Allopregnenolone & Increased GABA-Receptor Theory of PSSD

This is a place to post research you have done on the topic along with your conclusions.
Area1255_2021
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Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Area1255_2021 »

Hi all! I don't have time to write a whole post right now...
but, I was thinking, some of the dysphoric/anhedonic & yet Anxiolytic/numbing effects might be due to an over-active GABA-system; Post-SSRI.
So I decided to do some research...
Turns out,
SSRI's increase GABA-B receptors & binding: https://pubmed.ncbi.nlm.nih.gov/15451391/
SSRI's increase AlloPregnenolone which raises GABA: https://pubmed.ncbi.nlm.nih.gov/9807641/

GABA has negative effects/impact on sexual function via reduction of hypothalamus activity --> https://pubmed.ncbi.nlm.nih.gov/7623135/
...and Gonadotropins --> https://pubmed.ncbi.nlm.nih.gov/11394636/
and VIA the NeuroSteroids can have "paradoxical" Anhedonic (ANHEDONIA-CAUSING) and dysphoric effects --> https://pubmed.ncbi.nlm.nih.gov/21600269/
...and GABA itself has Dysphoric/Anhedonic effects --> https://pubmed.ncbi.nlm.nih.gov/33620549/
Area1255_2021
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Area1255_2021 »

My Nitric Oxide Theory I think still trumps this but its still *interesting* either way.
Impermanence
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Impermanence »

Area1255_2021 wrote: Sat Sep 11, 2021 10:28 pm Hi all! I don't have time to write a whole post right now...
but, I was thinking, some of the dysphoric/anhedonic & yet Anxiolytic/numbing effects might be due to an over-active GABA-system; Post-SSRI.
So I decided to do some research...
Turns out,
SSRI's increase GABA-B receptors & binding: https://pubmed.ncbi.nlm.nih.gov/15451391/
SSRI's increase AlloPregnenolone which raises GABA: https://pubmed.ncbi.nlm.nih.gov/9807641/

GABA has negative effects/impact on sexual function via reduction of hypothalamus activity --> https://pubmed.ncbi.nlm.nih.gov/7623135/
...and Gonadotropins --> https://pubmed.ncbi.nlm.nih.gov/11394636/
and VIA the NeuroSteroids can have "paradoxical" Anhedonic (ANHEDONIA-CAUSING) and dysphoric effects --> https://pubmed.ncbi.nlm.nih.gov/21600269/
...and GABA itself has Dysphoric/Anhedonic effects --> https://pubmed.ncbi.nlm.nih.gov/33620549/
And over GABA could explain memories issues... Like with Benzo or alcohol...
Interesting.
By the way I like also the nitric oxide theory...
cdraham
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by cdraham »

Area1255_2021 wrote: Sat Sep 11, 2021 10:28 pm Hi all! I don't have time to write a whole post right now...
but, I was thinking, some of the dysphoric/anhedonic & yet Anxiolytic/numbing effects might be due to an over-active GABA-system; Post-SSRI.
So I decided to do some research...
Turns out,
SSRI's increase GABA-B receptors & binding: https://pubmed.ncbi.nlm.nih.gov/15451391/
SSRI's increase AlloPregnenolone which raises GABA: https://pubmed.ncbi.nlm.nih.gov/9807641/

GABA has negative effects/impact on sexual function via reduction of hypothalamus activity --> https://pubmed.ncbi.nlm.nih.gov/7623135/
...and Gonadotropins --> https://pubmed.ncbi.nlm.nih.gov/11394636/
and VIA the NeuroSteroids can have "paradoxical" Anhedonic (ANHEDONIA-CAUSING) and dysphoric effects --> https://pubmed.ncbi.nlm.nih.gov/21600269/
...and GABA itself has Dysphoric/Anhedonic effects --> https://pubmed.ncbi.nlm.nih.gov/33620549/
Yup. Just what raises allopreg? Check my theory. I hypothized this some time ago.

Although it seems intuitive it's not ssris direct effect on 3a HSD that raises allopreg permanently in pssd

I thought we need GAMSAs like golexanolone. But thats not how to solve this.
Area1255_2021
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Joined: Sun Aug 15, 2021 4:45 pm
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Area1255_2021 »

cdraham wrote: Sun Sep 12, 2021 3:50 am
Area1255_2021 wrote: Sat Sep 11, 2021 10:28 pm Hi all! I don't have time to write a whole post right now...
but, I was thinking, some of the dysphoric/anhedonic & yet Anxiolytic/numbing effects might be due to an over-active GABA-system; Post-SSRI.
So I decided to do some research...
Turns out,
SSRI's increase GABA-B receptors & binding: https://pubmed.ncbi.nlm.nih.gov/15451391/
SSRI's increase AlloPregnenolone which raises GABA: https://pubmed.ncbi.nlm.nih.gov/9807641/

GABA has negative effects/impact on sexual function via reduction of hypothalamus activity --> https://pubmed.ncbi.nlm.nih.gov/7623135/
...and Gonadotropins --> https://pubmed.ncbi.nlm.nih.gov/11394636/
and VIA the NeuroSteroids can have "paradoxical" Anhedonic (ANHEDONIA-CAUSING) and dysphoric effects --> https://pubmed.ncbi.nlm.nih.gov/21600269/
...and GABA itself has Dysphoric/Anhedonic effects --> https://pubmed.ncbi.nlm.nih.gov/33620549/
Yup. Just what raises allopreg? Check my theory. I hypothized this some time ago.

Although it seems intuitive it's not ssris direct effect on 3a HSD that raises allopreg permanently in pssd

I thought we need GAMSAs like golexanolone. But thats not how to solve this.
Nope! Nitric Oxide regulates GABA, reduces Serotonin, raises Dopamine - I think that's the way to solve this!
cdraham
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by cdraham »

Many tried viagra or l histidine
Thomas
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Thomas »

Area1255_2021 wrote: Sat Sep 11, 2021 10:28 pm but, I was thinking, some of the dysphoric/anhedonic & yet Anxiolytic/numbing effects might be due to an over-active GABA-system; Post-SSRI.
How would you explain so many insomnias with this theory?
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: low libido | sexual numbness | anhedonia | insomnia
Area1255_2021
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Joined: Sun Aug 15, 2021 4:45 pm
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Area1255_2021 »

Thomas wrote: Sun Sep 12, 2021 10:10 am
Area1255_2021 wrote: Sat Sep 11, 2021 10:28 pm but, I was thinking, some of the dysphoric/anhedonic & yet Anxiolytic/numbing effects might be due to an over-active GABA-system; Post-SSRI.
How would you explain so many insomnias with this theory?
Because GABA inhibits serotonin levels [1].
Thomas
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Thomas »

So, this contradicts your own theory ("excessive serotonergic neurotransmission"), does it?
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: low libido | sexual numbness | anhedonia | insomnia
Area1255_2021
Posts: 42
Joined: Sun Aug 15, 2021 4:45 pm
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Re: Allopregnenolone & Increased GABA-Receptor Theory of PSSD

Unread post by Area1255_2021 »

Thomas wrote: Sun Sep 12, 2021 11:31 am So, this contradicts your own theory ("excessive serotonergic neurotransmission"), does it?
Not exactly...because GABA can inhibit serotonergic activity in the Emotional areas of the Brain, yet have no effect/dull effect on the PVN.
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