitive and partly sexual functions in this man after paroxetine

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anacleta
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Modafinil restored cognitive and partly sexual functions in this man after paroxetine

Unread post by anacleta »

I translate a man's message.

After a PhD in Molecular Biology and many years in R&D in pharma I thought I had seen it all. After severe depression for personal reasons, treated with paroxetine 20 mg per day for some time, I had to stop because the treatment blocked my professional life and my creative flow, making it impossible to concentrate. Among other things, as I am sure you know, this SSRI caused me the classic effect of loss of sensitivity of the penis and the phenomenon of very long intercourse (up to three hours). This length of time did not translate into a firm erection, so the doctor prescribed the classic PDE5 inhibitors. All of this was topped off by a lack of interest in my partners. These are all known phenomena. The effects of pssd manifested themselves after a quick interruption of paroxetine with a stop of the drug. Subsequently, after several weeks, I was not able to return to my initial condition. The mental confusion, although attenuated, and the absence of libido were continuous. My feeling was of mental muffling. For me, who has made my work and intellectual activity a source of pride and strength, it was a disaster. I asked my doctor to resume the drug as deparox (the water-soluble mesilate form) to go back to the 20mg dose and then scaling it down by 2mg a week. Unfortunately it didn't work... I also realised that paroxetine and deparox have different effects on me with threshold effects around 7 mg. In August of this year I was depressed by this situation and talking to another doctor he recommended modafinil for the issue of concentration and attention. He told me that it could be taken for a few days or as a spot. I leave it to you to research the effects of the product. I have to tell you I was doubtful knowing it by reputation, never taken it in the past but it has changed my life. Concentration, attention and operability are back to before the SSRIs. The sexual side has been partially restored. Absurdly after a week it was like a reset. I always take PDE5 inhibitors but not consecutively with modafinil as the latter is also a cyp450 inhibitor. In general I don't think I'll be taking any more SSRIs in the future. They have done worse to me. But that's my impression. The doctor said I wasn't getting back to my old self because I was still depressed but for me that was bullshit. In my opinion the metabolism and binding on the riuptake receptors should be studied. My impression is that they are not completely reversible depending on individual polymorphisms. But that's my personal opinion.

Some links on cases of Modafinil and sexual dysfunction (also persistent)

Has anyone ever heard of Armodafinil (or Adderall) permanently killing sex drive?
https://www.reddit.com/r/modafinil/comm ... _adderall/
Modafinil can cause erectile dysfunction?
https://www.reddit.com/r/modafinil/comm ... &context=3
No pleasure during orgasm
https://www.reddit.com/r/PSSD/comments/ ... &context=3
have you tried modafinil?
https://www.reddit.com/r/PSSD/comments/ ... modafinil/
Darman
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Re: Modafinil restored cognitive and partly sexual functions in this man after paroxetine

Unread post by Darman »

I thonk I have taken every suppliment out there. None of them have really helped with the PSSD. I really like Modafinil and I suppose it does help a little, although I have only tried it in isolated cases and never 2 days in a row. Perhaps this may help.
All the best.
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