Estradiol-17B

Post any data on Treatments and experimentation.
marsupial
Posts: 242
Joined: Wed Nov 02, 2016 6:08 pm
Contact:

Re: Estradiol-17B

Unread post by marsupial »

Lost soul please so after suplementing with estradiol your libido increased libido to the point it never was during PSSD? And your erectile dysfunction apear after estrodiol? Do I understand it correctly? Thanks man?
User avatar
lost_soul
Posts: 362
Joined: Tue Apr 11, 2017 10:05 am
Contact:

Re: Estradiol-17B

Unread post by lost_soul »

Since pssd I've had zero libido and total erectile dysfunction, libido has improved tons but ed is still pretty bad. Soft glans most of the time, angle is lower and my dick moves around a lot even when hard (as in its pliable, not throbbing) . Kegels hopefully will help but I think there might be a secondary pssd mechanism not addressed by estradiol. To be honest length and size are not quite what they used to be, but I'm still not getting as powerful erections as I used to so could just be that. And erections still take ages to start and fade away quickly and I can only have them lying down.

My precum function returned tonight. Seminal quantity and force of ejacuation is improving too. Just the ed now is still severe.

The insomnia is continuing, I cannot sleep at all
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
User avatar
lost_soul
Posts: 362
Joined: Tue Apr 11, 2017 10:05 am
Contact:

Re: Estradiol-17B

Unread post by lost_soul »

Could 5-HTTLPR s-allele have some relation to pssd?
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
Blackout
Posts: 121
Joined: Thu Jan 22, 2015 11:48 am
Contact:

Re: Estradiol-17B

Unread post by Blackout »

lost_soul wrote:Since pssd I've had zero libido and total erectile dysfunction, libido has improved tons but ed is still pretty bad. Soft glans most of the time, angle is lower and my dick moves around a lot even when hard (as in its pliable, not throbbing) . Kegels hopefully will help but I think there might be a secondary pssd mechanism not addressed by estradiol. To be honest length and size are not quite what they used to be, but I'm still not getting as powerful erections as I used to so could just be that. And erections still take ages to start and fade away quickly and I can only have them lying down.

My precum function returned tonight. Seminal quantity and force of ejacuation is improving too. Just the ed now is still severe.

The insomnia is continuing, I cannot sleep at all
This is killing me. For the first time in I don't know how many years I feel the urge to try something and not just try 'something else'. Mostly because all this estradiol theory, your results, and my own story related to hormones and PSSD points out to at least something that can ammeliorate this hell. If I was two years younger -less sick- than now, I would be already into this experiment. But I'm very afraid of my poor health and the potential for thrombosis. I much prefer cancer over the possibility to end my days as a vegetable in a bed or something worse. This is the greatest risk I would be taking.
I've been reading lots of old info that says that estradiol replacement and anticoagulants is contraindicated, and just a couple of newer articles that say that there's no increased risk of clots taking both of them. I don't know what to do... The sole idea of getting the opportunity of feeling lust one single day, a week, two, for the first time in more than six years -excluding the strange night in February 2012-. What a nightmare.
Juvo
Posts: 560
Joined: Fri Jan 06, 2017 7:50 pm
Contact:

Re: Estradiol-17B

Unread post by Juvo »

lost_soul wrote:Since pssd I've had zero libido and total erectile dysfunction, libido has improved tons but ed is still pretty bad. Soft glans most of the time, angle is lower and my dick moves around a lot even when hard (as in its pliable, not throbbing) . Kegels hopefully will help but I think there might be a secondary pssd mechanism not addressed by estradiol. To be honest length and size are not quite what they used to be, but I'm still not getting as powerful erections as I used to so could just be that. And erections still take ages to start and fade away quickly and I can only have them lying down.

My precum function returned tonight. Seminal quantity and force of ejacuation is improving too. Just the ed now is still severe.

