PSSD could be small fiber polyneuropathy
Re: PSSD could be small fiber polyneuropathy
Small fiber polyneuropathy we can see as the same symptom than to indicate that it is the name of our symptoms. And there are hundreds of reasons of it.
Re: PSSD could be small fiber polyneuropathy
I was also thinking about this possibility.
Recently I have read about a new study
Agmatine helps with small Fiber neuropathy
Has anyone Made good experience with Agmatine?
Recently I have read about a new study
Agmatine helps with small Fiber neuropathy
Has anyone Made good experience with Agmatine?
Re: PSSD could be small fiber polyneuropathy
Agmatine (as G- Agmatine®) Effectiveness in Painful Small Fiber Neuropathy | Healthcare Dive
Re: PSSD could be small fiber polyneuropathy
Agmatine is used to alleviate pain. This would not help regenerate any fibers and hence would not improve symptoms of sexual dysfunction.
I really wish people would take the SFP idea more seriously and get the testing done instead of messing around with supplements or pharmaceuticals that target neurotransmitters and receptors.
I really wish people would take the SFP idea more seriously and get the testing done instead of messing around with supplements or pharmaceuticals that target neurotransmitters and receptors.
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Re: PSSD could be small fiber polyneuropathy
As far as I know this is not correct. Pain is the most common symptom, regardless whether the neuropathy presents itself length dependent or not.Not the most common symptom at all. With non-length dependent small fiber neuropathy, most common symptom is brain fog, as far as I’ve been told.
Generally the problem of your hypothesis is it's narrow focus on autonomic symptoms. While it's true that SFN can present as a pure autonomic neuropathy, usually sensory symptoms are present as well in such cases. You should also take into account that SFN is not the only cause of autonomic dysfunction and there are also several other symptoms of autonomic dysfunction in SFN that were not reported in PSSD.
The problem here is that it's very hard to get testing done for SFN. I likely had SFN for the last 10 years (no relationship with my mild to moderate PSSD) and I have only been able to get an appointment for testing in the next few days. I have been denied by 3 other clinics, because knowledge on SFN is not very widespread, although it's probably very common. You should also take into account that if doctors do not see an indication for skin biopsy, then you won't get it or you have to pay for it yourself and that's likely the case, when people tell the doctor, that their symptoms were caused by SSRIs.I really wish people would take the SFP idea more seriously and get the testing done instead of messing around with supplements or pharmaceuticals that target neurotransmitters and receptors.
However your idea might have some merit. I remember that one study reported abnormal nerve potentials in post-finasteride syndrome. On the other hand, this does not necessarily mean that the nerves are broken, because abnormal function does not necessarily require outright damage to the nerve. For example sodium channel mutations can sometimes cause severe symptoms in the presence of normal skin biopsy results.
But overall I think it might not be a bad idea as a research project to conduct skin biopsies on patients with PSSD, because if small fiber neuropathy was confirmed, then patients with PSSD could benefit from upcoming treatments. A possible treatment would be Pirenzepine, which has been shown to increase nerve fiber density and is currently trialed by the startup WinSanTor as a disease modifying treatment for small fiber neuropathy. Some people on the internet tried this already and those who responded reported improvements in both sensory and/or autonomic symptoms.
Last edited by NoMansLand on Sun Jan 09, 2022 3:00 pm, edited 1 time in total.
Re: PSSD could be small fiber polyneuropathy
Sorry nur how will you Target receptors without pharmaceuticals
Re: PSSD could be small fiber polyneuropathy
I recommend reaching out to one of the physicians listed here if you are in the United States: https://neuropathycommons.org/experts-directory/usThe problem here is that it's very hard to get testing done for SFN. I likely had SFN for the last 10 years (no relationship with my mild to moderate PSSD) and I have only been able to get an appointment for testing in the next few days. I have been denied by 3 other clinics, because knowledge on SFN is not very widespread, although it's probably very common. You should also take into account that if doctors do not see an indication for skin biopsy, then you won't get it or you have to pay for it yourself and that's likely the case, when people tell the doctor, that their symptoms were caused by SSRIs.
I have a very strong hunch that many people here have other SFN symptoms that they don't focus on because the sexual ones seem most devastating. Dry skin? Inability to sweat from arms or legs? Tingling, itchiness, prickling? Numbness in other parts of the body? Burning or chills? Any of these can easily serve as an indication to get the biopsy.
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Re: PSSD could be small fiber polyneuropathy
As I said, although I'm not fully convinced by your idea, I see value in looking into this.I have a very strong hunch that many people here have other SFN symptoms that they don't focus on because the sexual ones seem most devastating. Dry skin? Inability to sweat from arms or legs? Tingling, itchiness, prickling? Numbness in other parts of the body? Burning or chills? Any of these can easily serve as an indication to get the biopsy.
Perhaps this could also be connected to the hypothesis that PSSD might be caused by Small Intestinal Bacterial Overgrowth, if the latter can also cause SFN (did not look into this, so maybe this is bullshit).
Re: PSSD could be small fiber polyneuropathy
electroneuromyography can detect fiber polyneuropathy? Or only double biopsy?
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Re: It is 100% small fiber polyneuropathy
Love your work. I’ve been a huge proponent of the autoimmune theory for a long time. Unfortunately, on other forums, it’s weirdly put down aggressively even when members support it. Weird.
Anyway, I think that there could potentially still be an autoimmune reaction occurring. Some people have had great results with immunosuppressants and when they’re sick. Possibly the autoimmune reaction is ongoing and causing our symptoms. This theory has been presented for years across all forums. I’m lucky that I’ve visited top immunologists and have been to top hospitals and the general consensus is that it’s an immune related event / autoimmunity. Makes sense with the crashes. Makes sense that some people crash two weeks off the drug. Makes sense where people get windows. Anyway would love to continue this convo and curious on your thoughts / doctors thoughts.
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