Estradiol-17B

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lost_soul
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Re: Estradiol-17B

Unread post by lost_soul »

Coraggio wrote:Very interesting.. Lost soul, can you describe better also how much DHT did you take and for how long? And what about illegal drug that have you taken? maybe it is a mix.. I mean.. Can you describe what have you taken for how long and your point of view about each thing? Thanks if you can..it could be huge!

very glad of hearing improvements by someone
I took DHT at the start, not sure for how long. A week maybe? I was taking way too much of it and too much of the estradiol too. I hope no damage has been done by that. When I was taking those high doses things got worse. I lost my morning wood and that hasn't returned yet :(

Other drug usage is the ones previously mentioned in the thread (to be honest I kept taking ketamine for a while, up to yesterday and I got through a lot of it) and apart from that just alcohol and cannabis and nicotine. Things were really bad for a few days after the amphetamine and mdma use but then went back to normal. I'm thinking about trying slow release amphetamine based medications for libido. I don't know the exact differences off hand, but recreational amphetamine causes both mental and physical affects (the physical ones are ones we'd want to avoid, particularly vacoconstriction) and there are some amphetamine based meds you can get that don't have physical effects (I think dexamphetamine is one).

It isn't a complete reversal like with the rats, but it definitely helps a lot, and I can only hope the benefits will keep increasing the longer I take it.
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
DoIt
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Re: Estradiol-17B

Unread post by DoIt »

Haha this is great, see man, there's still hope. I'm glad for you, best wishes!
Coraggio
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Re: Estradiol-17B

Unread post by Coraggio »

Thanks man, I suggest you to avoid amphetamines and mdma stuff, they can give pssd symptoms in long term too..

I have discovered that human anticonceptional pills, for women, have a beta-estrogen value of 0,030 mg/ day (30 mcg/day)
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Ghost
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Re: Estradiol-17B

Unread post by Ghost »

Yea I'd stay just on the Estrogen for now, and slowly try to wean off of cigs.
- Medical Student & Friendly poltergeist - Lexapro Sept '14. [Hx] [PSSD Lab] [r/PSSD] [Treatment Plan] - Add "Ghost" in replies so I see it :)
GIXXER
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Re: Estradiol-17B

Unread post by GIXXER »

How much ketamine did you use?

I strongly suggest trying one thing at a time when experimenting. How can you be sure whats working and whats not when your running a crazy cocktail of different substances.
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lost_soul
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Re: Estradiol-17B

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I've had a period of a couple of hours now with basically full pre-pssd function and libido. 100% erection, same size as previously pssd but not as long lasting. Only because I'm lying down and tired, standing up during the day it would be impossible. I thought about the girl I used to know and I cried. It's bittersweet. I could feel what I've been missing out on for so long. One weird thing though is the full libido is only there when I think about her. Not a normal libido where seeing an attractive stranger/fantasising about a celebrity or whatever will get you going. I hope all that returns too.

Edit: ketamine use was heavy, 1.5 to 2 grams over 4 or 5 days, to be honest I don't think it has an effect either way, I'm going to stop talking about illegal drug use on here from now on but to be honest I've done a lot of drugs and nothing has permanently affected pssd so I would say it's normally safe.
Last edited by lost_soul on Mon May 15, 2017 11:03 pm, edited 2 times in total.
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
Blackout
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Re: Estradiol-17B

Unread post by Blackout »

I'm really, really, really tempted to try. But since I have a lot of diseases now, don't know if it could help or if it could make my diseases worse -i.e. make them progress into cancer, if I don't have it already. If you don't mind, I'll ask you something more: have you have any change in testicle size while taking estradiol?
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lost_soul
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Re: Estradiol-17B

Unread post by lost_soul »

Blackout wrote:I'm really, really, really tempted to try. But since I have a lot of diseases now, don't know if it could help or if it could make my diseases worse -i.e. make them progress into cancer, if I don't have it already. If you don't mind, I'll ask you something more: have you have any change in testicle size while taking estradiol?
No, but yeah, long term estrogen use will cause problems for men, but I think it takes until a year or so for permanent changes and 2mg is a low dose so possibly a healthy male hormone system can adjust to it without issue. I'm not even bothered if I grow tits or something, I just want my life back

