I got my biggest window from 5ht1a agonism, like DXM high dose, although DXM is very dirty so it could have been a different mechanism
No reaction to MDMA and psychedelics
This makes me think in PSSD there is actually a hypersensitive pre-synaptic 5ht1a autoreceptor, which puts a brake on neuronal 5-HT transmission (also evident by aphantasia, etc)
So when pre-synaptic 5ht1a autoreceptors are hypersensitive, this would lead to high extracellular serotonin which downregulates AR expression
Once you get the receptors right again, AR could potentially still be downregulated (need for upregulation of AR with steroids)
High dose SSRI could potentially knock down pre-synaptic 5ht1a autoreceptors and lead to increase firing and transmission, maybe if you add supraphysiological TRT you could get cured? then taper off very slowly
Did someone trial plain 5ht1a agonism + TRT?
Re: Did someone trial plain 5ht1a agonism + TRT?
hi What doses are you taking dxm?How long does it take?
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