Noted from this PSSD study "MP78-15 POST-SSRI SEXUAL DYSFUNCTION (PSSD): TEN YEAR RETROSPECTIVE CHART REVIEW"
" erectile tissue inhomogeneity is common,
consistent with erectile tissue fibrosis/decreased erectile tissue
expandability as an underlying vascular ED pathophysiology, and
decreased genital sensation from neurological dysfunction "
This man with PFS found a test that revealed the presence of fibrosis: Penile Elastography.
https://forum.propeciahelp.com/t/penile ... aphy/47827
" After several years of going through all kind of medical tests, I found the test I needed. It’s called penile elastography.
I had the typical PFS (depression, anxiety, erectile dysfunction). The doppler ultrasound showed a venous leak. So there was clearly a problem, but nobody was able to detect the physical cause, since the penile MRI was apparently normal.
A couple of months ago, an urologist suggested that I go through a penile elastography test, which is non invasive and is used to detect possible fibrosis in the flaccid penis.
Finally I found the cause of my physical problems: there is fibrosis in the septum of the penis, usually undetectable on palpation and even in doppler ultrasound/MRI (because these tests measure everything in erection, so the tissues are stretched).
So the hypothesis is this:
Finasteride may have weakened the penile tissues
Small trauma (masturbation, sex) may have injured the tissues and produced fibrosis in places that are not easy to detect
Blood flow in the penis gets impaired
All this is apart from the potential neurological effects.
So if you are facing physical issues (erectile dysfunction, hourglass effect in pre-erect state, etc.), don’t waste time and go for a penile elastography test.
Please share your results. I am pretty sure that most of us have this problem. "
I'm trying to figure out if this exam is also done on female genitalia.
Genital Fibrosis and Elastography
Re: Genital Fibrosis and Elastography
I add this: an acquaintance of mine who for some time believed he had PSSD although following Risperdal, has done many examinations over the years and he too was eventually found to have fibrosis in the corpora cavernosa. He is very angry with doctors because now he believes that if only he had intervened from the beginning with taking Cialis daily for 6 months and with shockwave therapy he could have avoided the chronicity of fibrosis. I don't know how true this is.
Re: Genital Fibrosis and Elastography
It's known from early times finasteride makes changes in transforming growth factor beta, a signaling protein involved in elastin control.
https://pubmed.ncbi.nlm.nih.gov/23587732/
https://pubmed.ncbi.nlm.nih.gov/31000815/
https://pubmed.ncbi.nlm.nih.gov/30267556/
https://pubmed.ncbi.nlm.nih.gov/19473283/
https://pubmed.ncbi.nlm.nih.gov/9817381/
https://pubmed.ncbi.nlm.nih.gov/22068323/
https://pubmed.ncbi.nlm.nih.gov/11554221/
https://pubmed.ncbi.nlm.nih.gov/24311892/
https://pubmed.ncbi.nlm.nih.gov/20519274/
https://pubmed.ncbi.nlm.nih.gov/9759702/
https://pubmed.ncbi.nlm.nih.gov/29949176/
https://pubmed.ncbi.nlm.nih.gov/23587732/
https://pubmed.ncbi.nlm.nih.gov/31000815/
https://pubmed.ncbi.nlm.nih.gov/30267556/
https://pubmed.ncbi.nlm.nih.gov/19473283/
https://pubmed.ncbi.nlm.nih.gov/9817381/
https://pubmed.ncbi.nlm.nih.gov/22068323/
https://pubmed.ncbi.nlm.nih.gov/11554221/
https://pubmed.ncbi.nlm.nih.gov/24311892/
https://pubmed.ncbi.nlm.nih.gov/20519274/
https://pubmed.ncbi.nlm.nih.gov/9759702/
https://pubmed.ncbi.nlm.nih.gov/29949176/
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Re: Genital Fibrosis and Elastography
i'd research colchicine, it's a cheap off label drug for covid that also happens to treat peyrone disease
Re: Genital Fibrosis and Elastography
I'd research collagenases as well (I actually will). They are very interesting and also treat peyronie disease.PsychoGenesis wrote: ↑Sat Feb 27, 2021 9:48 am i'd research colchicine, it's a cheap off label drug for covid that also happens to treat peyrone disease
My blog "The Research Zone" is currently down.
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Re: Genital Fibrosis and Elastography
I can not find if there is elastography at the level of vulva / clitoris
Re: Genital Fibrosis and Elastography
So if you are facing physical issues (erectile dysfunction, hourglass effect in pre-erect state, etc.),
Pelvic floor dysfunction will cause exact symptoms
Pelvic floor dysfunction will cause exact symptoms
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