PAPSD (Post Anti-Psychotic Sexual Dysfunction) - Sonny OP

Any other sexual dysfunctions not properly addressed by medical science.
6-Eggs!
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Re: PAPSD (Post Anti-Psychotic Sexual Dysfunction) - Sonny OP

Unread post by 6-Eggs! »

Just went through my cupboards and drawers and found some of my old medication.

About 2014 I got debilitating CFS and depression and lost my sexual function and libido.

I had been on about 15 different SSRIs, NRIs and SNRIs but I only found 2 old boxes plus one name I recall.

Citalopram
Lovan
Reboxetine.

+ about 10 other SSRIs/SNRIs. All of them made me very unwell so other drug classes were tested as it was apparent that SSRI/SNRIs were intolerable for me. So far no PSSD though.

I was on a new AD that targeted the melatonin system, like placebo. Did nothing being months on them. Valdoxan it was called.

Eventually I opted for moclobemide which worked semi effective but was by far the best. My sexual function returned mostly normal despite still suffering from treatment resistant MDD.

My psych tried a number of mood stabilizers, anti seizure drugs like sodium valporate. Nothing. Placebo.

Then came the antipsychotics. I found an old box of Latuda. I was on that for over a year. Nothing. Placebo.

Then another one or 2 APs, again, nothing. So far nothing after the SSRIs had side effects and only the moclobemide was semi effective and had no side effects.

Then I was put on Rexulti, I saw improvements but then after 18 months on it I got delayed side effects (tardive) including bad sexual dysfunction.

Thinking it was something else as I had not heard of delayed onset side effects. I quite the Rexulti a year later and ended up with severe neurological dysfunction including PSSD like symptoms, Numbness, flaccid glans syndrome, pain etc. Also body wide numbness/burning and movement and function issues as well and odd mental abnormalities that come and go but change all the time.

What I don't understand is all these drugs including the SSRIs (although SSRIs made me sick, side effects always went away after a week on withdrawal) did nothing on withdrawal and didn't cause any long term effects.

Latuda a SGA, similar target profile to Rexulti but not quite the same had such enormously different results, why is what I am trying to understand? Only major difference I can see is Rexulti lists SERT as a target and is very strong occupancy for 5ht-1A, but PET scan studies found Rexulti to be less than 5% occupancy at the higher 4mg dose for both SERT and 5ht-1a. Also the SERT occupancy listed on Wiki which is the only place I even found a SERT listing, displayed it in non standard units and I can't find a way to convert it to the relative Ki (nM) metric.

I was on 2mg so going by that it should be like the study says, negligible occupancy at those 2 sites? Could it be the reasonably strong blockage of 5-ht2a, 2b as well as 7? There is pretty strong partial agonist for D2 and D3 but most of the dopamine withdrawal symptoms went relatively quick and didn't persist like the sensory/sexual issues.
kaimbre
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Re: PAPSD (Post Anti-Psychotic Sexual Dysfunction) - Sonny OP

Unread post by kaimbre »

Ghost wrote: Thu May 18, 2017 6:48 pm Posted by Hades OP
Moved here for clarity purpose
Thu May 18, 2017 4:35 pm


hi all.anyone can tell anything about pasd?i have all the symtoms from pssd,but i used antipsycotics and someone told me that i have pasd?is there any difference?it looks like the same thing to me.or wrost
I have PAPSD from risperidone. I realized that I only get better when I reduce serotonin. Mushrooms and cyproheptadine worked miracles on me. People who have recovered from PSSD have used steroids, herbs like SJW and Inositol, Wellbutrin, and lithium. None of this helped me.

I'm sure MDMA would cure me. But I don't have access to that.
PSSD by a combination of Risperidon and Fluoxetin

Tests: damiana, gingko biloba, cabergolin, pramipexol, buspiron, SJW
Significant improvement only with SJW
Titeuf
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Re: PAPSD (Post Anti-Psychotic Sexual Dysfunction) - Sonny OP

Unread post by Titeuf »

kaimbre wrote: Mon May 27, 2024 12:36 pm
Ghost wrote: Thu May 18, 2017 6:48 pm Posted by Hades OP
Moved here for clarity purpose
Thu May 18, 2017 4:35 pm


hi all.anyone can tell anything about pasd?i have all the symtoms from pssd,but i used antipsycotics and someone told me that i have pasd?is there any difference?it looks like the same thing to me.or wrost
I have PAPSD from risperidone. I realized that I only get better when I reduce serotonin. Mushrooms and cyproheptadine worked miracles on me. People who have recovered from PSSD have used steroids, herbs like SJW and Inositol, Wellbutrin, and lithium. None of this helped me.

I'm sure MDMA would cure me. But I don't have access to that.
Did you know that certain antipsychotics alter 5 alpha-reductase like SSRIs do?

I don't think there is any difference between PSSD and PAPSD?
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