Conclusion
It would seem that, depending on your own natural level of allopregnanolone, supplementing it with pregnenolone or progesterone could have very different effects, depending on the dosage.
In addition, we have the fact that in autism the GABAA receptor is dysfunctional and some aspects may work in reverse.
Having established that very large doses of Pregnenolone (which produces allopregnanolone) seems to be helpful in autism and schizophrenia, it would be well worth measuring the level of allopregnanolone, produced by different doses and of course investigating the effect of tiny doses of Pregnenolone.
Anecdotally, in typical people, tiny doses of Pregnenolone do have an effect.
It might turn out that because of where you are actually on the curve, you might actually need a low dose Negative Allosteric Modulator (NAM), to make you move to the left. Interestingly there is such a NAM, Pregnenolone Sulfate.
Allopregnanolones biphasic action at the GABAa receptor
Allopregnanolones biphasic action at the GABAa receptor
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