PSSD can be triggered by mitochondrial instability

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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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JP1985 wrote: Thu Jun 18, 2020 4:53 pm Sorry I’m confused now. Should I leave PQQ out? Maybe it’s the other things making me feel happier? What happens mixing niacinamide with pqq? I was hoping to get that connection feeling that you mentioned that’s why I started the pqq. Ps I forgot about lecithin in my last post, I’m also taking that too 👍
In 2017 I was thinking about pqq in context of nerve growth factor, wanted to boost it. I took 1 bottle in a row. The improvement happened but I don't have a proof that it's exactly pqq, bacause I was also drinking cayenne pepper for a month before it. I bought another bottle next month, but there was no further improvements. However it improves mood, that's I'm sure of.
PQQ increases mitochondria fusion (simply saying size). On the other hand if serious inflammation/oxidative stress happens in the body it is more wise to utilise mitochondrias with the most damage from oxidative stress. This is done through mitochondrial fission (cutting). Niacinamide helps with that. So it makes sense to reduce the number of damaged units in the body first.
The guy whose posts on longecity forum I posted a link to offers a scheme where you take profission supplements for a few days, than take profusion ones (like pqq) to improve your body safely and with optimal speed. He clearly researched on the topic a lot and for many years.
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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And from the stack many things make you happier, a lot of studies link to that. Just put fish oil or carnitine or nad+ with depression in google.
Luke20
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Re: PSSD can be triggered by mitochondrial instability

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JP1985 wrote: Fri Jun 05, 2020 4:26 pm
kpavel wrote: Mon May 11, 2020 3:27 am
cdraham wrote: Sun May 10, 2020 6:32 pm Very interesting indeed, may I ask what your symptoms before were? How was your reaction to alcohol, recreational drugs?

What exactly did you do to help your mitochondria? Do you feel 100% cured of your PSSD now?

btw: the member helvy improved on HBOT initially before his crash, that might have boosted mitochondria function

I did some research and came across 10 pass ozone therapy, something I might try.
Yes, really, I feel like a cured man, it was something very notable happening and things are still improving. First of all it is a feeling that obstacles in life is not something to worry about. I stopped doubting a lot, sort of an alpha-male (yes, I can, it's not difficult) feeling inside (so it's only partly about testosterone, more about dopamine). Also you know, when you suspect a heart condition life becomes very miserable. Now I can do things till 1 am every day if I want.

Another symptom is I began sweating normal and I'm less restless. I had very little sweat, my sleep was intermittent, I didn't feel a pleasure to sleep a little more. Also my hands were in increased tonus/tension state, especially veins were very prominent on them several times in a day. When I walked my heart rate was more than 100 bpm, and when I stopped it didn't calm for a long time, so called intolerance to exercise, I guess. So this all was a lot of discomfort, stopping any pleasure in life. Also I can read texts on screen and not return to repeat, like I did in the worst times, but see the whole picture from page.

Interesting fact, I began playing computer games a lot, it's not a meh now. I feel it is easier to become an addict now). I drink coffee more than ever. Watching dreams every night 8-) , they are colorful, sometimes erotic, I can be almost woken up and continue dreaming if you understand what it feels like. My morning erections are everyday. I also noticed my balls have grown. Strange coincidence. Also my laughing is more spontaneous and natural.

I don't use drugs, it's not legal here and really dangerous. Not worth it. I react to wine well, increased mood, even more than from caffeine-containing drinks.

I combine several supplements everyday, but believe the most useful were niacinamide, d-ribose, lecithin, resveratrol and carnitine. Probably PQQ, but not now, 2 years ago my connecton feeling from brain to penis was restored while taking pqq.

