Allopregnenolone & Increased GABA-Receptor Theory of PSSD

This is a place to post research you have done on the topic along with your conclusions.
cdraham
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by cdraham »

Area1255_2021 wrote: Sat Sep 11, 2021 10:30 pm My Nitric Oxide Theory I think still trumps this but its still *interesting* either way.
Lol what do you mean with trumps this? So you're not sure which theory pssd is?
Area1255_2021
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Area1255_2021 »

cdraham wrote: Sun Sep 12, 2021 1:18 pm
Area1255_2021 wrote: Sat Sep 11, 2021 10:30 pm My Nitric Oxide Theory I think still trumps this but its still *interesting* either way.
Lol what do you mean with trumps this? So you're not sure which theory pssd is?
The Nitric Oxide theory applies to all theories/science. PSSD IS a nitric-oxide issue.
cdraham
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by cdraham »

Area1255_2021 wrote: Sun Sep 12, 2021 1:20 pm
cdraham wrote: Sun Sep 12, 2021 1:18 pm
Area1255_2021 wrote: Sat Sep 11, 2021 10:30 pm My Nitric Oxide Theory I think still trumps this but its still *interesting* either way.
Lol what do you mean with trumps this? So you're not sure which theory pssd is?
The Nitric Oxide theory applies to all theories/science. PSSD IS a nitric-oxide issue.
Whats allopregnanolone to do with nitric oxide?
Area1255_2021
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Area1255_2021 »

cdraham wrote: Sun Sep 12, 2021 1:21 pm
Area1255_2021 wrote: Sun Sep 12, 2021 1:20 pm
cdraham wrote: Sun Sep 12, 2021 1:18 pm

Lol what do you mean with trumps this? So you're not sure which theory pssd is?
The Nitric Oxide theory applies to all theories/science. PSSD IS a nitric-oxide issue.
Whats allopregnanolone to do with nitric oxide?
Because nitric oxide regulates Allopregnenolone.
Also it stimulates sex hormones; through Luteinizing Hormone.
cdraham
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by cdraham »

Area1255_2021 wrote: Sun Sep 12, 2021 1:23 pm
cdraham wrote: Sun Sep 12, 2021 1:21 pm
Area1255_2021 wrote: Sun Sep 12, 2021 1:20 pm

The Nitric Oxide theory applies to all theories/science. PSSD IS a nitric-oxide issue.
Whats allopregnanolone to do with nitric oxide?
Because nitric oxide regulates Allopregnenolone.
Also it stimulates sex hormones; through Luteinizing Hormone.
Rodent model of neuropathic pain.. How does this translate to humans
Area1255_2021
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Area1255_2021 »

cdraham wrote: Sun Sep 12, 2021 1:25 pm
Area1255_2021 wrote: Sun Sep 12, 2021 1:23 pm
cdraham wrote: Sun Sep 12, 2021 1:21 pm

Whats allopregnanolone to do with nitric oxide?
Because nitric oxide regulates Allopregnenolone.
Also it stimulates sex hormones; through Luteinizing Hormone.
Rodent model of neuropathic pain.. How does this translate to humans
Its just the mechanics.
cdraham
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by cdraham »

Area1255_2021 wrote: Sun Sep 12, 2021 3:24 pm
cdraham wrote: Sun Sep 12, 2021 1:25 pm
Rodent model of neuropathic pain.. How does this translate to humans
Its just the mechanics.
I don't rly believe this theory. Makes no sense why people get windows on corticosteroids and antibiotics
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Delfador
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Delfador »

ALLO does not raise gaba, alloi is a modulator of gaba receptor. It binds to the gaba receptor at a different site than gaba does. And most receptor modulators have an inverted U shaped curve of their affinity as agonists with concentration. High allo might inhibit gaba. It's a modulator, not an agonist
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