PSSD can be triggered by mitochondrial instability

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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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Luke20 wrote: Sun Aug 23, 2020 8:50 am
kpavel wrote: Fri Aug 21, 2020 3:01 pm Possbile, because classical pellagra symptoms include insomnia and cardiomyopathy. Also tachycardia may be a protective adaptation, which leads to cardiomyopathy with time.
https://en.wikipedia.org/wiki/Pellagra# ... d_symptoms
https://pubmed.ncbi.nlm.nih.gov/28449778/
I would try it. https://www.nature.com/articles/s41598-019-53648-7 (niacin worked for sleep here, not niacinamide)
PQQ is ok too.

You can add rhodiola rosea extract since it increases NAMPT, a critical enzyme in converting niacinamide into NAD+
https://pubmed.ncbi.nlm.nih.gov/28714019/

OK cool what is the best thing I can do to boost my mitochondrial function over the next few months? If I do this do you think it could help reverse the symptoms I'm having (insomnia, fast heart rate, no sweat? I have 500mg niacinamide would you suggest taking that once a day? And is PQQ safe with niacinamide or would you not take both together?
I took pqq sparingly and didn't mix it with vit. b3. Niacinamide (like nicorandil or minoxidil) can open potassium channels, so this could help with sweat in me. Take it with d-ribose (500-1000 mg + 2-3 g of ribose - this helps to enhance the effect). It will help with restlessness too. Depending on you budget add l-lysine, lecithin in granules, l-carnitine in powder, omega 3 (in form of high epa and dha capsules, of fish oil, or fresh darkbottle flaxseed oil), vitamin c and vitamin e. Don't ever feed yourself in junk food, grains rubbish style. Better consume legumes (I prefer lentils), meat, vegs, fruit, nuts, mushrooms, berries. You will be ok in a few months. If you can, monitor your condition with a help of a good doctor. Such things are serious and that luck of sleep obvously dangerous. As I have written above, you can add niacin, since it can be useful to help sleeping. Several herbs, or as I posted in insomnia thread (wheat germ) help to sleep better and this isn't all of course (https://www.earthclinic.com/cures/insomnia.html exclude 5-htp from that list of remedies).
Luke20
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Re: PSSD can be triggered by mitochondrial instability

Unread post by Luke20 »

kpavel wrote: Sun Aug 23, 2020 11:54 am
Luke20 wrote: Sun Aug 23, 2020 8:50 am
kpavel wrote: Fri Aug 21, 2020 3:01 pm Possbile, because classical pellagra symptoms include insomnia and cardiomyopathy. Also tachycardia may be a protective adaptation, which leads to cardiomyopathy with time.
https://en.wikipedia.org/wiki/Pellagra# ... d_symptoms
https://pubmed.ncbi.nlm.nih.gov/28449778/
I would try it. https://www.nature.com/articles/s41598-019-53648-7 (niacin worked for sleep here, not niacinamide)
PQQ is ok too.

You can add rhodiola rosea extract since it increases NAMPT, a critical enzyme in converting niacinamide into NAD+
https://pubmed.ncbi.nlm.nih.gov/28714019/

OK cool what is the best thing I can do to boost my mitochondrial function over the next few months? If I do this do you think it could help reverse the symptoms I'm having (insomnia, fast heart rate, no sweat? I have 500mg niacinamide would you suggest taking that once a day? And is PQQ safe with niacinamide or would you not take both together?
I took pqq sparingly and didn't mix it with vit. b3. Niacinamide (like nicorandil or minoxidil) can open potassium channels, so this could help with sweat in me. Take it with d-ribose (500-1000 mg + 2-3 g of ribose - this helps to enhance the effect). It will help with restlessness too. Depending on you budget add l-lysine, lecithin in granules, l-carnitine in powder, omega 3 (in form of high epa and dha capsules, of fish oil, or fresh darkbottle flaxseed oil), vitamin c and vitamin e. Don't ever feed yourself in junk food, grains rubbish style. Better consume legumes (I prefer lentils), meat, vegs, fruit, nuts, mushrooms, berries. You will be ok in a few months. If you can monitor your condition with a help of a good doctor. Such things are serious and that luck of sleep obvously dangerous.
Thankyou! So all the things you have mentioned above are they just to help with mitochondrial issues? I haven't been diagnosed with a mito issue docs pretty much laughed at me when I mentioned it. It's just I have similar symptoms to what you had before.
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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Yeah. Docs see illnesses in different key. But put in google 'mitochondrial' and an ailment, you will see.

