I have reason to believe acetylcholine receptors are desensitized in PSSD. I believe choline uptake in general is awry in the condition as well.
Curious to hear others' thoughts.
THX
Choline pathways
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Re: Choline pathways
Could you please elaborate a little bit?rmichaelballow wrote: ↑Thu Feb 11, 2021 12:06 am I have reason to believe acetylcholine receptors are desensitized in PSSD. I believe choline uptake in general is awry in the condition as well.
And if your theory was true, what could improve symptoms?
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, 5mg/day, Feb-May 2020.
Symptoms: sexual & emotional numbness
Symptoms: sexual & emotional numbness
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Re: Choline pathways
I just wanted to start the conversation on the topic. Up-regulating receptors (as they come and go, build and degrade fluxingly) is a tough one to crack. However, I've had success with low dose Citicoline (20-70MG), combined with an uptake agent (Coluracetam - high affinity choline uptake), with guys WHERE targeting serotonin binding, test, and DA release has only gone so far.... particularly on the EQ and sensitivity side of things.
ACH concentrations - ACH uptake - DA release
Still way early for me to be conclusive about it, but there is early success.
ACH concentrations - ACH uptake - DA release
Still way early for me to be conclusive about it, but there is early success.
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