My PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

This is for hypothesis and even educated speculation.
cdraham
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My PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

Unread post by cdraham »

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Last edited by cdraham on Fri Nov 05, 2021 3:41 pm, edited 22 times in total.
bigpoppa10040
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Re: A more general PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

Unread post by bigpoppa10040 »

Love this theory. My theory is more along autoimmune. I think the high ammonia is from muscle breakdown and thus protein breakdown. But yes these are the theories I agree with
cdraham
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Re: A more general PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

Unread post by cdraham »

bigpoppa10040 wrote: Fri Oct 29, 2021 8:56 pm Love this theory. My theory is more along autoimmune. I think the high ammonia is from muscle breakdown and thus protein breakdown. But yes these are the theories I agree with
I agree with autoimmunity. Behind autoimmunity are often infections - but mainstream medicine/rheumatologists don't quite agree with that. Testing ANA titers should provide more insights..
bigpoppa10040
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Re: My PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

Unread post by bigpoppa10040 »

Agreed. I can tell you ANA titers have not consistently come back high across all forums. I can tell you from talking to 30 doctors lol that autoimmunity is in its infancy and often the exact right thing needs to be tested for to find antibodies..like a needle in a haystack. The infection etiology triggering autoimmunity is a big one for me
PIEDOderPSSD
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Re: My PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

Unread post by PIEDOderPSSD »

My pssd symptoms don't have loss of anxiety, it's still there, social anxiety and on the edge of a panic attack often when talking to a girl or be center of attention. It's the reason i took ssri, this issue showed up out of no where and was getting worse, hence why i took an snri(venlafaxine). I took it 2 weeks then off. Another month later, i took it for two weeks then off again. 2 weeks after quitting, i lost attraction and motivation to talk with my girlfriend. 2 months after, i had inconsistent symptoms of ed without porn and watery ejaculation. Then these sorted themselves out. 4 months later, i got ed. In my case, pssd kept on getting worse. In 5 months after my last dose, i was completely impotent. Until that moment i had no idea what happened to me. After learning about pssd, everything clicked. All my positive emotions have been reduced to 5~10%, but my negative emotions still exist like anger, frustration, hopelessness... I could no longer feel excited, happy, no motivation to contact friends and family, realized i no longer day dream, not following hobbies anymore... in the 7th month i got tinnitus and my symptoms stabilized or at least it seemed to be.
The 8th month i had the first window, i felt hypersexuality like i have never been in my whole life, it was so intense.

It's been two years now, last few months, i am getting more and more subtle windows, but more intense waves in return. This whole thing is a rollercoaster. I am also able to feel positive emotions again, but only for brief moments and usually happens in the middle of the day.

My baseline now is slowly getting better, but i still consider myself not functional but the good thing, i am not completely impotent.


My main question here is, why are my symptoms the worst in the evening/night. For example, i would have some sort of sexual function in the morning or in the afternoon but at night, it's really really bad and could no longer get the slightest erection or it would be really soft and not usable. I notice my symptoms are often the best and feel more functional during the early afternoon.
Also during windows( my windows are usually no longer than 4 days) i completely crash each evening and when it's around 9pm, i feel completely numb and impotent. Next morning, i would be normal again and this cycle repeats until my window switches off(also at night and doesn't come back next morning).

And during my baseline days, it's also the same cycle. I actually have a Baseline of maybe 30% which is somewhat acceptable for me and i would have moved on with my life,these night crashes drive me insane.

I found cinnamon could give me windows.
Cialis as well.
All these windows are usually from 1 to 3 days. And always still completely crash at night. Very rarely this doesn't happen during the best windows which involve gential sensitivity reversal and pleasure feeling of arousal flowing through all my body. (I had this twice now during my 2 years of pssd).
PsychoGenesis
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Re: My PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

Unread post by PsychoGenesis »

hey cdraham nice list and summary :)
yes for ammonia being responsible for headaches at least, tested with SB/glycine here, may take a few intermittent doses to notice

my ANA was negative fyi
cdraham
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Re: My PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

Unread post by cdraham »

PsychoGenesis wrote: Sat Oct 30, 2021 5:48 am hey cdraham nice list and summary :)
yes for ammonia being responsible for headaches at least, tested with SB/glycine here, may take a few intermittent doses to notice

my ANA was negative fyi
That's interesting, what was the dose? Maybe genes for weak ammonia removal are another predisposing factor for pssd. Many people get SIBO without the obvious sexual sides - I think the ones that do have issues with the genes that control ammonia removal
nicopickle
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Re: My PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

Unread post by nicopickle »

your post is very interesting to me. after doing a single FMT i was able to sleep fine for the first time in ages. i haven’t done any fmts since but i believe that it takes several to get good effects
cdraham
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Re: My PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

Unread post by cdraham »

nicopickle wrote: Sat Oct 30, 2021 7:43 am your post is very interesting to me. after doing a single FMT i was able to sleep fine for the first time in ages. i haven’t done any fmts since but i believe that it takes several to get good effects
What do you mean by sleep fine. How is your sleep usually, what improved?
nicopickle
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Re: My PSSD hypothesis (NH3, hyperammonemia, infections) 3 years of research, trial and error

Unread post by nicopickle »

after doing the fmt within an hour. i had to have a nap. i have sleep trouble most of the time. however that night after the fmt i slept very well
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