Also, don't forget, most doctors rarely prescribe natural stuff. Even go against it sometimes despite of longterm practice decades before.

If arrhythmia/palpitations are suspected see this https://www.lifeextension.com/protocols ... rrhythmias - they have good lists and explanations, you can show that to your doctor, he would be more serious.

https://www.lifeextension.com/protocols ... Treatments
Luke20
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Re: PSSD can be triggered by mitochondrial instability

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OK cool. Did you actually get diagnosed with a mitochondrial issue? And I take it we can reverse the mito problem? Because obviously inheritance of mitochondrial disease normally kills people within 1-3 years that's what I read anyway? iv been taking niacinamide for the last 2 days and that has really calmed my heart down and restlessness! Did this regeim help some of your pssd symptoms too buddy? Thanks
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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Luke20 wrote: Sun Aug 23, 2020 1:05 pm OK cool. Did you actually get diagnosed with a mitochondrial issue? And I take it we can reverse the mito problem? Because obviously inheritance of mitochondrial disease normally kills people within 1-3 years that's what I read anyway? iv been taking niacinamide for the last 2 days and that has really calmed my heart down and restlessness! Did this regeim help some of your pssd symptoms too buddy? Thanks
That helped significantly several symptoms, especially anhedonia and DE, confidence in getting erection.

Rare genetic mutations aren't the only way to harm mitochondrias, many chemicals do this, they are our body structures with same vulnerability to poisons and deficiencies as our skin.
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Re: PSSD can be triggered by mitochondrial instability

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kpavel wrote: Sun Aug 23, 2020 1:24 pm
Luke20 wrote: Sun Aug 23, 2020 1:05 pm OK cool. Did you actually get diagnosed with a mitochondrial issue? And I take it we can reverse the mito problem? Because obviously inheritance of mitochondrial disease normally kills people within 1-3 years that's what I read anyway? iv been taking niacinamide for the last 2 days and that has really calmed my heart down and restlessness! Did this regeim help some of your pssd symptoms too buddy? Thanks
That helped significantly several symptoms, especially anhedonia and DE, confidence in getting erection.

Rare genetic mutations aren't the only way to harm mitochondrias, many chemicals do this, they are our body structures with same vulnerability to poisons and deficiencies as our skin.
That's good to hear and I'm glad it has really helped you! So if it's chemically induced do you think it's reversible as in restoring healthy function? As the people that have the rare genetic condition aparently cannot cure it?
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

Unread post by kpavel »

Luke20 wrote: Sun Aug 23, 2020 1:38 pm
kpavel wrote: Sun Aug 23, 2020 1:24 pm
Luke20 wrote: Sun Aug 23, 2020 1:05 pm OK cool. Did you actually get diagnosed with a mitochondrial issue? And I take it we can reverse the mito problem? Because obviously inheritance of mitochondrial disease normally kills people within 1-3 years that's what I read anyway? iv been taking niacinamide for the last 2 days and that has really calmed my heart down and restlessness! Did this regeim help some of your pssd symptoms too buddy? Thanks
That helped significantly several symptoms, especially anhedonia and DE, confidence in getting erection.

Rare genetic mutations aren't the only way to harm mitochondrias, many chemicals do this, they are our body structures with same vulnerability to poisons and deficiencies as our skin.
That's good to hear and I'm glad it has really helped you! So if it's chemically induced do you think it's reversible as in restoring healthy function? As the people that have the rare genetic condition aparently cannot cure it?
Thank you! Probably some people with rare genetic disorders can alleviate their symptoms, but they have them from birth and this may have its own impact. Advanced tecnologies and new research will help them with time. But for most people on AD restoration of their function is common, same happens in pssd. Take for example autism. It was incurable initially, but with serious public attention some things were discovered.
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Re: PSSD can be triggered by mitochondrial instability

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Good explanation! What does AD stand for?
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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Luke20 wrote: Mon Aug 24, 2020 5:50 am Good explanation! What does AD stand for?
Antidepressants
CN9
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Re: PSSD can be triggered by mitochondrial instability

Unread post by CN9 »

which niacinamid did you take? nicorandil?
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