Oxygen/ozone can be helpful for mitochondrias but obviously in the right concentration.
https://www.ncbi.nlm.nih.gov/pubmed/25828268
https://www.ncbi.nlm.nih.gov/pubmed/31827546
https://www.ncbi.nlm.nih.gov/pubmed/25701186
https://www.ncbi.nlm.nih.gov/pubmed/29022413
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
https://www.cell.com/cell/fulltext/S009 ... 13)01521-3
Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but its causes are debated. We show that, during aging, there is a specific loss of mitochondrial, but not nuclear, encoded OXPHOS subunits. We trace the cause to an alternate PGC-1α/β-independent pathway of nuclear-mitochondrial communication that is induced by a decline in nuclear NAD+ and the accumulation of HIF-1α under normoxic conditions, with parallels to Warburg reprogramming. Deleting SIRT1 accelerates this process, whereas raising NAD+ levels in old mice restores mitochondrial function to that of a young mouse in a SIRT1-dependent manner. Thus, a pseudohypoxic state that disrupts PGC-1α/β-independent nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age, a process that is apparently reversible.
Hello mate, I like the sound of this but just decided to start taking St Johns Wort.. Do you think I could add the supplements you took to it? Or would any of them cause me problems mixing them? Mostly wanting to improve penis sensation, feelings of pleasure and energy levels would be great, Thanks JP
Hi bro it's luke I did send you a private messege, I'm just trying to figure out how to use this forum lol. I came across this post of yours and I have very similar symptoms that you used to have. I don't sweat anymore, my heart rate does not regulate (exactly the same as when you said about walking and then sitting down but heart takes ages to regulate), sleep is awful 1-2 hours a night at most. My PSSD is severe was caused by citalopram. Do you rekon I could have a mitochondrial issue? I do have some PQQ or should I try niacinamide first and a few other compounds you mentioned? Would be forever grateful if you could give me some advice
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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Luke20 wrote: Fri Aug 21, 2020 5:33 am Hi bro it's luke I did send you a private messege, I'm just trying to figure out how to use this forum lol. I came across this post of yours and I have very similar symptoms that you used to have. I don't sweat anymore, my heart rate does not regulate (exactly the same as when you said about walking and then sitting down but heart takes ages to regulate), sleep is awful 1-2 hours a night at most. My PSSD is severe was caused by citalopram. Do you rekon I could have a mitochondrial issue? I do have some PQQ or should I try niacinamide first and a few other compounds you mentioned? Would be forever grateful if you could give me some advice
Definitely niacinamide. Your sleep is bad man...
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Re: PSSD can be triggered by mitochondrial instability

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Do you think I have a mitochondrial issue of some sort could this be effecting my sleep? I have some niacinamide will this help? I also have pqq is this worth a go after niacinamide bro? Which issues did this help you with? Thanks
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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Possbile, because classical pellagra symptoms include insomnia and cardiomyopathy. Also tachycardia may be a protective adaptation, which leads to cardiomyopathy with time.
https://en.wikipedia.org/wiki/Pellagra# ... d_symptoms
https://pubmed.ncbi.nlm.nih.gov/28449778/
I would try it. https://www.nature.com/articles/s41598-019-53648-7 (niacin worked for sleep here, not niacinamide)
PQQ is ok too.

You can add rhodiola rosea extract since it increases NAMPT, a critical enzyme in converting niacinamide into NAD+
https://pubmed.ncbi.nlm.nih.gov/28714019/
fellow1
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Re: PSSD can be triggered by mitochondrial instability

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kpavel wrote: Fri Jun 19, 2020 1:47 am
The guy whose posts on longecity forum I posted a link to offers a scheme where you take profission supplements for a few days
Examples of profission supplements plz ? except niacinamide. Makes me feel pretty bad.
Luke20
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Re: PSSD can be triggered by mitochondrial instability

Unread post by Luke20 »

kpavel wrote: Mon May 11, 2020 3:27 am
cdraham wrote: Sun May 10, 2020 6:32 pm Very interesting indeed, may I ask what your symptoms before were? How was your reaction to alcohol, recreational drugs?

What exactly did you do to help your mitochondria? Do you feel 100% cured of your PSSD now?

btw: the member helvy improved on HBOT initially before his crash, that might have boosted mitochondria function

I did some research and came across 10 pass ozone therapy, something I might try.
Yes, really, I feel like a cured man, it was something very notable happening and things are still improving. First of all it is a feeling that obstacles in life is not something to worry about. I stopped doubting a lot, sort of an alpha-male (yes, I can, it's not difficult) feeling inside (so it's only partly about testosterone, more about dopamine). Also you know, when you suspect a heart condition life becomes very miserable. Now I can do things till 1 am every day if I want.

Another symptom is I began sweating normal and I'm less restless. I had very little sweat, my sleep was intermittent, I didn't feel a pleasure to sleep a little more. Also my hands were in increased tonus/tension state, especially veins were very prominent on them several times in a day. When I walked my heart rate was more than 100 bpm, and when I stopped it didn't calm for a long time, so called intolerance to exercise, I guess. So this all was a lot of discomfort, stopping any pleasure in life. Also I can read texts on screen and not return to repeat, like I did in the worst times, but see the whole picture from page.

