Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

[alteredhomeostasis]

I can’t take 9-me-bc on Prozac but I will add the pomegranate, cialis, and l-histidine to the stack. Why not

[MisterCharlie]

Can people confirm L-Histidine is the same as this: L-Histidine Base Powder? is betahistine better or worse or the same?
Can I skip the cialis? i have terrible headaches on viagra and I read cialis is the same chemical as viagra but lasts for days
Buying Pomegranate juice asap.

Edit: 10/26 Doing like 6 cups of Pomegranate juice a day, starting today, while I wait on the Histidine and an answer about the Cialis. This thread sure got quiet...help us out?
10/27 Felt a small fever early in the morning, slept a couple hours longer than usual, some extra gas. Found out L- histidine is showing up Friday.
10/28 about 5 minutes of morning wood this morning- idk if its from the protocol or improvement from a half a Ropinirole tablet I took saturday, some moodyness (maybe not related), alot of extra tiredness
10/29 got l histidine base powder and ate a big chunk. Still drinking P. juice and might go get some beet root juice. Not noticing too much extra today
10/30, 10/31 L histidine seems to have antidepressant effect. didnt have morning wood this morning, but had a few drinks.

[ryjoseph97]

I am not sure the difference between Lhistadine base powder and Lhistadine HCL but i’ve found Lhistadine HCL to have an extreme antidepressant effect on me.

I just started it three days ago at about 3 grams a day. I no longer have crippling anxiety or toxic shame. Feels much like an ssri except I haven’t experienced any side effects. I wonder if it is restoring some sort of serotonin function. I can’t speak to sexual improvements yet but I can say nothing has gotten worse.

[alteredhomeostasis]

Been taking 5mg of cialis a day for like a week now and after a few days I started to feel really damn good.

I tried the l-histidine but it seemed to kinda take my function down a bit so that’s on the shelf currently.

But it’s crazy how good I feel on the cialis 5mg per day. I’m like feeling energized and refreshed 24/7. Someone else should try this.

[tonyareias]

The problem of Cialis or Viagra is the bad side effects for some people.

[MisterCharlie]

Felt like my health was getting worse, needing excessive sleep, blurry vision, sadness (after feeling an antidepressant effect). Apparently you should only take 500mg-1 gram dosage of L hisitidine a day. It blocks your absorption of folic acid, iron, and zinc. So I would advise supplementing with folic acid and zinc. High dosages (4grams a day or more) are also linked to retarded growth, enlarged liver, and high cholesterol levels.Im going to take L-hisitidine every 3 days. 500mg or 1 gram.

two good links:
https://community.bulksupplements.com/l-histidine/
https://www.verywellhealth.com/histidin ... de-effects

edit:
11/4 still taking P juice and l histidine, 9-mbc periodically. I think the histidine base is just alkalized from l hisitidine hcl, and no real difference. Not noticing any extra boners BUT once I get "i get it up" it seems to be staying up easier and longer.
total time so far, 1 week 2 days

[Area1255_2021]

Glad to hear you are getting *some* results Mister Charlie.

[MisterCharlie]

Glad to hear you are getting *some* results Mister Charlie.

Can I get to full recovery without the cialis? I can do this for more than 4 weeks. Thank you for the info!!!

[Area1255_2021]

Glad to hear you are getting *some* results Mister Charlie.

Can I get to full recovery without the cialis? I can do this for more than 4 weeks. Thank you for the info!!!

Not likely. The Cialis is a necessary component to the stack. It sustains the NO-cGMP pathway. Keeping results going steady.

[MindChanger]

Dexmedetomidine facilitates the expression of nNOS in the hippocampus to alleviate surgery-induced neuroinflammation and cognitive dysfunction in aged rats (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343769/).

5-HT(1A)R-selective agonist 8-OH-DPAT and selective serotonin reuptake inhibitor (SSRI) fluoxetine downregulated hippocampal neuronal nitric oxide synthase (nNOS) expression, whereas 5-HT(1A)R-selective antagonist NAN-190 upregulated hippocampal nNOS expression. By assessing anxiety-related behaviors using the novelty suppressed feeding, open-field, and elevated plus maze tests, we show that mice lacking nNOS gene [knock-out (KO)] or treated with nNOS-selective inhibitor 7-nitroindazole (7-NI; i.p., 30 mg/kg/d for 28 d; or intrahippocampal microinjection, 16.31 microg/1.0 microl) displayed an anxiolytic-like phenotype, implicating nNOS in anxiety (https://pubmed.ncbi.nlm.nih.gov/20164327/).

5-HT uptake induces NO production from nNOS physically linked to SERT, through a calmodulin (CaM)-dependent mechanism. NO formed in association with 5-HT transport might, through cGMP and cGMP-dependent protein kinase (PKG), phosphorylate SERT, increasing its activity. nNOS, by engaging the cGMP-dependent pathway that enhances intrinsic SERT activity (8), allows for a continual homeostatic fine-tuning of 5-HT uptake according to the ambient extracellular 5-HT concentration: the higher it is, the more rapidly it will be removed. (https://www.pnas.org/content/104/19/7739).

By using [(3)H]5HT, it is reported here that 5HT binds to nNOS, but only when the enzyme is active and in a superoxide-dependent manner. This binding is prevented by DPI but not by L-NAME. The formation of 5HT-nNOS complex was shown to be very well correlated with the production of ROS by 5HT in the presence of nNOS. A mechanism involving nNOS only in its initial step is proposed to explain both the formation of 5HT-nNOS complex and the production of ROS observed in the presence of nNOS and 5HT (https://pubmed.ncbi.nlm.nih.gov/19191108/).

We speculate that NO regulates pLTF by modulating extracellular 5-HT accumulation near phrenic motor neurons. Thus, NO exerts dose-dependent regulation of the balance between opposing serotonergic receptors and their downstream kinases (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361021/).

Activation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstriction (https://www.frontiersin.org/articles/10 ... 00050/full).

5-HT3 activation is reported to increase intracellular cGMP levels,77 which rises the question of how an ion channel could link with this system. Reiser has suggested cytosolic Ca2+ and NO as possible mechanisms. Again, by contributing to NMDA facilitation due to the resulting membrane depolarization, more prolonged effects on the Ca2+ concentration through 5-HT3 activation could be postulated. Furthermore, it is well known that NMDA directly enhances nNOS activity (https://www.sciencedirect.com/science/a ... 1109002118).

Episodic spinal 5-HT receptor activation is sufficient to elicit pMF by an NADPH oxidase-dependent mechanism, suggesting common mechanisms of ROS formation with AIH-induced pLTF.

(5-HT (2A)) receptors increase production of cyclic guanosine monophosphate (cGMP) in slices of rat frontal cortex (https://www.neurotransmitter.net/migrai ... P%20levels.).

Impaired Expression of Neuronal Nitric Oxide Synthase in the Gracile Nucleus Is Involved in Neuropathic Changes in Zucker Diabetic Fatty Rats with and without 2,5-Hexanedione Intoxication (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846497/).

Estrogen deficiency induces compensatory NOS production which may be related to decreases in muscle to collagen ratio in female rabbit genital organs (https://pubmed.ncbi.nlm.nih.gov/11494077/).

Interesting articles, quite relate to this thread.