Allopregnanolones biphasic action at the GABAa receptor

This is a place to post research you have done on the topic along with your conclusions.
cdraham
Posts: 448
Joined: Thu Jul 04, 2019 10:39 am
Contact:

Allopregnanolones biphasic action at the GABAa receptor

Unread post by cdraham »

https://epiphanyasd.blogspot.com/2015/0 ... ly-or.html
Conclusion

It would seem that, depending on your own natural level of allopregnanolone, supplementing it with pregnenolone or progesterone could have very different effects, depending on the dosage.
In addition, we have the fact that in autism the GABAA receptor is dysfunctional and some aspects may work in reverse.

Having established that very large doses of Pregnenolone (which produces allopregnanolone) seems to be helpful in autism and schizophrenia, it would be well worth measuring the level of allopregnanolone, produced by different doses and of course investigating the effect of tiny doses of Pregnenolone.

Anecdotally, in typical people, tiny doses of Pregnenolone do have an effect.

It might turn out that because of where you are actually on the curve, you might actually need a low dose Negative Allosteric Modulator (NAM), to make you move to the left. Interestingly there is such a NAM, Pregnenolone Sulfate.
Post Reply

Who is online

Users browsing this forum: No registered users and 6 guests