Estradiol-17B

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lost_soul
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Re: Estradiol-17B

Unread post by lost_soul »

Glitch wrote:Yeah, that Rat study doesn't specify whether it was permanent or not. I still don't get how they figured out how to do that with estrogen though. I feel like we are actually close to cracking this.
The thing is, with a small enough dose of estrogen even a male can take it for years without extreme problems (assuming no hormonal irregularities). Maybe it would have to be cycled to prevent permanent changes to test levels. But would such a small dose be effective for pssd, I don't know. Plus you'd have to live a very clean lifestyle which isn't ideal for some of us.

Based on my previous experiences I do think it is temporary, but perhaps not if taken for long enough in the right conditions. Every other use of estrogen I know of, it only lasts while you take it unless you take it for years.

Today I noticed big improvements in erectile function and arousal (response to visual stimuli) buy it only lasted 20 minutes or so. I used a lot of dht this morning and also have only smoked about a third or less of what I normally do so I assume one of those factors is responsible.
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
Glitch
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Re: Estradiol-17B

Unread post by Glitch »

Interesting. How long are you planning on taking Estrogen and Dht? I would probably go until I plateau and then taper off. Then again, I have no idea what i'm doing.
Juvo
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Re: Estradiol-17B

Unread post by Juvo »

If anyone is planning on trying this, get an estrogen panel before trying this if you can swing it. This way we can track how concentrations might change over time.
GIXXER
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Re: Estradiol-17B

Unread post by GIXXER »

So is estradiol-17b the new nystatin? I really hope these results lost_soul is reporting will work for others.
Blackout
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Re: Estradiol-17B

Unread post by Blackout »

I tested for T and E today in the morning and my results came back alredy. My E2, as it has always be with me, is near the upper range 39 (11-44) and T is very low 3.5 (1.75-7.8). And in my blood panel from two days ago, my malabsorption problem is evident as extreme malnourishment; moreover I've slightly elevated unconjugated bilirubin, and my hematocrit continues to be on top of the range while my iron levels are at the bottom. I am far from fit for this, but I want to try...

Can someone tell me if it is possible to take HCG together with E2? My T levels are too low, I've tended to respond to HCG in the past, but I don't want to shut my system off completely with testosterone injections. If I use the estradiol alone, or with the DHT, I'm afraid that my T level gets even lower. Any suggestion?
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Ghost
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Re: Estradiol-17B

Unread post by Ghost »

E2 is unchanged in SSRI patients with sexual dysfunction.

Safarinejad, 2008
Evaluation of Endocrine Profile and Hypothalamic-Pituitary-Testis Axis in Selective Serotonin Reuptake Inhibitor-Induced Male Sexual Dysfunction


"The basal serum E2 values did not differ significantly between the [SSRI with nos sexual dysfunction, and non-SSRI] groups (Table 1)."
- Medical Student & Friendly poltergeist - Lexapro Sept '14. [Hx] [PSSD Lab] [r/PSSD] [Treatment Plan] - Add "Ghost" in replies so I see it :)
Jaxx
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Re: Estradiol-17B

Unread post by Jaxx »

A useful find, but still, most of the SSRI patients with sexual dysfuction, will never develop PSSD.
I would expect that there is a difference between PSSD sufferers and non-PSSD, regardless if they have sexual dysfunction on SSRI. Doesnt really rule out that E2 was changed in our case i guess?
For me, the sexual dysfuction was different after i quit SSRI.
Juvo
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Re: Estradiol-17B

Unread post by Juvo »

Jaxx wrote:A useful find, but still, most of the SSRI patients with sexual dysfuction, will never develop PSSD.
I would expect that there is a difference between PSSD sufferers and non-PSSD, regardless if they have sexual dysfunction on SSRI. Doesnt really rule out that E2 was changed in our case i guess?
For me, the sexual dysfuction was different after i quit SSRI.
I agree about there being a difference. I always had some semblance of libido, even while on SSRI. Now, with PSSD it's like my body lost that pathway or ability altogether. We don't know if it's a separate process than the ones that just have temporary induced dysfunction while on the drugs. Maybe with us the house of cards fell and the body was pushed persistently outside of normal homeostasis. I know we are getting closer and closer to our suspect. If we can confirm benefits from estrogen in others, even if temporary, this is a huge find.
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lost_soul
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Re: Estradiol-17B

Unread post by lost_soul »

Dammit, I gambled away all my money (not much lol). I'm not going to be able to spend any money on new PSSD trials for nearly a month now. Still, there are some things I may be able to get prescribed for free by the doctor.
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
Bigmum
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Re: Estradiol-17B

Unread post by Bigmum »

You can always try fasting it s for free ;)
Sorry for my bad (terrible) English.
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