PSSD and thyroid

This is for hypothesis and even educated speculation.
malink
Posts: 10
Joined: Wed Sep 30, 2020 9:35 am
Contact:

PSSD and thyroid

Unread post by malink »

Hi, I would like to bring to everyone the connection between PSSD and thyroid. In here many, like myself, have had signs of hypothyroidism at the end of SSRI treatment, with slow metabolism, low temperatures and many other symptoms. I emphasize that the thyroid is responsible for many bodily functions, and a thyroid malfunction can compromise everything, including libido and erection.

I quote some articles:

https://www.physiciansweekly.com/the-im ... -analysis/

Here SSRIs are said to reduce thyroid function.
Like this there are tons of other articles on the web with thyroid and PSSD connection.

Read here, this step is also very important !!

https://www.nature.com/articles/4000963
https://pubmed.ncbi.nlm.nih.gov/11077070/

It seems clear that the thyroid and serotonin receptors are connected. The problem is that supplementing with the thyroid hormones T3 and T4 does not solve our condition. Myself with hashimoto hypothyroidism, I supplemented with hormones to lower TSH, but the symptoms did not go away!

Who knows more about thyroid function and what the connection with PSSD might be, please come forward, thank you!
malink
Posts: 10
Joined: Wed Sep 30, 2020 9:35 am
Contact:

Re: PSSD and thyroid

Unread post by malink »

Nobody?
User avatar
kpavel
Posts: 234
Joined: Thu Aug 15, 2019 7:50 am
Contact:

Re: PSSD and thyroid

Unread post by kpavel »

Perhaps there are some studies, and you show studies around 5-ht1/2 receptors. And thyroid gland most likely plays a significant positive role in sexual health. But what if autoimmunity is a more characteristic issue for pssd? Or what about vitamin D and Hashimoto's? https://pubmed.ncbi.nlm.nih.gov/28073128/

Or pulmonary hypertension was a big topic in 90s discussing its cause by a serotonergic mechanism (appetite suppressing fenfluramine causes PH).
https://pubmed.ncbi.nlm.nih.gov/23474667/ They call the connection of PH with Hashimoto's an 'immunogenetic overlap'.

On my current topic of interest: https://pubmed.ncbi.nlm.nih.gov/19321193/ Is there someone with pssd and with Grave's disease guys?
https://pubmed.ncbi.nlm.nih.gov/7628400/
Or an autoimmune response in the brain of the same nature https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924386/
User avatar
Meso
Posts: 884
Joined: Tue Jan 22, 2019 3:00 pm
Contact:

Re: PSSD and thyroid

Unread post by Meso »

I'm trying low dose Levothyroxine albeit for intense post-covid fatigue, not for PSSD.

It provides some energy and a libido boost. It also increased penile sensitivity which is not something that I like. I find that it only works when combined with Rasagiline though; it has no effects when it's taken alone.

If T4/T3 don't work for you, what about desiccated thyroid? Have you tested your rT3?

For what it's worth, I notice that my resting body temperature is lower after PSSD. It was 36 degrees C before my recent trial of Levothyroxine where it went up to 37 degress. Some people note that subclinical hypothyroidism is better detected through low resting body temperature.
Blog: Link 1
Q&A session 1: HTML
malink
Posts: 10
Joined: Wed Sep 30, 2020 9:35 am
Contact:

Re: PSSD and thyroid

Unread post by malink »

Meso wrote: Wed Jan 13, 2021 1:42 pm I'm trying low dose Levothyroxine albeit for intense post-covid fatigue, not for PSSD.

It provides some energy and a libido boost. It also increased penile sensitivity which is not something that I like. I find that it only works when combined with Rasagiline though; it has no effects when it's taken alone.

If T4/T3 don't work for you, what about desiccated thyroid? Have you tested your rT3?

For what it's worth, I notice that my resting body temperature is lower after PSSD. It was 36 degrees C before my recent trial of Levothyroxine where it went up to 37 degress. Some people note that subclinical hypothyroidism is better detected through low resting body temperature.
I tried bovine dried thyroid from New Zealand, but nothing. The Tsh was very high (20!) But it returned in the range with T3 and T4, but I maintain all the symptoms of hypothyroidism, in addition to those of PSSD. Incidentally, there are theories that T3 desensitises the 5HT1A receptor even more, so it seems that I need treatment for my thyroid, but this could make PSSD worse! How do you explain this, meso? As for PSSD, my only symptom is erectile dysfunction, which is not cured with either cialis or viagra. For the rest, the orgasm remained unchanged in the pre-PSSD and I have no other symptoms!
User avatar
Meso
Posts: 884
Joined: Tue Jan 22, 2019 3:00 pm
Contact:

Re: PSSD and thyroid

Unread post by Meso »

malink wrote: Thu Jan 14, 2021 5:20 am I tried bovine dried thyroid from New Zealand, but nothing. The Tsh was very high (20!) But it returned in the range with T3 and T4, but I maintain all the symptoms of hypothyroidism, in addition to those of PSSD. Incidentally, there are theories that T3 desensitises the 5HT1A receptor even more, so it seems that I need treatment for my thyroid, but this could make PSSD worse! How do you explain this, meso? As for PSSD, my only symptom is erectile dysfunction, which is not cured with either cialis or viagra. For the rest, the orgasm remained unchanged in the pre-PSSD and I have no other symptoms!
Erectile dysfunction could be a symptom of hypothyroidism according to research papers I read. It gets better as you control your thyroid hormones status.

