Quetiapine and Premature Ejaculation

Any other sexual dysfunctions not properly addressed by medical science.
SeroquelTroubles
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Quetiapine and Premature Ejaculation

Unread post by SeroquelTroubles »

I noticed a major issue arising with premature ejaculation since I was started on quetiapine XR (Seroquel) mono therapy 300mg/day 5 years ago for bipolar disorder. My psychiatrist added 100mg sertraline, which definitely helped the PE, but caused minor ED. I was switched to escitalopram 20mg in 2020, but since January 2021, I tapered off the escitalopram. I noticed definite improvement in ED, but worse PE again. I am now medication free after tapering the quetiapine XR and some improvement in PE. Has anyone else experienced issues with PE while on Seroquel? Could this be due to an increase in prolactin even though the medication is supposed to be PRL-sparing? I feel much better off the medication and am glad I stopped. I am considering using 100mg 5-HTP for both mood and residual PE. I think the Seroquel was a major cause of my PE. Any thoughts? For PE I am using topical lidocaine these days instead of any pharmacological treatments.
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