You need to look into potentiating long-term potentiation (LTP) more. Your next step should be to restore HPA axis reactivity by downregulating GR. Licorice or a corticosteroid would do that, in theory.DrugsAreBad wrote: @Mesolimbo: Any idea for how long the regimen should be kept up? And why, so far, positive effects have not been permanent?
AnhedonicApe - Intro
Re: AnhedonicApe - Intro
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Re: AnhedonicApe - Intro
Psilocybin combined with licorice then. Let's say psilocybin every 3 days at barely perceptible doses and a teaspoon of licorice root power a day for a few weeks. Sounds reasonable?Mesolimbo wrote:You need to look into potentiating long-term potentiation (LTP) more. Your next step should be to restore HPA axis reactivity by downregulating GR. Licorice or a corticosteroid would do that, in theory.DrugsAreBad wrote: @Mesolimbo: Any idea for how long the regimen should be kept up? And why, so far, positive effects have not been permanent?
Re: AnhedonicApe - Intro
Yes, until you feel potent cortisol effect from the licorice. Then slowly withdraw from it. It has to be slow to prevent rebound upregulation of GR. Also, keep in mind that licorice is a phytoestrogen, so don't dose high.DrugsAreBad wrote: Psilocybin combined with licorice then. Let's say psilocybin every 3 days at barely perceptible doses and a teaspoon of licorice root power a day for a few weeks. Sounds reasonable?
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What does a potent cortisol effect feel like? Licorice seems to have a mild anxiolytic effect that lasts a few hours. I don't know if that's the effect or if it's indicative of an appropriate dose.Mesolimbo wrote:Yes, until you feel potent cortisol effect from the licorice. Then slowly withdraw from it. It has to be slow to prevent rebound upregulation of GR. Also, keep in mind that licorice is a phytoestrogen, so don't dose high.DrugsAreBad wrote: Psilocybin combined with licorice then. Let's say psilocybin every 3 days at barely perceptible doses and a teaspoon of licorice root power a day for a few weeks. Sounds reasonable?
Re: AnhedonicApe - Intro
An energy boost with either hypomania or mild depression. Increased aggression or irritability.DrugsAreBad wrote:What does a potent cortisol effect feel like? Licorice seems to have a mild anxiolytic effect that lasts a few hours. I don't know if that's the effect or if it's indicative of an appropriate dose.Mesolimbo wrote:Yes, until you feel potent cortisol effect from the licorice. Then slowly withdraw from it. It has to be slow to prevent rebound upregulation of GR. Also, keep in mind that licorice is a phytoestrogen, so don't dose high.DrugsAreBad wrote: Psilocybin combined with licorice then. Let's say psilocybin every 3 days at barely perceptible doses and a teaspoon of licorice root power a day for a few weeks. Sounds reasonable?
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@AnhedonicApe Have you tried Saint John's Wort before?
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Mesolimbo wrote:@AnhedonicApe Have you tried Saint John's Wort before?
Not yet, was a little scared to try. I will start the sarcosine first, after that probably the baclofen to test the 5ht theory.
Re: AnhedonicApe - Intro
Keep in mind that SJW raises both GABA and glutamate, albeit mildly. Maybe it would be helpful as a last-stand option.AnhedonicApe wrote:Mesolimbo wrote:@AnhedonicApe Have you tried Saint John's Wort before?
Not yet, was a little scared to try. I will start the sarcosine first, after that probably the baclofen to test the 5ht theory.
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allright i will rememberMesolimbo wrote:Keep in mind that SJW raises both GABA and glutamate, albeit mildly. Maybe it would be helpful as a last-stand option.AnhedonicApe wrote:Mesolimbo wrote:@AnhedonicApe Have you tried Saint John's Wort before?
Not yet, was a little scared to try. I will start the sarcosine first, after that probably the baclofen to test the 5ht theory.
Re: AnhedonicApe - Intro
@Mesolimbo, can you help me too?
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