6 week wheel running exercise in rats induces increased expression of 5-HT1A autoreceptors in mice.

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guacamo
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6 week wheel running exercise in rats induces increased expression of 5-HT1A autoreceptors in mice.

Unread post by guacamo »

Name of the topic should be "6 week wheel running exercise in rats induces increased expression of 5-HT1A autoreceptors" if any moderator can delete the "in mice part" it would be great :D
https://pubmed.ncbi.nlm.nih.gov/15737672/
Background: Altered serotonergic (5-HT) neurotransmission is implicated in the antidepressant and anxiolytic properties of physical
activity. In the current study, we investigated whether physical activity alters factors involved in the regulation of central 5-HT neural
activity.
Methods: In situ hybridization was used to quantify levels of 5-HT transporter (5-HTT), 5-HT1A, 5-HT1B, and 1b-adrenergic receptor
(1b ADR) messenger ribonucleic acids (mRNAs) in the dorsal (DRN) and median raphe (MR) nuclei of male Fischer rats after either
sedentary housing or 3 days, 3 weeks, or 6 weeks of wheel running.
Results: Wheel running produced a rapid and lasting reduction of 5-HT1B mRNA in the ventral DRN. Three weeks of wheel running
decreased 5-HTT mRNA in the DRN and MR and increased 1b ADR mRNA in the DRN. After 6 weeks of wheel running, 5-HTT mRNA
remained reduced, but 1b ADR mRNA returned to sedentary levels. Serotonin1A mRNA was increased in the MR and certain DRN
subregions after 6 weeks only
.
Conclusions: Data suggest that the central 5-HT system is sensitive to wheel running in a time-dependent manner. The observed
changes in mRNA regulation in a subset of raphe nuclei might contribute to the stress resistance produced by wheel running and the
antidepressant and anxiolytic effects of physical activity.

Reduction of 5-HT1B receptor was rapid and seen after only 3 days of training, changes in 5-HT1A receptors needed longer and were not present after 3 days or 3 week training, but only after 6 weeks of training.
Dorsal raphe nucleus is where the supposed SSRI pssd-inducing downregulation of 5-HT1A receptor happens. Both reduction in 5-HT1B and increased expression of 5-HT1A autoreceptors should be beneficial for PSSD. Also take in mind that this study stopped at 6 weeks, the fair take would be that these changes in expression are even bigger following longer regimen. 5-HT1B receptor in preoptic area of hypothalamus blocks cAMP induced PKA, which stop exocytosis of glutamate, glutamate release in preoptic area induces copulation in rats, more about it there https://www.nature.com/articles/1301396.

https://imgur.com/F5Yljnk https://imgur.com/a/kYVGUnY https://imgur.com/xB4fcGS images of changes in protein expression in sedentary, 3 days, 3 weeks and 6 weeks trained rats.

I write this post on the fly, but i want to add context from other studies that i forgot to save, when we combine them the conclusion is as follows:
1. The higher heart beat in the training the stronger the changes should be, with interval running inducing the strongest changes.
2. The more consistent training the stronger the changes should be.
3. HIIT and especially Interval running outperforms classical aerobic exercise.
4. This method of increasing 5-HT1A autoreceptor outperforms St John Wort induced increase in 5-HT1A.

Many people on this forum look for supplements or drugs as a method of increasing 5-HT1A autoreceptors so i thought that this post may be helpful for these people.
Last edited by guacamo on Sat Oct 09, 2021 10:04 am, edited 1 time in total.
PsychoGenesis
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Re: 6 week wheel running exercise in rats induces increased expression of 5-HT1A autoreceptors in mice.

Unread post by PsychoGenesis »

yeah, good reminder on this study
the thing that prevents most people doing cardio i believe is really the consistency
sopgirl
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Re: 6 week wheel running exercise in rats induces increased expression of 5-HT1A autoreceptors in mice.

Unread post by sopgirl »

Very interesting. I wonder whether the timescale for upregulation of receptors is the same in human brains...
rladhope1
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Re: 6 week wheel running exercise in rats induces increased expression of 5-HT1A autoreceptors in mice.

Unread post by rladhope1 »

I'll give this a shot by doing daily HIIT on a spin bike.
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