Re cancer, estradiol and high estradiol levels do actually lead to much higher risks of certain cancers in men, and a lower life expectancy in general, also raises the risk of deep vein thrombosis, so if you are elderly and/or have physical health problems that is something to bear in mind
21, male, extreme pssd for four years
Tried inositol (slight improvements) cialis (very limited improvements) yohimbine (slight improvements) maca root (no effect) bacopa monieri (no effect) estradiol-17b (pronounced improvement in all areas of sexuality)
Blackout
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Re: Estradiol-17B

Unread post by Blackout »

lost_soul wrote:
Blackout wrote:I'm really, really, really tempted to try. But since I have a lot of diseases now, don't know if it could help or if it could make my diseases worse -i.e. make them progress into cancer, if I don't have it already. If you don't mind, I'll ask you something more: have you have any change in testicle size while taking estradiol?
No, but yeah, long term estrogen use will cause problems for men, but I think it takes until a year or so for permanent changes and 2mg is a low dose so possibly a healthy male hormone system can adjust to it without issue. I'm not even bothered if I grow tits or something, I just want my life back

Re cancer, estradiol and high estradiol levels do actually lead to much higher risks of certain cancers in men, and a lower life expectancy in general, also raises the risk of deep vein thrombosis, so if you are elderly and/or have physical health problems that is something to bear in mind
I've been waiting death for a long time. I would glady accept to live only one or two more years if I get rid of PSSD or at leat get a lot better. I'm not elderly, I am 34 but with the general health of someone in his seventies. By the way I've had tits all my life, my estradiol was always on the top of the range and that wasn't an issue to have a raging libido pre pssd.

Regarding cancer and my general health worsening since a year and a couple of months ago, maybe the many months I took arimidex -among other things like T3- contributed to the worsening of my gastrointestinal issues. Too little estrogen too can cause cancer, and too late I learned that gastric cancer in particular is related to low estrogen levels.

I'll give just this week to see if you sustain your progress or gets even better, and then I will decide. But please, as everybody has stated, don't add anything else to estradiol while you continue this trial. I did that mistake for years, preparing cocktails of drugs and supplements without any order; it was clear which drugs affected me more, but I maybe didn't let other from helping by mixing them.
forexworld12
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Re: Estradiol-17B

Unread post by forexworld12 »

lost_soul wrote:I've had a period of a couple of hours now with basically full pre-pssd function and libido. 100% erection, same size as previously pssd but not as long lasting. Only because I'm lying down and tired, standing up during the day it would be impossible. I thought about the girl I used to know and I cried. It's bittersweet. I could feel what I've been missing out on for so long. One weird thing though is the full libido is only there when I think about her. Not a normal libido where seeing an attractive stranger/fantasising about a celebrity or whatever will get you going. I hope all that returns too.

Edit: ketamine use was heavy, 1.5 to 2 grams over 4 or 5 days, to be honest I don't think it has an effect either way, I'm going to stop talking about illegal drug use on here from now on but to be honest I've done a lot of drugs and nothing has permanently affected pssd so I would say it's normally safe.
I still don't think this is a fair trial I mean like you said you're pretty unhealthy now and smoking 30 ciggs a day.. you messed up by mixing a lot of coctail street drugs and grams of ketamine but anyway I hope you realize that a 100% pre PSSD libido and erection and good improvement in orgasm and sensitivity IS A BLOODY SIGNIFICANT IMPROVEMENT. don't be dissapointed if not all areas of the sexual function does not go back to 100%. you can't ask for 100% back while you did abuse drugs and smoke dozens of cigg daily and that could be causing it !If a person who doesn't have PSSD takes estrogen he would loose his morning wood and pretty much would have some negative Impact on all areas of his sexual function that is because estrogen negatively effects sexual function In Men.Same goes for you.Since estrogen is inducing the increase in SERT sensitivity and post synaptic 5ht2a you are getting the PRE PSSD libido and having profound improvement on all areas of your sexual function which you never ever had before only conjectures the Problem related to SERT(Mainly) and other serotonin receptors and overall a lot of serotonin flowing in the brain.

Overall I think this is in line with the PSSD rats study
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