About the 5HT1A desensitization, I doubt that it's significant. Thyroid hormones are generally pro-sexual, giving better libido, erectile function, orgasms, and even penile sensitivity. So, I doubt that 5HT1A desensitization is significant - and even if it was, thyroid hormones remain to be highly pro-sexual to care about this.

Try microdoses of Selegiline or Rasagiline with your thyroid hormones. Maybe you are like me and would feel it better with a dopaminergic. Who knows.
Blog: Link 1
Q&A session 1: HTML
malink
Posts: 10
Joined: Wed Sep 30, 2020 9:35 am
Contact:

Re: PSSD and thyroid

Unread post by malink »

Meso wrote: Thu Jan 14, 2021 6:20 am
malink wrote: Thu Jan 14, 2021 5:20 am I tried bovine dried thyroid from New Zealand, but nothing. The Tsh was very high (20!) But it returned in the range with T3 and T4, but I maintain all the symptoms of hypothyroidism, in addition to those of PSSD. Incidentally, there are theories that T3 desensitises the 5HT1A receptor even more, so it seems that I need treatment for my thyroid, but this could make PSSD worse! How do you explain this, meso? As for PSSD, my only symptom is erectile dysfunction, which is not cured with either cialis or viagra. For the rest, the orgasm remained unchanged in the pre-PSSD and I have no other symptoms!
Erectile dysfunction could be a symptom of hypothyroidism according to research papers I read. It gets better as you control your thyroid hormones status.

About the 5HT1A desensitization, I doubt that it's significant. Thyroid hormones are generally pro-sexual, giving better libido, erectile function, orgasms, and even penile sensitivity. So, I doubt that 5HT1A desensitization is significant - and even if it was, thyroid hormones remain to be highly pro-sexual to care about this.

Try microdoses of Selegiline or Rasagiline with your thyroid hormones. Maybe you are like me and would feel it better with a dopaminergic. Who knows.
https://www.nature.com/articles/4000963

This I meant! However, I also increased the dosages of T3 and T4, but nothing. I have taken many dopamine agonists over the years, but they haven't helped. What is strange is that by increasing the dosages of thyroid hormones, I still cannot raise my temperature and speed up my metabolism! Mine is hashimoto hypothyroidism, my antibodies are skyrocketing and attacking my thyroid, which is not working. I also take selenium just to lower antibodies. In any case it was the SSRIs that put me in this condition of hypothyroidism and I can't get out of it, despite the thyroid hormones! The key is always the 5HT1A receptor, even for the thyroid, as we read from that article. Advice? Thanks a lot!
User avatar
Meso
Posts: 884
Joined: Tue Jan 22, 2019 3:00 pm
Contact:

Re: PSSD and thyroid

Unread post by Meso »

malink wrote: Thu Jan 14, 2021 6:37 am I have taken many dopamine agonists over the years, but they haven't helped. What is strange is that by increasing the dosages of thyroid hormones, I still cannot raise my temperature and speed up my metabolism! Mine is hashimoto hypothyroidism, my antibodies are skyrocketing and attacking my thyroid, which is not working. I also take selenium just to lower antibodies. In any case it was the SSRIs that put me in this condition of hypothyroidism and I can't get out of it, despite the thyroid hormones! The key is always the 5HT1A receptor, even for the thyroid, as we read from that article. Advice? Thanks a lot!
Have you tried combining a MAO-B inhibitor (not a dopamine agonist) PLUS levothyroxine? I wasn't feeling the levothyroxine up until I combined it with low dose Rasagiline or Selegiline. Now it's increasing my body temperature and I'm feeling it. D1 and D5 receptors are important for thyroid hormones' effects in stimulating cAMP.

That aside, some other guy started feeling his thyroid hormones when he combined them with Metformin. It's not surprising given AMPK activation effect on the mitochondria.
Blog: Link 1
Q&A session 1: HTML
malink
Posts: 10
Joined: Wed Sep 30, 2020 9:35 am
Contact:

Re: PSSD and thyroid

Unread post by malink »

Meso wrote: Thu Jan 14, 2021 2:15 pm
malink wrote: Thu Jan 14, 2021 6:37 am I have taken many dopamine agonists over the years, but they haven't helped. What is strange is that by increasing the dosages of thyroid hormones, I still cannot raise my temperature and speed up my metabolism! Mine is hashimoto hypothyroidism, my antibodies are skyrocketing and attacking my thyroid, which is not working. I also take selenium just to lower antibodies. In any case it was the SSRIs that put me in this condition of hypothyroidism and I can't get out of it, despite the thyroid hormones! The key is always the 5HT1A receptor, even for the thyroid, as we read from that article. Advice? Thanks a lot!
Have you tried combining a MAO-B inhibitor (not a dopamine agonist) PLUS levothyroxine? I wasn't feeling the levothyroxine up until I combined it with low dose Rasagiline or Selegiline. Now it's increasing my body temperature and I'm feeling it. D1 and D5 receptors are important for thyroid hormones' effects in stimulating cAMP.

That aside, some other guy started feeling his thyroid hormones when he combined them with Metformin. It's not surprising given AMPK activation effect on the mitochondria.
I've never combined them! Why do you think e would be combined with a MAO-B inhibitor?
Post Reply

Who is online

Users browsing this forum: No registered users and 2 guests