Interesting fact, I began playing computer games a lot, it's not a meh now. I feel it is easier to become an addict now). I drink coffee more than ever. Watching dreams every night 8-) , they are colorful, sometimes erotic, I can be almost woken up and continue dreaming if you understand what it feels like. My morning erections are everyday. I also noticed my balls have grown. Strange coincidence. Also my laughing is more spontaneous and natural.

I don't use drugs, it's not legal here and really dangerous. Not worth it. I react to wine well, increased mood, even more than from caffeine-containing drinks.

I combine several supplements everyday, but believe the most useful were niacinamide, d-ribose, lecithin, resveratrol and carnitine. Probably PQQ, but not now, 2 years ago my connecton feeling from brain to penis was restored while taking pqq.

Oxygen/ozone can be helpful for mitochondrias but obviously in the right concentration.
https://www.ncbi.nlm.nih.gov/pubmed/25828268
https://www.ncbi.nlm.nih.gov/pubmed/31827546
https://www.ncbi.nlm.nih.gov/pubmed/25701186
https://www.ncbi.nlm.nih.gov/pubmed/29022413
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
https://www.cell.com/cell/fulltext/S009 ... 13)01521-3
Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but its causes are debated. We show that, during aging, there is a specific loss of mitochondrial, but not nuclear, encoded OXPHOS subunits. We trace the cause to an alternate PGC-1α/β-independent pathway of nuclear-mitochondrial communication that is induced by a decline in nuclear NAD+ and the accumulation of HIF-1α under normoxic conditions, with parallels to Warburg reprogramming. Deleting SIRT1 accelerates this process, whereas raising NAD+ levels in old mice restores mitochondrial function to that of a young mouse in a SIRT1-dependent manner. Thus, a pseudohypoxic state that disrupts PGC-1α/β-independent nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age, a process that is apparently reversible.
Hey buddy Iv just read this post and I'm pretty sure I could have a mitochondrial issue too. My heart does not regulate just like you mentioned go for a walk and then sit down and it takes ages to calm down (been to hospital twice recently because I suspected heart condition but was all clear) . I'm very restless, sleep is awful and I don't sweat atall. I have pqq and niacinamide.. Could you please give me some advice I'm in a very desperate situation? Thankyou
Luke20
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Re: PSSD can be triggered by mitochondrial instability

Unread post by Luke20 »

kpavel wrote: Fri Aug 21, 2020 3:01 pm Possbile, because classical pellagra symptoms include insomnia and cardiomyopathy. Also tachycardia may be a protective adaptation, which leads to cardiomyopathy with time.
https://en.wikipedia.org/wiki/Pellagra# ... d_symptoms
https://pubmed.ncbi.nlm.nih.gov/28449778/
I would try it. https://www.nature.com/articles/s41598-019-53648-7 (niacin worked for sleep here, not niacinamide)
PQQ is ok too.

You can add rhodiola rosea extract since it increases NAMPT, a critical enzyme in converting niacinamide into NAD+
https://pubmed.ncbi.nlm.nih.gov/28714019/

OK cool what is the best thing I can do to boost my mitochondrial function over the next few months? If I do this do you think it could help reverse the symptoms I'm having (insomnia, fast heart rate, no sweat? I have 500mg niacinamide would you suggest taking that once a day? And is PQQ safe with niacinamide or would you not take both together?
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

Unread post by kpavel »

fellow1 wrote: Sat Aug 22, 2020 12:09 am
kpavel wrote: Fri Jun 19, 2020 1:47 am
The guy whose posts on longecity forum I posted a link to offers a scheme where you take profission supplements for a few days
Examples of profission supplements plz ? except niacinamide. Makes me feel pretty bad.
I did some search yesterday, now I'm not sure if this model is not too simplistic. B3 is obviously essential. What dose did you take, when and for how long? Anyway I found that things that increase DRP1 can be good and bad, depends on balance, but generally increased fission is described in context of diseases like diabetes of cardiovascular ones. Palmitic fatty acid can increase fission and cause insulin resistance. Niacinamide is sometimes mentioned in this context, but I think it is nowhere as dangerous as excess fat. Norepinephrine too. Stearic fatty acid boosts fusion. OPA1 (fusion) was dramatically low in one study of heart failure model of mice or human. https://pubmed.ncbi.nlm.nih.gov/19493956/ https://pubmed.ncbi.nlm.nih.gov/26785494/ So knowing SSRI, or mdma, or fenfluramine are all somewhere around heart failure research (or pulmonary hypertension) issues we can specualte in this key. Generally you can experiment with other forms of the vitamin, lower dose, or experiment with a plant/nutrient boosting opa1 or mfn1/mfn2.
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