Pregnancy

[Juvo]

Prozac is reducing the 20a-HSD enzym activity which synthesis 20a-dihydroprogesterone from progesterone on the human brain. And this enzyme is stimulated 24 hours prior to parturation. Problem might beceause of 20a-dhp and progesterone.
Can you find which antidepressant did she used?

https://en.m.wikipedia.org/wiki/20alpha ... ydrogenase
https://www.ncbi.nlm.nih.gov/pmc/articl ... po=54.1667

“The effects of fluoxetine, paroxetine, and imipramine on the enzymatic activity of human 3α-HSD type IIBrain also were determined. Unlike human type III, human type IIBrain did not appreciably convert DHP to allopregnanolone or allopregnanolone to DHP. However, the human type IIBrain had considerable 20α-HSD activity and converted progesterone to 20α-dihydroprogesterone (4-pregnen-20α-ol-3, 5-dione). In addition, human type IIBrain possesses 17β-HSD activity and converts androstanediol to androsterone (Fig. ​(Fig.33A). Fluoxetine affected the Km of the 20α-HSD function of the type II enzyme (Table ​(Table3).3). Fluoxetine, but not paroxetine or imipramine, increased the Km of this reaction from 142 to 238 μM, resulting in a slightly less efficient 20α-HSD activity. Thus, fluoxetine slightly inhibits the side reaction: progesterone to 20α-dihydroprogesterone.”



“20alpha-HSD has been initially described as a progesterone metabolizing enzyme of the ovary. On a functional level, ovarian 20alpha-HSD is actively involved in the control of progesterone homeostasis in pregnancy of rats and mice. While 20alpha-HSD expression and activity is downregulated in the corpus luteum of pregnancy, 24 hrs prior to parturition ovarian 20alpha-HSD activity is acutely stimulated. Accordingly, in mice with targeted deletion of the 20alpha-HSD gene, progesterone blood concentration remain high throughout pregnancy which results in a delay of 2–4 days in parturition. Indicating that expression of 20alpha-HSD activity is mandatory for the induction of parturition through reduction of progesterone blood concentration.”

Nice post