The insomnia is continuing, I cannot sleep at all
Give it some more time before trying PDE5 inhibitors. Alcohol and cigarettes are also potent erection killers so make sure you are abstaining from those as well
User avatar
Ghost
Posts: 1750
Joined: Wed Jan 21, 2015 11:16 pm
Location: USA
Contact:

Re: Estradiol-17B

Unread post by Ghost »

Start running. Running helps me a lot with sleep.

Eventually your body will collapse and go into REM-rebound.

You could also try things that I use to sleep like Melatonin or Magnesium.

When you say you can't sleep at all, what do you mean by that? How many hours have you slept this week?

Another thing I recommend: meditate. A deep meditative state is similar to sleep in many ways. Could help you get through the lack of sleep for now.

When I don't sleep enough, my PSSD gets better. So that could be playing a role too.
- Medical Student & Friendly poltergeist - Lexapro Sept '14. [Hx] [PSSD Lab] [r/PSSD] [Treatment Plan] - Add "Ghost" in replies so I see it :)
User avatar
lost_soul
Posts: 362
Joined: Tue Apr 11, 2017 10:05 am
Contact:

Re: Estradiol-17B

Unread post by lost_soul »

Update: slept 6 or 7 hours last night. Probably had 30 to 35 total the last week. I don't feel sleep deprived any more. I took some yohimbine and l arginine today and felt hypersexual. Ed was improved quite a bit but still severe. If I stopped smoking and took estrogen cialis and yohimbine every day I could conceivably be pssd free. I will try and buy some cheap generic cialis when I can, anyone recommendations appreciated.

It seemed like more girls than usual were checking me out today too so perhaps the changes are changing my facial expression/body language. Or maybe I'm just more in tune to it.

Having a libido changes your personality so much
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
forexworld12
Posts: 181
Joined: Wed Feb 18, 2015 1:31 pm
Contact:

Re: Estradiol-17B

Unread post by forexworld12 »

Hey lost soul. Hypersexual is not normal. You want a normal libido. i think your estradiol trial is over 3 weeks now and seems to me except erection all areas of sexuality have returned to pre pssd normal level.

What i am more interested in now is if this is going to be in remission if you quit taking it.
User avatar
lost_soul
Posts: 362
Joined: Tue Apr 11, 2017 10:05 am
Contact:

Re: Estradiol-17B

Unread post by lost_soul »

forexworld12 wrote:Hey lost soul. Hypersexual is not normal. You want a normal libido. i think your estradiol trial is over 3 weeks now and seems to me except erection all areas of sexuality have returned to pre pssd normal level.

What i am more interested in now is if this is going to be in remission if you quit taking it.
I know, I'm taking it to help with ed not libido. I'm going to keep taking the estrogen for a few months at least because last time I took it, it didn't last after I stopped. And I am pretty sure I will see even greater benefits after I stop smoking.

So my plans for now are to keep taking estrogen and try and quit smoking, then get some tadalifil (cialis) powder. What I might do is find some estradiol without enteric coating and get some capsules then try and find the perfect dose/frequency for tadalifil and estradiol. Hopefully this will be an effective treatment. I'm confident I can keep taking that for a year with no permanent side effects so I will try and do something like that and see whether the changes last after I stop. Does that sound like a good plan?

Also, if anyone in the uk wants a near full tube on andractim for experimenting with it for pssd, I don't want it anymore so I can mail it to you free of charge.

I think yohimbine and l-arginine must interact with each other. Past the first couple of hours they've made my ed worse together and it feels like I'm speed or a lot of caffeine, shaking a lot. Yohimbine raises blood pressure and l-arginine lowers it, maybe that is why.
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
forexworld12
Posts: 181
Joined: Wed Feb 18, 2015 1:31 pm
Contact:

Re: Estradiol-17B

Unread post by forexworld12 »

Hmmmm first i would like to know is except for erection your libido sensation motivation and orgasm all are 10/10 now? Like completely back to normal human levels?
Post Reply

Who is online

Users browsing this forum: No registered users and 1 guest